ENSG00000151148

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000342494 ENSG00000151148 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE3B protein_coding protein_coding 20.96658 21.25689 18.5733 3.516725 1.286702 -0.1946019 7.5532704 7.353385 6.2993474 1.20741632 0.22096545 -0.2228783 0.35984167 0.34600000 0.34440000 -0.00160000 1.000000e+00 1.650292e-25 FALSE TRUE
ENST00000434735 ENSG00000151148 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE3B protein_coding protein_coding 20.96658 21.25689 18.5733 3.516725 1.286702 -0.1946019 1.0699104 1.665483 1.1418089 0.48375153 0.13312809 -0.5406755 0.05104167 0.08326667 0.06256667 -0.02070000 8.821077e-01 1.650292e-25 FALSE TRUE
ENST00000536398 ENSG00000151148 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE3B protein_coding protein_coding 20.96658 21.25689 18.5733 3.516725 1.286702 -0.1946019 1.2634140 2.169474 0.9845543 1.08711091 0.34287098 -1.1318578 0.06038750 0.09593333 0.05606667 -0.03986667 9.958523e-01 1.650292e-25 FALSE TRUE
ENST00000537063 ENSG00000151148 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE3B protein_coding protein_coding 20.96658 21.25689 18.5733 3.516725 1.286702 -0.1946019 0.9460963 1.786517 0.3546523 0.31254206 0.04822696 -2.3006094 0.04527917 0.08566667 0.01896667 -0.06670000 1.430850e-05 1.650292e-25 FALSE TRUE
ENST00000539599 ENSG00000151148 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE3B protein_coding protein_coding 20.96658 21.25689 18.5733 3.516725 1.286702 -0.1946019 1.0555129 0.000000 2.1482055 0.00000000 0.26725686 7.7536884 0.05300833 0.00000000 0.11560000 0.11560000 1.650292e-25 1.650292e-25 FALSE TRUE
ENST00000539843 ENSG00000151148 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE3B protein_coding retained_intron 20.96658 21.25689 18.5733 3.516725 1.286702 -0.1946019 2.8273938 2.276983 2.7518158 2.27698305 1.38855606 0.2721714 0.13099167 0.08096667 0.13850000 0.05753333 5.220046e-01 1.650292e-25 TRUE FALSE
ENST00000605142 ENSG00000151148 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE3B protein_coding protein_coding 20.96658 21.25689 18.5733 3.516725 1.286702 -0.1946019 1.6518133 1.286475 1.3841409 0.03517015 0.15208720 0.1047819 0.07836250 0.06336667 0.07423333 0.01086667 7.184214e-01 1.650292e-25 FALSE TRUE
MSTRG.7983.2 ENSG00000151148 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE3B protein_coding   20.96658 21.25689 18.5733 3.516725 1.286702 -0.1946019 1.6265838 1.139516 2.1051020 0.48095207 0.29152553 0.8797008 0.08036250 0.06343333 0.11496667 0.05153333 5.242201e-01 1.650292e-25 FALSE TRUE
MSTRG.7983.6 ENSG00000151148 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE3B protein_coding   20.96658 21.25689 18.5733 3.516725 1.286702 -0.1946019 1.5273874 2.308714 0.4124148 0.05591958 0.41241483 -2.4565925 0.07120000 0.11383333 0.02056667 -0.09326667 9.540860e-02 1.650292e-25 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151148 E001 9.0544830 0.0304214971 7.167736e-01 8.123343e-01 12 109477402 109477627 226 + 0.927 1.018 0.336
ENSG00000151148 E002 3.5292481 0.1205971906 2.385005e-01 3.724023e-01 12 109477628 109477633 6 + 0.443 0.728 1.295
ENSG00000151148 E003 3.3840754 0.1088052358 1.388373e-01 2.464956e-01 12 109477634 109477634 1 + 0.384 0.727 1.612
ENSG00000151148 E004 3.8290567 0.0719860944 2.427706e-01 3.774381e-01 12 109477635 109477637 3 + 0.495 0.747 1.107
ENSG00000151148 E005 20.6694398 0.0011363495 8.849271e-02 1.728193e-01 12 109477638 109477651 14 + 1.375 1.290 -0.296
ENSG00000151148 E006 24.4460092 0.0067357217 3.765948e-01 5.209225e-01 12 109477652 109477652 1 + 1.412 1.386 -0.090
ENSG00000151148 E007 31.0601198 0.0053907623 8.368725e-01 8.979909e-01 12 109477653 109477654 2 + 1.463 1.522 0.203
ENSG00000151148 E008 69.9807975 0.0125125570 4.864034e-01 6.241557e-01 12 109477655 109477764 110 + 1.789 1.880 0.305
ENSG00000151148 E009 19.1712454 0.0142122247 5.927397e-01 7.152370e-01 12 109477765 109477776 12 + 1.238 1.330 0.323
ENSG00000151148 E010 89.1220705 0.0003221646 5.183187e-02 1.124221e-01 12 109477777 109478109 333 + 1.876 1.996 0.404
ENSG00000151148 E011 113.7427346 0.0012471631 6.325044e-01 7.473388e-01 12 109481637 109481742 106 + 2.017 2.081 0.215
ENSG00000151148 E012 179.1687538 0.0066314037 9.011454e-01 9.409500e-01 12 109483531 109483712 182 + 2.224 2.268 0.149
ENSG00000151148 E013 144.8640207 0.0100033936 3.781727e-01 5.224691e-01 12 109483861 109483981 121 + 2.096 2.199 0.343
ENSG00000151148 E014 0.0000000       12 109483982 109484021 40 +      
ENSG00000151148 E015 101.4689628 0.0090066618 3.908697e-01 5.348203e-01 12 109486012 109486071 60 + 1.946 2.044 0.329
ENSG00000151148 E016 130.3066875 0.0087730902 2.030013e-01 3.299812e-01 12 109486471 109486575 105 + 2.040 2.160 0.403
ENSG00000151148 E017 152.6225895 0.0178835998 6.092858e-01 7.288103e-01 12 109488572 109488668 97 + 2.124 2.218 0.312
ENSG00000151148 E018 135.8284015 0.0177477494 6.623360e-01 7.706615e-01 12 109489919 109490004 86 + 2.079 2.164 0.283
ENSG00000151148 E019 84.8538440 0.0181436645 1.786358e-13 4.903218e-12 12 109490005 109490489 485 + 1.435 2.099 2.247
ENSG00000151148 E020 46.8955072 0.0244657017 3.267985e-07 3.000436e-06 12 109490490 109491044 555 + 1.273 1.831 1.911
ENSG00000151148 E021 61.3712388 0.0115582573 4.645554e-02 1.028583e-01 12 109491045 109491127 83 + 1.838 1.754 -0.283
ENSG00000151148 E022 1.9163721 0.1299680268 3.331240e-02 7.841229e-02 12 109491128 109492737 1610 + 0.132 0.621 3.163
ENSG00000151148 E023 82.0528173 0.0003984053 3.895940e-07 3.519667e-06 12 109497818 109497923 106 + 1.995 1.843 -0.513
ENSG00000151148 E024 95.0389367 0.0002870802 8.332798e-10 1.253274e-08 12 109498233 109498353 121 + 2.071 1.895 -0.590
ENSG00000151148 E025 96.8828417 0.0003739625 1.300484e-07 1.292389e-06 12 109499633 109499810 178 + 2.062 1.916 -0.488
ENSG00000151148 E026 51.3002965 0.0004622569 9.245119e-04 3.700841e-03 12 109501371 109501424 54 + 1.775 1.658 -0.397
ENSG00000151148 E027 72.6039386 0.0004043237 9.454713e-05 4.964707e-04 12 109501425 109501534 110 + 1.925 1.808 -0.393
ENSG00000151148 E028 99.8035391 0.0002916767 6.049041e-04 2.551477e-03 12 109503023 109503190 168 + 2.040 1.964 -0.255
ENSG00000151148 E029 106.5556638 0.0002956373 5.201391e-03 1.647861e-02 12 109507564 109507735 172 + 2.054 2.003 -0.171
ENSG00000151148 E030 16.1126262 0.0078380570 1.805679e-04 8.804481e-04 12 109508450 109509595 1146 + 1.375 1.071 -1.078
ENSG00000151148 E031 76.7315378 0.0003496808 4.376851e-04 1.919446e-03 12 109509596 109509714 119 + 1.937 1.841 -0.324
ENSG00000151148 E032 66.0389584 0.0035138968 1.763789e-03 6.484213e-03 12 109510344 109510458 115 + 1.882 1.765 -0.396
ENSG00000151148 E033 81.4931556 0.0003557952 7.455650e-09 9.407556e-08 12 109511204 109511303 100 + 2.005 1.824 -0.608
ENSG00000151148 E034 0.0000000       12 109511304 109511315 12 +      
ENSG00000151148 E035 94.3332532 0.0083208700 3.935580e-03 1.296082e-02 12 109516765 109516884 120 + 2.034 1.919 -0.387
ENSG00000151148 E036 1.9897302 0.0069079662 6.033075e-02 1.271709e-01 12 109517917 109518013 97 + 0.623 0.341 -1.421
ENSG00000151148 E037 0.8178402 0.0759846460 3.120577e-01 4.545855e-01 12 109519556 109521147 1592 + 0.132 0.339 1.738
ENSG00000151148 E038 131.2896352 0.0038545879 8.947349e-02 1.743285e-01 12 109521148 109521324 177 + 2.128 2.102 -0.088
ENSG00000151148 E039 96.9457756 0.0023506781 5.950645e-02 1.257762e-01 12 109521441 109521551 111 + 2.002 1.968 -0.114
ENSG00000151148 E040 95.7617842 0.0006266113 6.249995e-01 7.411988e-01 12 109523978 109524115 138 + 1.961 1.989 0.091
ENSG00000151148 E041 86.3508819 0.0022632915 5.008749e-02 1.093144e-01 12 109524438 109524503 66 + 1.955 1.913 -0.140
ENSG00000151148 E042 83.8711874 0.0059597474 5.027747e-02 1.096570e-01 12 109526358 109526416 59 + 1.953 1.892 -0.205
ENSG00000151148 E043 3.4602382 0.0829846860 9.318480e-01 9.610626e-01 12 109526417 109526433 17 + 0.622 0.638 0.067
ENSG00000151148 E044 48.3536358 0.0045671489 1.824646e-01 3.043116e-01 12 109529890 109529895 6 + 1.702 1.665 -0.124
ENSG00000151148 E045 66.3002404 0.0052917442 5.295965e-01 6.623610e-01 12 109529896 109529929 34 + 1.812 1.820 0.028
ENSG00000151148 E046 120.4229706 0.0091750830 9.278389e-01 9.585776e-01 12 109529930 109530072 143 + 2.052 2.090 0.127
ENSG00000151148 E047 107.2147384 0.0064431575 9.710559e-01 9.859138e-01 12 109530547 109530658 112 + 2.000 2.041 0.138
ENSG00000151148 E048 85.5694002 0.0038576727 3.277787e-01 4.712471e-01 12 109533466 109533558 93 + 1.872 1.963 0.307
ENSG00000151148 E049 19.7452941 0.0009571244 9.617437e-01 9.798884e-01 12 109533657 109533947 291 + 1.281 1.328 0.165
ENSG00000151148 E050 55.8505502 0.0178351545 5.531229e-01 6.823211e-01 12 109533948 109534590 643 + 1.693 1.780 0.297
ENSG00000151148 E051 767.6278912 0.0060092886 7.375022e-05 3.981352e-04 12 109534591 109536705 2115 + 2.764 2.943 0.597