ENSG00000151136

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000280758 ENSG00000151136 HEK293_OSMI2_2hA HEK293_TMG_2hB BTBD11 protein_coding protein_coding 3.762795 4.967995 3.004457 0.4807871 0.2356522 -0.7236665 1.3860064 0.98445703 1.5209069 0.10762901 0.09445138 0.62240565 0.40277917 0.20223333 0.5084 0.30616667 2.471473e-05 2.471473e-05 FALSE TRUE
ENST00000357167 ENSG00000151136 HEK293_OSMI2_2hA HEK293_TMG_2hB BTBD11 protein_coding protein_coding 3.762795 4.967995 3.004457 0.4807871 0.2356522 -0.7236665 0.5034302 0.81130360 0.7729052 0.02567415 0.22499586 -0.06907792 0.14043750 0.16653333 0.2696 0.10306667 6.480052e-01 2.471473e-05 FALSE TRUE
ENST00000420571 ENSG00000151136 HEK293_OSMI2_2hA HEK293_TMG_2hB BTBD11 protein_coding protein_coding 3.762795 4.967995 3.004457 0.4807871 0.2356522 -0.7236665 0.1296901 0.05729868 0.2075068 0.05729868 0.16448536 1.69241059 0.03857917 0.01266667 0.0758 0.06313333 6.399277e-01 2.471473e-05 FALSE TRUE
ENST00000494235 ENSG00000151136 HEK293_OSMI2_2hA HEK293_TMG_2hB BTBD11 protein_coding protein_coding 3.762795 4.967995 3.004457 0.4807871 0.2356522 -0.7236665 1.6615650 3.04236263 0.3299778 0.55790483 0.32997783 -3.16641380 0.39549583 0.60286667 0.0950 -0.50786667 4.203819e-02 2.471473e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151136 E001 1.3160029 0.5334456622 3.500700e-01 4.942483e-01 12 107318421 107318433 13 + 0.480 0.221 -1.608
ENSG00000151136 E002 18.5758569 0.0011516036 3.804819e-03 1.259495e-02 12 107318434 107318940 507 + 1.363 1.212 -0.527
ENSG00000151136 E003 26.1032236 0.0187911172 4.214349e-04 1.856475e-03 12 107318941 107319897 957 + 1.551 1.299 -0.872
ENSG00000151136 E004 13.2190152 0.0013214994 2.188346e-03 7.805980e-03 12 107319898 107320075 178 + 1.254 1.053 -0.720
ENSG00000151136 E005 0.0000000       12 107320588 107320635 48 +      
ENSG00000151136 E006 16.7529251 0.0018820776 2.142192e-03 7.666317e-03 12 107520487 107520636 150 + 1.343 1.168 -0.616
ENSG00000151136 E007 17.8439204 0.0022754102 3.342495e-03 1.126966e-02 12 107543935 107544139 205 + 1.356 1.195 -0.566
ENSG00000151136 E008 0.2214452 0.0377499565 6.075368e-01   12 107580650 107581007 358 + 0.000 0.118 8.824
ENSG00000151136 E009 10.3645009 0.0284835287 1.143707e-01 2.119184e-01 12 107581152 107581304 153 + 1.110 0.980 -0.474
ENSG00000151136 E010 21.8605743 0.0032535195 1.538028e-03 5.759875e-03 12 107610190 107610355 166 + 1.439 1.274 -0.572
ENSG00000151136 E011 0.0000000       12 107610356 107610356 1 +      
ENSG00000151136 E012 19.7394302 0.0010349516 1.495537e-03 5.621304e-03 12 107612780 107612869 90 + 1.399 1.236 -0.570
ENSG00000151136 E013 16.7698991 0.0037482969 4.193008e-02 9.459989e-02 12 107615061 107615162 102 + 1.301 1.203 -0.343
ENSG00000151136 E014 15.5404601 0.0014152365 1.140132e-01 2.113719e-01 12 107617089 107617182 94 + 1.246 1.186 -0.211
ENSG00000151136 E015 19.6083039 0.0010548558 4.703732e-01 6.095922e-01 12 107617301 107617436 136 + 1.301 1.322 0.072
ENSG00000151136 E016 23.4501878 0.0341111668 5.564692e-01 6.851108e-01 12 107618158 107618378 221 + 1.387 1.388 0.006
ENSG00000151136 E017 27.5446327 0.0007320009 4.983047e-02 1.088575e-01 12 107619986 107620164 179 + 1.480 1.430 -0.172
ENSG00000151136 E018 0.1515154 0.0417368272 3.856766e-01   12 107634832 107634958 127 + 0.127 0.000 -9.739
ENSG00000151136 E019 23.1192115 0.0010106274 5.200429e-01 6.540741e-01 12 107635285 107635390 106 + 1.363 1.393 0.105
ENSG00000151136 E020 21.1847365 0.0013904124 9.748215e-01 9.883228e-01 12 107640311 107640413 103 + 1.294 1.371 0.269
ENSG00000151136 E021 20.1447080 0.0031812568 5.288777e-01 6.617504e-01 12 107642090 107642171 82 + 1.246 1.371 0.435
ENSG00000151136 E022 19.4771105 0.0010530901 6.044083e-01 7.249799e-01 12 107649206 107649274 69 + 1.238 1.353 0.403
ENSG00000151136 E023 0.9921577 0.0126468292 6.194112e-01 7.368340e-01 12 107649275 107650788 1514 + 0.225 0.352 0.879
ENSG00000151136 E024 0.0000000       12 107650789 107650897 109 +      
ENSG00000151136 E025 24.9522619 0.0028695400 9.479812e-01 9.713147e-01 12 107651674 107651787 114 + 1.369 1.440 0.244
ENSG00000151136 E026 263.8187461 0.0104618119 1.616343e-08 1.916816e-07 12 107657509 107659642 2134 + 2.241 2.520 0.932