ENSG00000151090

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356447 ENSG00000151090 HEK293_OSMI2_2hA HEK293_TMG_2hB THRB protein_coding protein_coding 2.32295 1.522864 4.94997 0.09948374 0.528097 1.694101 0.9790557 0.9840093 1.9704641 0.06203608 0.1074557 0.9945073 0.47474583 0.65550000 0.40373333 -0.251766667 6.455497e-02 1.563355e-05 FALSE TRUE
ENST00000396671 ENSG00000151090 HEK293_OSMI2_2hA HEK293_TMG_2hB THRB protein_coding protein_coding 2.32295 1.522864 4.94997 0.09948374 0.528097 1.694101 0.1453738 0.1508157 0.3035729 0.01755171 0.1140387 0.9633925 0.06788333 0.09846667 0.05856667 -0.039900000 5.236289e-01 1.563355e-05 FALSE TRUE
ENST00000428492 ENSG00000151090 HEK293_OSMI2_2hA HEK293_TMG_2hB THRB protein_coding protein_coding 2.32295 1.522864 4.94997 0.09948374 0.528097 1.694101 0.3232629 0.2154558 0.7526551 0.13145623 0.4048050 1.7581862 0.11576250 0.13386667 0.13923333 0.005366667 1.000000e+00 1.563355e-05   FALSE
ENST00000642307 ENSG00000151090 HEK293_OSMI2_2hA HEK293_TMG_2hB THRB protein_coding protein_coding 2.32295 1.522864 4.94997 0.09948374 0.528097 1.694101 0.3453501 0.0000000 1.1440282 0.00000000 0.2233979 6.8505347 0.10043750 0.00000000 0.24023333 0.240233333 1.563355e-05 1.563355e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151090 E001 3.7894242 0.0045532204 7.188757e-01 8.138646e-01 3 24117153 24118119 967 - 0.671 0.613 -0.250
ENSG00000151090 E002 0.7395785 0.2154389652 4.017407e-01 5.454443e-01 3 24118120 24118167 48 - 0.149 0.314 1.374
ENSG00000151090 E003 0.7353121 0.2264925448 4.081262e-01 5.517059e-01 3 24118168 24118213 46 - 0.149 0.315 1.379
ENSG00000151090 E004 63.4023252 0.0004739638 1.103312e-20 7.670430e-19 3 24118214 24119042 829 - 1.615 2.012 1.341
ENSG00000151090 E005 6.2926354 0.0026591866 2.288987e-06 1.757559e-05 3 24119043 24119055 13 - 0.564 1.143 2.277
ENSG00000151090 E006 5.5229671 0.0031287574 1.202732e-06 9.820447e-06 3 24119056 24119067 12 - 0.484 1.110 2.536
ENSG00000151090 E007 4.2382885 0.0042123516 2.187783e-05 1.343977e-04 3 24119068 24119070 3 - 0.422 1.012 2.503
ENSG00000151090 E008 4.6069827 0.0036750096 1.989233e-05 1.234535e-04 3 24119071 24119071 1 - 0.454 1.034 2.411
ENSG00000151090 E009 9.3968768 0.0018956109 6.909722e-09 8.775986e-08 3 24119072 24119168 97 - 0.690 1.304 2.296
ENSG00000151090 E010 186.7259007 0.0010890387 2.120554e-02 5.402393e-02 3 24119169 24122207 3039 - 2.265 2.202 -0.211
ENSG00000151090 E011 36.4859309 0.0040622178 5.732584e-03 1.790695e-02 3 24122208 24122764 557 - 1.599 1.403 -0.672
ENSG00000151090 E012 10.3508685 0.0162052478 6.939914e-01 7.949223e-01 3 24122765 24122837 73 - 1.018 1.071 0.194
ENSG00000151090 E013 15.0540659 0.0087189246 5.353034e-01 6.671717e-01 3 24122838 24122940 103 - 1.203 1.142 -0.216
ENSG00000151090 E014 25.4656521 0.0008021709 6.774687e-01 7.821827e-01 3 24122941 24123125 185 - 1.390 1.420 0.103
ENSG00000151090 E015 29.0480976 0.0008337510 3.716619e-01 5.161321e-01 3 24127499 24127757 259 - 1.432 1.491 0.204
ENSG00000151090 E016 21.4997075 0.0107584010 5.480551e-01 6.779671e-01 3 24133316 24133462 147 - 1.340 1.282 -0.204
ENSG00000151090 E017 27.1317228 0.0035587367 2.140987e-01 3.433601e-01 3 24143501 24143706 206 - 1.451 1.356 -0.330
ENSG00000151090 E018 0.5922303 0.0180753349 9.074740e-01 9.452653e-01 3 24143707 24144896 1190 - 0.208 0.181 -0.252
ENSG00000151090 E019 12.5166981 0.0042125902 4.148095e-02 9.377279e-02 3 24146675 24146717 43 - 1.168 0.942 -0.825
ENSG00000151090 E020 18.2190047 0.0099530627 7.715551e-03 2.306447e-02 3 24146718 24146822 105 - 1.332 1.053 -0.991
ENSG00000151090 E021 13.7778837 0.0030278238 6.570465e-02 1.362130e-01 3 24152390 24152407 18 - 1.203 1.012 -0.687
ENSG00000151090 E022 11.8559077 0.0098917300 4.184006e-02 9.443248e-02 3 24152408 24152409 2 - 1.156 0.914 -0.885
ENSG00000151090 E023 12.8555540 0.0044251505 8.728496e-02 1.710159e-01 3 24152410 24152430 21 - 1.174 0.990 -0.667
ENSG00000151090 E024 12.9175704 0.0025675768 1.357920e-01 2.422033e-01 3 24152431 24152462 32 - 1.168 1.013 -0.563
ENSG00000151090 E025 12.7953146 0.0059523354 6.134797e-02 1.289034e-01 3 24152463 24152490 28 - 1.174 0.967 -0.754
ENSG00000151090 E026 0.0000000       3 24165027 24165595 569 -      
ENSG00000151090 E027 17.0486491 0.0124259993 6.102731e-02 1.283649e-01 3 24190074 24190153 80 - 1.289 1.091 -0.703
ENSG00000151090 E028 11.4591230 0.0017471183 1.669292e-01 2.842091e-01 3 24190154 24190167 14 - 1.117 0.967 -0.549
ENSG00000151090 E029 25.4115601 0.0007955776 5.406809e-02 1.163704e-01 3 24190168 24190334 167 - 1.438 1.292 -0.507
ENSG00000151090 E030 11.2698998 0.0015514399 9.131267e-01 9.489411e-01 3 24228938 24228959 22 - 1.067 1.054 -0.044
ENSG00000151090 E031 13.7549624 0.0012894673 6.405791e-01 7.538048e-01 3 24228960 24229001 42 - 1.156 1.110 -0.164
ENSG00000151090 E032 0.3268771 0.0286044241 4.949997e-01   3 24237991 24238081 91 - 0.081 0.181 1.335
ENSG00000151090 E033 5.5608072 0.0029323488 3.242966e-02 7.668590e-02 3 24297226 24297323 98 - 0.878 0.554 -1.344
ENSG00000151090 E034 1.6671076 0.0100691952 1.185632e-01 2.178883e-01 3 24297324 24297371 48 - 0.484 0.181 -1.987
ENSG00000151090 E035 5.7215182 0.0590282266 7.822657e-01 8.602103e-01 3 24318358 24318494 137 - 0.827 0.752 -0.297
ENSG00000151090 E036 9.9645086 0.0017233934 3.339399e-01 4.776943e-01 3 24337300 24337371 72 - 1.051 0.942 -0.403
ENSG00000151090 E037 0.1472490 0.0454525714 1.000000e+00   3 24348558 24348614 57 - 0.081 0.000 -10.245
ENSG00000151090 E038 0.0000000       3 24348615 24348902 288 -      
ENSG00000151090 E039 0.0000000       3 24430101 24430172 72 -      
ENSG00000151090 E040 0.0000000       3 24483923 24484095 173 -      
ENSG00000151090 E041 0.0000000       3 24486400 24486595 196 -      
ENSG00000151090 E042 1.9769310 0.1248673960 8.611628e-01 9.144370e-01 3 24494652 24494686 35 - 0.453 0.484 0.154
ENSG00000151090 E043 6.7117403 0.0048217419 3.996976e-01 5.434338e-01 3 24494687 24494794 108 - 0.901 0.790 -0.432
ENSG00000151090 E044 1.8307261 0.0366737364 3.602574e-01 5.045778e-01 3 24494795 24495005 211 - 0.386 0.553 0.843
ENSG00000151090 E045 0.6955713 0.0167942628 3.644940e-01 5.088479e-01 3 24495133 24495441 309 - 0.149 0.309 1.337
ENSG00000151090 E046 0.1817044 0.0401281512 1.875409e-01   3 24495442 24495572 131 - 0.000 0.181 11.134
ENSG00000151090 E047 0.4031496 0.0270551100 4.706359e-02 1.039396e-01 3 24495574 24495756 183 - 0.000 0.309 12.167