ENSG00000151012

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000280612 ENSG00000151012 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC7A11 protein_coding protein_coding 3.081962 0.3898038 4.204866 0.03679467 0.2498633 3.398123 1.8837654 0.32690109 1.0114638 0.02842102 0.08550705 1.600241 0.71185000 0.8636667 0.24410000 -0.61956667 0.012812924 0.009697237 FALSE TRUE
MSTRG.25478.2 ENSG00000151012 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC7A11 protein_coding   3.081962 0.3898038 4.204866 0.03679467 0.2498633 3.398123 0.3903225 0.00000000 0.7358275 0.00000000 0.10583220 6.220770 0.08570417 0.0000000 0.17433333 0.17433333 0.009697237 0.009697237 FALSE TRUE
MSTRG.25478.4 ENSG00000151012 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC7A11 protein_coding   3.081962 0.3898038 4.204866 0.03679467 0.2498633 3.398123 0.1416433 0.00000000 0.4706456 0.00000000 0.27139502 5.586902 0.03537917 0.0000000 0.10496667 0.10496667 0.649704698 0.009697237 FALSE TRUE
MSTRG.25478.5 ENSG00000151012 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC7A11 protein_coding   3.081962 0.3898038 4.204866 0.03679467 0.2498633 3.398123 0.1851559 0.00000000 0.3582466 0.00000000 0.26656667 5.202600 0.03983750 0.0000000 0.08683333 0.08683333 0.750408919 0.009697237 FALSE TRUE
MSTRG.25478.6 ENSG00000151012 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC7A11 protein_coding   3.081962 0.3898038 4.204866 0.03679467 0.2498633 3.398123 0.1233601 0.00000000 0.7570872 0.00000000 0.43207273 6.261319 0.02865000 0.0000000 0.19370000 0.19370000 0.594431770 0.009697237 FALSE TRUE
MSTRG.25478.7 ENSG00000151012 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC7A11 protein_coding   3.081962 0.3898038 4.204866 0.03679467 0.2498633 3.398123 0.3100558 0.06290272 0.8715950 0.06290272 0.52028796 3.596071 0.08125833 0.1363333 0.19610000 0.05976667 0.816861781 0.009697237 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000151012 E001 126.0913040 0.0168106734 8.815476e-14 2.527721e-12 4 138164097 138171591 7495 - 1.862 2.296 1.457
ENSG00000151012 E002 6.4754007 0.0071438277 1.092982e-02 3.099270e-02 4 138171592 138171843 252 - 0.790 0.429 -1.618
ENSG00000151012 E003 7.2132311 0.0308051607 1.161367e-03 4.510217e-03 4 138171844 138172017 174 - 0.847 0.265 -2.846
ENSG00000151012 E004 10.5064420 0.0112270222 2.886157e-01 4.292198e-01 4 138179217 138179394 178 - 0.938 0.932 -0.024
ENSG00000151012 E005 10.8066054 0.0194091644 3.654064e-02 8.460559e-02 4 138180641 138180790 150 - 0.969 0.781 -0.723
ENSG00000151012 E006 7.4252757 0.0282960921 2.557856e-02 6.307476e-02 4 138182297 138182393 97 - 0.840 0.546 -1.234
ENSG00000151012 E007 6.0061553 0.0132935414 1.903143e-01 3.141681e-01 4 138183202 138183305 104 - 0.743 0.639 -0.433
ENSG00000151012 E008 6.0311343 0.0027993366 1.737537e-01 2.930656e-01 4 138185121 138185244 124 - 0.743 0.640 -0.431
ENSG00000151012 E009 1.2607212 0.2487522485 8.325310e-01 8.950594e-01 4 138194887 138194956 70 - 0.275 0.268 -0.046
ENSG00000151012 E010 2.0850084 0.0988918700 6.139911e-02 1.289880e-01 4 138194957 138195119 163 - 0.442 0.000 -11.442
ENSG00000151012 E011 0.4418608 0.0288602344 7.591160e-01 8.435350e-01 4 138198035 138198125 91 - 0.139 0.000 -9.227
ENSG00000151012 E012 1.0695787 0.0117397345 8.324766e-01 8.950229e-01 4 138198953 138199071 119 - 0.244 0.265 0.154
ENSG00000151012 E013 5.5937554 0.0031121541 2.609694e-02 6.414348e-02 4 138214585 138214629 45 - 0.733 0.428 -1.390
ENSG00000151012 E014 11.7678843 0.0014401921 6.455546e-02 1.343008e-01 4 138219266 138219365 100 - 0.992 0.888 -0.390
ENSG00000151012 E015 11.8991239 0.0015016380 3.641509e-01 5.085258e-01 4 138223199 138223324 126 - 0.981 1.011 0.111
ENSG00000151012 E016 16.0385609 0.0018856690 2.065074e-03 7.426583e-03 4 138232267 138232382 116 - 1.129 0.888 -0.890
ENSG00000151012 E017 16.3167265 0.0012031437 1.496773e-03 5.625393e-03 4 138236325 138236451 127 - 1.137 0.888 -0.919
ENSG00000151012 E018 31.4688101 0.0007289676 1.042360e-04 5.415830e-04 4 138241793 138242349 557 - 1.399 1.208 -0.668