ENSG00000150990

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308736 ENSG00000150990 HEK293_OSMI2_2hA HEK293_TMG_2hB DHX37 protein_coding protein_coding 52.50554 86.35531 32.39534 6.077852 0.6250351 -1.41422 40.90320 70.588290 23.479830 4.5132878 0.1768938 -1.5875970 0.75845833 0.8183000 0.72530000 -0.09300000 1.982351e-03 2.128891e-05 FALSE  
ENST00000543962 ENSG00000150990 HEK293_OSMI2_2hA HEK293_TMG_2hB DHX37 protein_coding retained_intron 52.50554 86.35531 32.39534 6.077852 0.6250351 -1.41422 2.54072 2.081416 3.678279 0.6791627 0.4607775 0.8184675 0.06073333 0.0236000 0.11350000 0.08990000 2.128891e-05 2.128891e-05 FALSE  
MSTRG.8287.4 ENSG00000150990 HEK293_OSMI2_2hA HEK293_TMG_2hB DHX37 protein_coding   52.50554 86.35531 32.39534 6.077852 0.6250351 -1.41422 4.91131 8.863922 2.056200 0.6534795 0.4615467 -2.1025919 0.08984583 0.1026333 0.06296667 -0.03966667 1.839463e-01 2.128891e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000150990 E001 6.2237936 2.240288e-02 6.947998e-01 7.955404e-01 12 124946825 124946825 1 - 0.710 0.782 0.291
ENSG00000150990 E002 18.1927279 5.375536e-02 6.287069e-01 7.441979e-01 12 124946826 124946830 5 - 1.126 1.207 0.288
ENSG00000150990 E003 123.5743313 5.885876e-03 9.293183e-06 6.222399e-05 12 124946831 124946932 102 - 1.774 2.043 0.907
ENSG00000150990 E004 1392.1799128 5.161795e-03 2.451019e-12 5.643391e-11 12 124946933 124947600 668 - 2.825 3.090 0.879
ENSG00000150990 E005 898.2685431 1.652213e-03 1.493382e-06 1.194851e-05 12 124947601 124947887 287 - 2.750 2.880 0.431
ENSG00000150990 E006 6.1424030 1.506013e-01 5.434012e-01 6.740286e-01 12 124947888 124948083 196 - 0.876 0.746 -0.510
ENSG00000150990 E007 597.5334271 3.679242e-04 2.627240e-09 3.604121e-08 12 124948084 124948181 98 - 2.570 2.702 0.440
ENSG00000150990 E008 12.1958176 1.440551e-03 7.594936e-01 8.438486e-01 12 124948182 124948615 434 - 0.994 1.036 0.157
ENSG00000150990 E009 534.9715214 1.597638e-04 2.243909e-09 3.115898e-08 12 124949986 124950059 74 - 2.522 2.652 0.434
ENSG00000150990 E010 557.5857041 9.950981e-04 1.805369e-07 1.745187e-06 12 124950149 124950243 95 - 2.533 2.672 0.465
ENSG00000150990 E011 646.8248447 2.654457e-04 3.534578e-03 1.182523e-02 12 124950413 124950550 138 - 2.659 2.723 0.214
ENSG00000150990 E012 14.1205244 5.363089e-03 8.677990e-02 1.702525e-01 12 124950551 124950689 139 - 1.213 1.044 -0.607
ENSG00000150990 E013 586.6913968 1.230635e-04 2.363042e-02 5.904861e-02 12 124950690 124950804 115 - 2.628 2.679 0.169
ENSG00000150990 E014 639.5600891 9.917215e-05 4.059246e-03 1.330816e-02 12 124952398 124952570 173 - 2.658 2.717 0.198
ENSG00000150990 E015 41.8322482 8.539275e-03 2.570888e-02 6.333760e-02 12 124952571 124953740 1170 - 1.650 1.495 -0.529
ENSG00000150990 E016 478.5640181 2.827883e-04 7.020969e-05 3.811182e-04 12 124953880 124953996 117 - 2.501 2.597 0.320
ENSG00000150990 E017 554.6860485 1.163221e-04 2.851779e-03 9.828645e-03 12 124954087 124954211 125 - 2.592 2.657 0.219
ENSG00000150990 E018 21.0108084 3.727783e-02 2.057412e-01 3.333452e-01 12 124956410 124956690 281 - 1.358 1.211 -0.514
ENSG00000150990 E019 734.0226691 3.581541e-04 3.345696e-01 4.783066e-01 12 124956691 124956879 189 - 2.771 2.764 -0.023
ENSG00000150990 E020 480.5632638 1.217917e-03 2.203214e-02 5.574372e-02 12 124957029 124957135 107 - 2.618 2.573 -0.152
ENSG00000150990 E021 479.3520525 1.621251e-04 9.077946e-08 9.286121e-07 12 124960312 124960423 112 - 2.654 2.559 -0.316
ENSG00000150990 E022 0.7761102 3.103973e-02 9.300947e-01 9.600025e-01 12 124964393 124964393 1 - 0.201 0.188 -0.126
ENSG00000150990 E023 690.3851363 3.890630e-04 1.993364e-07 1.910257e-06 12 124964394 124964626 233 - 2.805 2.722 -0.277
ENSG00000150990 E024 387.0339318 9.514727e-04 9.005148e-02 1.752150e-01 12 124964930 124965006 77 - 2.514 2.481 -0.110
ENSG00000150990 E025 488.1791136 1.507634e-04 1.661441e-03 6.158024e-03 12 124965668 124965812 145 - 2.629 2.577 -0.175
ENSG00000150990 E026 439.3381595 7.337236e-04 4.660428e-04 2.030272e-03 12 124966793 124966878 86 - 2.599 2.527 -0.238
ENSG00000150990 E027 13.1333481 1.645372e-03 7.875185e-10 1.191162e-08 12 124966879 124967005 127 - 1.431 0.863 -2.046
ENSG00000150990 E028 408.6353894 3.106256e-04 5.772213e-02 1.227236e-01 12 124967123 124967218 96 - 2.537 2.504 -0.110
ENSG00000150990 E029 489.5959895 2.374230e-03 4.695021e-02 1.037377e-01 12 124968534 124968648 115 - 2.630 2.583 -0.156
ENSG00000150990 E030 460.0499604 8.139845e-04 2.212935e-03 7.883300e-03 12 124968867 124968968 102 - 2.612 2.551 -0.204
ENSG00000150990 E031 468.0788511 2.137553e-03 4.301110e-04 1.890387e-03 12 124971302 124971415 114 - 2.642 2.553 -0.297
ENSG00000150990 E032 397.2541742 8.927836e-04 8.005748e-05 4.281220e-04 12 124972503 124972599 97 - 2.569 2.482 -0.293
ENSG00000150990 E033 316.5441544 1.179264e-03 3.323898e-06 2.464782e-05 12 124975419 124975511 93 - 2.497 2.377 -0.399
ENSG00000150990 E034 369.5818966 1.559865e-03 3.865471e-06 2.822081e-05 12 124977342 124977490 149 - 2.564 2.445 -0.399
ENSG00000150990 E035 583.0196932 1.808401e-03 3.882550e-06 2.832677e-05 12 124980490 124980838 349 - 2.753 2.644 -0.362
ENSG00000150990 E036 382.8839946 2.037424e-03 1.004597e-04 5.240032e-04 12 124982511 124982623 113 - 2.569 2.463 -0.353
ENSG00000150990 E037 418.0787410 2.195134e-03 1.759483e-06 1.385522e-05 12 124986096 124986265 170 - 2.626 2.495 -0.437
ENSG00000150990 E038 215.0290706 8.399022e-03 8.786298e-03 2.574928e-02 12 124988917 124989151 235 - 2.334 2.209 -0.416