ENSG00000150961

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000280551 ENSG00000150961 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC24D protein_coding protein_coding 8.597161 6.376011 12.89628 0.5963787 0.4652985 1.015086 4.448188 3.1655933 7.400523 0.3910039 0.5319109 1.222549 0.5241542 0.49363333 0.5733667 0.07973333 3.887317e-01 1.187851e-37 FALSE TRUE
ENST00000511481 ENSG00000150961 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC24D protein_coding protein_coding 8.597161 6.376011 12.89628 0.5963787 0.4652985 1.015086 1.424083 2.6845445 0.000000 0.0753827 0.0000000 -8.073898 0.2064542 0.42730000 0.0000000 -0.42730000 1.187851e-37 1.187851e-37 FALSE TRUE
MSTRG.25383.3 ENSG00000150961 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC24D protein_coding   8.597161 6.376011 12.89628 0.5963787 0.4652985 1.015086 2.523934 0.3952925 5.259801 0.2124865 0.4258840 3.700713 0.2416750 0.05853333 0.4083333 0.34980000 2.380343e-05 1.187851e-37 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000150961 E001 0.5180316 0.0211895266 1.909970e-02 4.955600e-02 4 118722823 118722829 7 - 0.000 0.387 12.489
ENSG00000150961 E002 32.2650335 0.0007021785 4.034181e-11 7.600151e-10 4 118722830 118723023 194 - 1.310 1.734 1.452
ENSG00000150961 E003 171.8866770 0.0087711411 3.368080e-10 5.431330e-09 4 118723024 118723520 497 - 2.075 2.401 1.088
ENSG00000150961 E004 100.4788364 0.0041763620 2.159868e-06 1.667267e-05 4 118723521 118723655 135 - 1.894 2.128 0.785
ENSG00000150961 E005 84.4718801 0.0051089064 5.328001e-04 2.282515e-03 4 118728561 118728650 90 - 1.839 2.029 0.637
ENSG00000150961 E006 0.3686942 0.0374675644 5.897666e-01 7.127971e-01 4 118728651 118728847 197 - 0.087 0.170 1.122
ENSG00000150961 E007 0.6362506 0.4882512086 1.000000e+00 1.000000e+00 4 118729122 118731315 2194 - 0.222 0.171 -0.470
ENSG00000150961 E008 122.1948346 0.0003223352 1.433923e-02 3.900026e-02 4 118731316 118731507 192 - 2.037 2.138 0.338
ENSG00000150961 E009 114.4468539 0.0011191695 3.852779e-01 5.294713e-01 4 118732733 118732912 180 - 2.029 2.081 0.177
ENSG00000150961 E010 0.4815130 0.0203806383 2.333156e-01 3.663534e-01 4 118732913 118733315 403 - 0.087 0.292 2.117
ENSG00000150961 E011 0.4470576 0.0215139005 1.000000e+00 1.000000e+00 4 118735727 118736028 302 - 0.159 0.170 0.116
ENSG00000150961 E012 0.7459213 0.6925361181 5.825052e-01 7.068619e-01 4 118736029 118736551 523 - 0.160 0.308 1.211
ENSG00000150961 E013 0.0000000       4 118736552 118736569 18 -      
ENSG00000150961 E014 0.0000000       4 118738104 118738260 157 -      
ENSG00000150961 E015 84.6632421 0.0020971801 5.909366e-02 1.250725e-01 4 118738261 118738379 119 - 1.881 1.988 0.358
ENSG00000150961 E016 81.9483807 0.0004009912 4.940210e-02 1.080975e-01 4 118739149 118739287 139 - 1.869 1.968 0.336
ENSG00000150961 E017 81.5636219 0.0003684988 6.973466e-02 1.429285e-01 4 118740663 118740808 146 - 1.866 1.960 0.315
ENSG00000150961 E018 63.2914480 0.0031501563 9.251255e-01 9.568781e-01 4 118740941 118741037 97 - 1.783 1.805 0.075
ENSG00000150961 E019 54.2748692 0.0173088275 8.356339e-01 8.972005e-01 4 118743988 118744073 86 - 1.714 1.745 0.105
ENSG00000150961 E020 54.1384919 0.0079677211 3.531194e-01 4.973674e-01 4 118744074 118744158 85 - 1.741 1.700 -0.139
ENSG00000150961 E021 68.4246033 0.0004348151 6.924807e-01 7.937198e-01 4 118744944 118745060 117 - 1.826 1.830 0.013
ENSG00000150961 E022 64.7350599 0.0004145449 9.840210e-02 1.880857e-01 4 118751996 118752089 94 - 1.825 1.771 -0.183
ENSG00000150961 E023 39.9214850 0.0047566796 3.532005e-01 4.974374e-01 4 118752697 118752745 49 - 1.612 1.567 -0.154
ENSG00000150961 E024 61.5007088 0.0022477778 6.247558e-02 1.308099e-01 4 118752746 118752888 143 - 1.807 1.730 -0.263
ENSG00000150961 E025 0.0000000       4 118754033 118754120 88 -      
ENSG00000150961 E026 59.6445737 0.0004538421 4.535204e-02 1.008381e-01 4 118757721 118757845 125 - 1.794 1.718 -0.255
ENSG00000150961 E027 0.0000000       4 118758412 118758627 216 -      
ENSG00000150961 E028 0.1451727 0.0432904027 1.000000e+00   4 118760391 118760607 217 - 0.087 0.000 -8.956
ENSG00000150961 E029 0.2924217 0.0273301531 4.988018e-01   4 118764413 118764801 389 - 0.159 0.000 -9.956
ENSG00000150961 E030 55.1557737 0.0004253698 1.658370e-01 2.827877e-01 4 118764802 118764917 116 - 1.753 1.706 -0.159
ENSG00000150961 E031 0.6244956 0.0594838718 4.928895e-01 6.300066e-01 4 118766529 118766823 295 - 0.159 0.291 1.115
ENSG00000150961 E032 76.0978967 0.0003444889 7.034744e-05 3.817781e-04 4 118768173 118768311 139 - 1.922 1.771 -0.510
ENSG00000150961 E033 0.0000000       4 118769764 118769840 77 -      
ENSG00000150961 E034 72.0015842 0.0003493298 1.267005e-06 1.029466e-05 4 118797683 118797810 128 - 1.909 1.710 -0.672
ENSG00000150961 E035 63.9236150 0.0004012341 1.203373e-09 1.755758e-08 4 118805843 118805954 112 - 1.880 1.600 -0.948
ENSG00000150961 E036 63.0674356 0.0050396238 6.868040e-07 5.907781e-06 4 118815028 118815155 128 - 1.875 1.597 -0.939
ENSG00000150961 E037 8.1425260 0.0444744283 1.623824e-01 2.782382e-01 4 118815156 118815158 3 - 1.011 0.824 -0.707
ENSG00000150961 E038 75.2417651 0.0037454804 4.072727e-05 2.342978e-04 4 118815451 118815626 176 - 1.930 1.735 -0.656
ENSG00000150961 E039 48.5822713 0.0004716803 1.330036e-04 6.721567e-04 4 118815627 118815726 100 - 1.739 1.550 -0.643
ENSG00000150961 E040 0.0000000       4 118816744 118816850 107 -      
ENSG00000150961 E041 57.0101586 0.0007824815 1.723789e-04 8.454583e-04 4 118817264 118817412 149 - 1.803 1.630 -0.584
ENSG00000150961 E042 49.1323044 0.0076758842 1.153676e-02 3.243507e-02 4 118824620 118824749 130 - 1.734 1.582 -0.517
ENSG00000150961 E043 0.0000000       4 118825441 118825618 178 -      
ENSG00000150961 E044 0.0000000       4 118833277 118833578 302 -      
ENSG00000150961 E045 44.9279465 0.0056763966 1.827167e-02 4.772329e-02 4 118833579 118833737 159 - 1.692 1.555 -0.465
ENSG00000150961 E046 23.9827986 0.0138754579 8.110842e-02 1.612762e-01 4 118835941 118836171 231 - 1.429 1.283 -0.509
ENSG00000150961 E047 0.4783925 0.0209833237 1.000000e+00 1.000000e+00 4 118836551 118836614 64 - 0.159 0.170 0.119
ENSG00000150961 E048 0.0000000       4 118838554 118838683 130 -