ENSG00000150938

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000280527 ENSG00000150938 HEK293_OSMI2_2hA HEK293_TMG_2hB CRIM1 protein_coding protein_coding 5.382019 2.461308 8.159617 0.1816863 0.1574804 1.724994 2.3695813 0.5983311 4.0973165 0.1568471 0.1833399 2.7552675 0.3916875 0.2379333 0.5017333 0.26380000 1.318912e-03 5.578035e-08 FALSE TRUE
ENST00000426856 ENSG00000150938 HEK293_OSMI2_2hA HEK293_TMG_2hB CRIM1 protein_coding protein_coding 5.382019 2.461308 8.159617 0.1816863 0.1574804 1.724994 0.5246786 0.0000000 1.1401426 0.0000000 0.1469748 6.8456689 0.0789000 0.0000000 0.1392333 0.13923333 5.578035e-08 5.578035e-08 FALSE FALSE
MSTRG.18211.2 ENSG00000150938 HEK293_OSMI2_2hA HEK293_TMG_2hB CRIM1 protein_coding   5.382019 2.461308 8.159617 0.1816863 0.1574804 1.724994 1.7825061 1.1980523 2.1237010 0.2210374 0.2674632 0.8206751 0.3760750 0.4932333 0.2610000 -0.23223333 1.430998e-01 5.578035e-08 FALSE TRUE
MSTRG.18211.3 ENSG00000150938 HEK293_OSMI2_2hA HEK293_TMG_2hB CRIM1 protein_coding   5.382019 2.461308 8.159617 0.1816863 0.1574804 1.724994 0.6170713 0.4174731 0.7118485 0.1114094 0.1973621 0.7558626 0.1275500 0.1736333 0.0871000 -0.08653333 4.480822e-01 5.578035e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000150938 E001 23.3584159 0.0009057094 3.181949e-05 0.0001881490 2 36355778 36356442 665 + 1.358 1.072 -1.013
ENSG00000150938 E002 11.1168955 0.0015741947 4.066721e-02 0.0922602100 2 36356443 36356470 28 + 1.037 0.889 -0.550
ENSG00000150938 E003 24.6089438 0.0008092988 7.843068e-04 0.0032035657 2 36356471 36356623 153 + 1.367 1.181 -0.652
ENSG00000150938 E004 0.3289534 0.0293828785 3.814369e-01   2 36369115 36369249 135 + 0.063 0.224 2.106
ENSG00000150938 E005 1.0171629 0.9012987112 3.382476e-01 0.4821197822 2 36378357 36378525 169 + 0.118 0.573 3.137
ENSG00000150938 E006 0.0000000       2 36378526 36378853 328 +      
ENSG00000150938 E007 0.5085815 0.2748217229 1.621001e-01 0.2778626881 2 36378854 36378924 71 + 0.063 0.373 3.116
ENSG00000150938 E008 0.0000000       2 36379143 36379224 82 +      
ENSG00000150938 E009 28.1423992 0.0138876492 8.807730e-02 0.1722032781 2 36396614 36396787 174 + 1.398 1.340 -0.201
ENSG00000150938 E010 38.2882299 0.0040589153 9.461781e-04 0.0037754454 2 36441258 36441500 243 + 1.543 1.403 -0.481
ENSG00000150938 E011 32.0125847 0.0006359788 8.182694e-04 0.0033250827 2 36442615 36442735 121 + 1.471 1.327 -0.496
ENSG00000150938 E012 31.4983125 0.0006318208 3.468477e-04 0.0015675667 2 36464534 36464655 122 + 1.466 1.299 -0.579
ENSG00000150938 E013 42.8545803 0.0046112159 1.124439e-02 0.0317482968 2 36476889 36477071 183 + 1.576 1.506 -0.240
ENSG00000150938 E014 20.8432573 0.0100570174 4.633772e-02 0.1026466004 2 36479497 36479542 46 + 1.279 1.182 -0.344
ENSG00000150938 E015 35.1422096 0.0006486955 7.547388e-03 0.0226378629 2 36479543 36479694 152 + 1.493 1.415 -0.270
ENSG00000150938 E016 42.3170884 0.0076995480 1.950108e-04 0.0009425747 2 36499219 36499347 129 + 1.593 1.403 -0.652
ENSG00000150938 E017 0.1817044 0.0405141782 1.356265e-01   2 36499348 36499412 65 + 0.000 0.224 10.766
ENSG00000150938 E018 54.2453605 0.0010675974 5.812794e-03 0.0181204577 2 36509983 36510139 157 + 1.672 1.625 -0.159
ENSG00000150938 E019 37.4857400 0.0043467643 9.680371e-01 0.9840089631 2 36512273 36512394 122 + 1.480 1.589 0.373
ENSG00000150938 E020 34.3898197 0.0039973038 7.103768e-01 0.8075727142 2 36513556 36513689 134 + 1.449 1.533 0.287
ENSG00000150938 E021 25.6438805 0.0031170702 1.703498e-01 0.2886245387 2 36513690 36513765 76 + 1.346 1.341 -0.016
ENSG00000150938 E022 43.4495503 0.0006539271 8.064364e-01 0.8769700295 2 36517327 36517542 216 + 1.537 1.665 0.437
ENSG00000150938 E023 42.8380146 0.0005664149 4.052467e-01 0.5489298162 2 36522092 36522313 222 + 1.521 1.684 0.555
ENSG00000150938 E024 0.0000000       2 36529153 36529512 360 +      
ENSG00000150938 E025 38.2833110 0.0028076875 3.131989e-01 0.4557434051 2 36537352 36537546 195 + 1.506 1.549 0.147
ENSG00000150938 E026 41.5877244 0.0005748835 1.340283e-01 0.2397482102 2 36544376 36544498 123 + 1.546 1.566 0.065
ENSG00000150938 E027 50.3298644 0.0004597473 5.006729e-01 0.6369000613 2 36546984 36547171 188 + 1.613 1.690 0.261
ENSG00000150938 E028 319.9118377 0.0293056021 6.569026e-05 0.0003593343 2 36548525 36551135 2611 + 2.320 2.672 1.175