ENSG00000150867

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376573 ENSG00000150867 HEK293_OSMI2_2hA HEK293_TMG_2hB PIP4K2A protein_coding protein_coding 13.72891 9.886327 18.47186 1.019609 1.027271 0.9011447 9.656915 9.5879768 10.496215 1.0998537 0.3526036 0.1304408 0.75594583 0.9680 0.57353333 -0.39446667 2.084419e-05 1.98043e-26 FALSE TRUE
ENST00000604912 ENSG00000150867 HEK293_OSMI2_2hA HEK293_TMG_2hB PIP4K2A protein_coding protein_coding 13.72891 9.886327 18.47186 1.019609 1.027271 0.9011447 2.900852 0.0000000 6.453052 0.0000000 1.0678160 9.3360718 0.16269583 0.0000 0.34520000 0.34520000 1.980430e-26 1.98043e-26 FALSE FALSE
MSTRG.3656.4 ENSG00000150867 HEK293_OSMI2_2hA HEK293_TMG_2hB PIP4K2A protein_coding   13.72891 9.886327 18.47186 1.019609 1.027271 0.9011447 0.845874 0.2501178 1.409934 0.1124932 0.3463266 2.4485872 0.05463333 0.0269 0.07473333 0.04783333 1.587646e-01 1.98043e-26 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000150867 E001 609.1688207 0.0156570272 1.936673e-07 1.860532e-06 10 22534854 22536737 1884 - 2.608 2.933 1.083
ENSG00000150867 E002 71.1796852 0.0004119007 4.566579e-01 5.970494e-01 10 22536738 22536892 155 - 1.824 1.901 0.260
ENSG00000150867 E003 63.6735524 0.0005473237 1.541710e-02 4.143751e-02 10 22536893 22536965 73 - 1.811 1.812 0.003
ENSG00000150867 E004 50.3058141 0.0013559676 1.488111e-01 2.600577e-01 10 22536966 22537014 49 - 1.695 1.727 0.110
ENSG00000150867 E005 129.5065989 0.0012397491 7.560598e-03 2.267174e-02 10 22537015 22537281 267 - 2.109 2.126 0.057
ENSG00000150867 E006 0.4720498 0.1820884861 7.126660e-01 8.093291e-01 10 22539466 22539635 170 - 0.185 0.145 -0.420
ENSG00000150867 E007 68.5357607 0.0017972153 8.881097e-01 9.324801e-01 10 22539971 22540074 104 - 1.795 1.894 0.334
ENSG00000150867 E008 85.9134140 0.0055996430 9.850181e-01 9.946539e-01 10 22541804 22541951 148 - 1.889 1.993 0.347
ENSG00000150867 E009 82.8863912 0.0115851880 1.105486e-01 2.063339e-01 10 22541952 22542047 96 - 1.924 1.923 -0.001
ENSG00000150867 E010 102.7229495 0.0034511584 7.107021e-03 2.150358e-02 10 22550659 22550772 114 - 2.020 2.006 -0.048
ENSG00000150867 E011 0.0000000       10 22567537 22567770 234 -      
ENSG00000150867 E012 60.8768508 0.0060512698 1.578818e-03 5.890074e-03 10 22567851 22567889 39 - 1.824 1.745 -0.264
ENSG00000150867 E013 0.6695470 0.0176061814 2.516829e-01 3.879498e-01 10 22569013 22569054 42 - 0.103 0.340 2.158
ENSG00000150867 E014 94.6884077 0.0006961414 5.057197e-10 7.907485e-09 10 22573311 22573457 147 - 2.033 1.909 -0.417
ENSG00000150867 E015 82.5525841 0.0003276830 5.500152e-09 7.125674e-08 10 22591629 22591781 153 - 1.972 1.855 -0.394
ENSG00000150867 E016 0.2998086 0.0283719873 9.227816e-01   10 22607818 22607926 109 - 0.103 0.145 0.571
ENSG00000150867 E017 65.5110083 0.0016224654 5.415783e-04 2.315617e-03 10 22607927 22608023 97 - 1.846 1.790 -0.186
ENSG00000150867 E018 55.7977568 0.0031029126 8.178425e-04 3.323562e-03 10 22609620 22609717 98 - 1.787 1.716 -0.240
ENSG00000150867 E019 0.0000000       10 22642022 22642062 41 -      
ENSG00000150867 E020 0.0000000       10 22646219 22646272 54 -      
ENSG00000150867 E021 0.0000000       10 22659610 22659730 121 -      
ENSG00000150867 E022 0.2214452 0.0440000900 4.177924e-01   10 22661743 22661875 133 - 0.000 0.146 9.691
ENSG00000150867 E023 0.0000000       10 22691622 22691830 209 -      
ENSG00000150867 E024 0.3030308 0.3583150414 3.438556e-01   10 22713936 22714182 247 - 0.186 0.000 -9.816
ENSG00000150867 E025 60.8451425 0.0035965355 8.840656e-08 9.066398e-07 10 22714183 22714585 403 - 1.863 1.683 -0.610