ENSG00000150768

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000280346 ENSG00000150768 HEK293_OSMI2_2hA HEK293_TMG_2hB DLAT protein_coding protein_coding 42.72838 26.03383 62.21345 1.179708 1.960072 1.256517 29.0105123 21.075963 40.284302 0.5870638 1.7890345 0.9342930 0.71580833 0.81316667 0.6484333 -0.16473333 1.085411e-01 2.050587e-36 FALSE TRUE
ENST00000679466 ENSG00000150768 HEK293_OSMI2_2hA HEK293_TMG_2hB DLAT protein_coding processed_transcript 42.72838 26.03383 62.21345 1.179708 1.960072 1.256517 9.6813233 0.000000 17.153827 0.0000000 1.9719490 10.7451556 0.17628333 0.00000000 0.2753000 0.27530000 2.050587e-36 2.050587e-36 FALSE TRUE
ENST00000679614 ENSG00000150768 HEK293_OSMI2_2hA HEK293_TMG_2hB DLAT protein_coding protein_coding 42.72838 26.03383 62.21345 1.179708 1.960072 1.256517 0.3366878 1.685948 0.000000 1.6859478 0.0000000 -7.4059480 0.01200417 0.05936667 0.0000000 -0.05936667 6.861595e-01 2.050587e-36 FALSE TRUE
ENST00000681339 ENSG00000150768 HEK293_OSMI2_2hA HEK293_TMG_2hB DLAT protein_coding protein_coding 42.72838 26.03383 62.21345 1.179708 1.960072 1.256517 2.3950945 1.968886 3.212905 0.2227896 0.5913468 0.7036729 0.06238333 0.07566667 0.0512000 -0.02446667 3.238556e-01 2.050587e-36 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000150768 E001 41.8781852 0.0011509846 1.980485e-01 3.237742e-01 11 112025408 112025425 18 + 1.632 1.584 -0.163
ENSG00000150768 E002 54.9002299 0.0015263127 5.835487e-03 1.817916e-02 11 112025426 112025430 5 + 1.772 1.652 -0.408
ENSG00000150768 E003 71.4488950 0.0004673422 8.857765e-07 7.441253e-06 11 112025431 112025439 9 + 1.908 1.710 -0.671
ENSG00000150768 E004 172.0986010 0.0011271183 4.581053e-07 4.082349e-06 11 112025440 112025496 57 + 2.272 2.134 -0.463
ENSG00000150768 E005 279.1381503 0.0068309384 5.330450e-04 2.283513e-03 11 112025497 112025624 128 + 2.479 2.344 -0.451
ENSG00000150768 E006 269.4655644 0.0103943986 3.090966e-02 7.374061e-02 11 112025625 112025751 127 + 2.450 2.357 -0.311
ENSG00000150768 E007 1.8392589 0.0091053565 6.290914e-01 7.445356e-01 11 112025977 112026197 221 + 0.416 0.519 0.516
ENSG00000150768 E008 160.8703202 0.0039181993 4.482029e-04 1.960126e-03 11 112026198 112026230 33 + 2.237 2.111 -0.420
ENSG00000150768 E009 210.9496049 0.0003633560 8.522481e-07 7.185396e-06 11 112026231 112026282 52 + 2.349 2.244 -0.351
ENSG00000150768 E010 146.9047976 0.0002339766 1.095843e-04 5.660800e-04 11 112026283 112026299 17 + 2.189 2.097 -0.309
ENSG00000150768 E011 268.7292278 0.0001699681 3.890757e-06 2.837589e-05 11 112028515 112028639 125 + 2.446 2.369 -0.260
ENSG00000150768 E012 306.0112213 0.0001562603 4.928741e-08 5.320732e-07 11 112028792 112028912 121 + 2.506 2.416 -0.299
ENSG00000150768 E013 208.8894323 0.0001899656 1.353931e-07 1.341167e-06 11 112028913 112028945 33 + 2.348 2.238 -0.368
ENSG00000150768 E014 2.0607027 0.0160815610 1.048244e-01 1.978369e-01 11 112028946 112028976 31 + 0.332 0.627 1.492
ENSG00000150768 E015 290.0717683 0.0002565943 3.183191e-07 2.929399e-06 11 112033404 112033488 85 + 2.482 2.394 -0.294
ENSG00000150768 E016 212.1681433 0.0046557044 1.640437e-02 4.362440e-02 11 112033489 112033530 42 + 2.342 2.271 -0.238
ENSG00000150768 E017 0.9243042 0.0144867796 4.544801e-01 5.951221e-01 11 112033531 112033610 80 + 0.228 0.377 1.001
ENSG00000150768 E018 382.6184700 0.0004136229 3.147375e-04 1.439756e-03 11 112037273 112037460 188 + 2.590 2.544 -0.154
ENSG00000150768 E019 363.7123142 0.0005028234 2.068925e-01 3.348383e-01 11 112039244 112039397 154 + 2.551 2.552 0.004
ENSG00000150768 E020 5.7127082 0.0272037194 8.883593e-01 9.326259e-01 11 112039398 112040861 1464 + 0.799 0.844 0.175
ENSG00000150768 E021 1.3598223 0.0101157109 9.262499e-01 9.575731e-01 11 112042480 112042605 126 + 0.376 0.377 0.002
ENSG00000150768 E022 1.9499763 0.0086141824 7.601737e-01 8.443600e-01 11 112042898 112043465 568 + 0.487 0.453 -0.168
ENSG00000150768 E023 160.3918594 0.0037912816 4.050954e-01 5.487753e-01 11 112043466 112043471 6 + 2.200 2.193 -0.021
ENSG00000150768 E024 283.6521719 0.0009558847 1.545984e-01 2.678759e-01 11 112043472 112043533 62 + 2.447 2.439 -0.026
ENSG00000150768 E025 378.1882774 0.0003606106 9.008747e-01 9.407810e-01 11 112045138 112045230 93 + 2.557 2.588 0.105
ENSG00000150768 E026 369.3411159 0.0001989776 9.024874e-01 9.418918e-01 11 112045863 112045970 108 + 2.546 2.577 0.104
ENSG00000150768 E027 444.5285417 0.0001272236 8.438566e-03 2.488150e-02 11 112051234 112051349 116 + 2.608 2.682 0.248
ENSG00000150768 E028 0.1515154 0.0425014683 9.372532e-01   11 112053048 112053124 77 + 0.090 0.000 -8.323
ENSG00000150768 E029 247.9648369 0.0002258827 2.028432e-01 3.297864e-01 11 112059903 112059923 21 + 2.362 2.421 0.196
ENSG00000150768 E030 479.0579841 0.0004237127 1.213959e-05 7.909918e-05 11 112059924 112060065 142 + 2.625 2.735 0.366
ENSG00000150768 E031 413.9510610 0.0001949939 6.394318e-21 4.564372e-19 11 112061038 112061174 137 + 2.520 2.719 0.663
ENSG00000150768 E032 8.7074876 0.0156637152 1.608536e-01 2.762284e-01 11 112061175 112062405 1231 + 1.028 0.872 -0.584
ENSG00000150768 E033 1677.8515839 0.0058304554 3.395354e-06 2.511911e-05 11 112062406 112064404 1999 + 3.139 3.310 0.567