ENSG00000150764

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000440460 ENSG00000150764 HEK293_OSMI2_2hA HEK293_TMG_2hB DIXDC1 protein_coding protein_coding 2.408055 1.698336 3.310047 0.1255761 0.1309854 0.9586115 1.62766668 0.50363038 2.50779741 0.08164234 0.15362454 2.2933598 0.63033333 0.29666667 0.756766667 0.46010000 5.573420e-08 5.57342e-08 FALSE TRUE
ENST00000526418 ENSG00000150764 HEK293_OSMI2_2hA HEK293_TMG_2hB DIXDC1 protein_coding retained_intron 2.408055 1.698336 3.310047 0.1255761 0.1309854 0.9586115 0.09902375 0.42150063 0.01227246 0.22586857 0.01227246 -4.2760301 0.05925000 0.23723333 0.004033333 -0.23320000 1.079079e-01 5.57342e-08   FALSE
ENST00000526500 ENSG00000150764 HEK293_OSMI2_2hA HEK293_TMG_2hB DIXDC1 protein_coding retained_intron 2.408055 1.698336 3.310047 0.1255761 0.1309854 0.9586115 0.06289592 0.27314573 0.00000000 0.27314573 0.00000000 -4.8234729 0.03696667 0.17220000 0.000000000 -0.17220000 7.217057e-01 5.57342e-08 FALSE TRUE
ENST00000529225 ENSG00000150764 HEK293_OSMI2_2hA HEK293_TMG_2hB DIXDC1 protein_coding protein_coding 2.408055 1.698336 3.310047 0.1255761 0.1309854 0.9586115 0.31058283 0.45028479 0.33210812 0.03995378 0.05819802 -0.4280744 0.14567917 0.26620000 0.099333333 -0.16686667 3.944182e-03 5.57342e-08 FALSE TRUE
ENST00000615255 ENSG00000150764 HEK293_OSMI2_2hA HEK293_TMG_2hB DIXDC1 protein_coding protein_coding 2.408055 1.698336 3.310047 0.1255761 0.1309854 0.9586115 0.24230440 0.04977485 0.39281590 0.02715165 0.13407155 2.7525102 0.09763333 0.02773333 0.121000000 0.09326667 2.608512e-01 5.57342e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000150764 E001 0.0000000       11 111926988 111927143 156 +      
ENSG00000150764 E002 2.2820356 0.0066702088 8.254811e-02 1.635292e-01 11 111927144 111927387 244 + 0.381 0.671 1.391
ENSG00000150764 E003 2.2496566 0.1037439900 2.875269e-01 4.280301e-01 11 111929818 111929910 93 + 0.416 0.619 0.974
ENSG00000150764 E004 5.1431583 0.0039383256 1.705546e-01 2.888762e-01 11 111937343 111937419 77 + 0.821 0.619 -0.833
ENSG00000150764 E005 7.1724138 0.0322733295 7.314274e-01 8.230823e-01 11 111937420 111937559 140 + 0.905 0.861 -0.166
ENSG00000150764 E006 12.6378396 0.0036103864 7.752084e-01 8.551601e-01 11 111964549 111964678 130 + 1.102 1.134 0.116
ENSG00000150764 E007 14.6956892 0.0057266075 4.607502e-01 6.007457e-01 11 111968513 111968638 126 + 1.189 1.118 -0.256
ENSG00000150764 E008 19.3815675 0.0010415796 9.290616e-01 9.594014e-01 11 111974023 111974254 232 + 1.281 1.277 -0.014
ENSG00000150764 E009 0.0000000       11 111974255 111974367 113 +      
ENSG00000150764 E010 12.4011525 0.0014724059 6.094950e-01 7.289905e-01 11 111974876 111974983 108 + 1.081 1.135 0.194
ENSG00000150764 E011 13.0858467 0.0016741838 6.608833e-12 1.417439e-10 11 111974984 111975995 1012 + 0.808 1.445 2.308
ENSG00000150764 E012 0.2944980 0.3583726064 7.407445e-01   11 111976906 111977007 102 + 0.147 0.000 -8.825
ENSG00000150764 E013 2.4077448 0.0084280916 4.063361e-01 5.499938e-01 11 111977309 111977794 486 + 0.558 0.412 -0.726
ENSG00000150764 E014 11.3643388 0.0015485616 3.392373e-03 1.141579e-02 11 111980737 111980849 113 + 1.142 0.797 -1.287
ENSG00000150764 E015 0.0000000       11 111982217 111982338 122 +      
ENSG00000150764 E016 16.2737062 0.0013506153 2.011657e-03 7.262274e-03 11 111982339 111982487 149 + 1.281 0.975 -1.101
ENSG00000150764 E017 12.8865183 0.0024638265 6.461070e-06 4.484455e-05 11 111985232 111985321 90 + 1.227 0.671 -2.106
ENSG00000150764 E018 9.9762386 0.0016691463 8.167193e-02 1.621737e-01 11 111986871 111986924 54 + 1.066 0.865 -0.752
ENSG00000150764 E019 0.0000000       11 111988947 111989004 58 +      
ENSG00000150764 E020 11.8355328 0.0015378735 5.033377e-02 1.097567e-01 11 111989005 111989055 51 + 1.136 0.923 -0.779
ENSG00000150764 E021 15.2219066 0.0012275373 5.499790e-02 1.179936e-01 11 111992415 111992519 105 + 1.227 1.042 -0.665
ENSG00000150764 E022 11.4740450 0.0018155553 2.586827e-01 3.959943e-01 11 111992951 111993004 54 + 1.095 0.975 -0.441
ENSG00000150764 E023 12.1367975 0.0388224098 5.265917e-01 6.597959e-01 11 111993496 111993588 93 + 1.115 1.023 -0.336
ENSG00000150764 E024 9.8635717 0.0091440774 1.990138e-01 3.249829e-01 11 111993669 111993729 61 + 1.051 0.895 -0.582
ENSG00000150764 E025 8.1618951 0.0021448707 2.431749e-01 3.779070e-01 11 111993730 111993740 11 + 0.975 0.832 -0.542
ENSG00000150764 E026 13.7353877 0.0013725387 2.698268e-02 6.595941e-02 11 111995019 111995108 90 + 1.201 0.975 -0.819
ENSG00000150764 E027 16.5857754 0.0197099485 8.985537e-03 2.624428e-02 11 111995403 111995564 162 + 1.290 0.976 -1.131
ENSG00000150764 E028 12.3427328 0.0136973714 5.468404e-02 1.174413e-01 11 111996080 111996146 67 + 1.155 0.923 -0.847
ENSG00000150764 E029 0.0000000       11 111996147 111996325 179 +      
ENSG00000150764 E030 16.8173010 0.0072783800 1.288732e-02 3.565222e-02 11 112016691 112016796 106 + 1.290 1.041 -0.890
ENSG00000150764 E031 0.1515154 0.0427449988 1.000000e+00   11 112017574 112017776 203 + 0.080 0.000 -8.524
ENSG00000150764 E032 17.4540768 0.0011139444 1.042274e-02 2.980149e-02 11 112017777 112017885 109 + 1.299 1.062 -0.842
ENSG00000150764 E033 193.2763350 0.0006184456 3.579543e-16 1.433383e-14 11 112018956 112022653 3698 + 2.197 2.373 0.587