ENSG00000150756

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000280330 ENSG00000150756 HEK293_OSMI2_2hA HEK293_TMG_2hB ATPSCKMT protein_coding protein_coding 9.944147 6.338204 14.52761 0.285156 0.760696 1.19537 1.8898187 1.8898785 2.763815 0.1683431 0.14998531 0.5459642 0.1828583 0.29766667 0.1920333 -0.10563333 0.04840906 0.04840906   FALSE
ENST00000510047 ENSG00000150756 HEK293_OSMI2_2hA HEK293_TMG_2hB ATPSCKMT protein_coding protein_coding 9.944147 6.338204 14.52761 0.285156 0.760696 1.19537 1.9178888 0.3728492 4.018806 0.3728492 0.32893410 3.3955040 0.1509792 0.06420000 0.2758667 0.21166667 0.10948162 0.04840906 FALSE TRUE
ENST00000511437 ENSG00000150756 HEK293_OSMI2_2hA HEK293_TMG_2hB ATPSCKMT protein_coding protein_coding 9.944147 6.338204 14.52761 0.285156 0.760696 1.19537 1.8402613 1.4160741 1.877447 0.3254588 0.03463158 0.4043875 0.2271750 0.22000000 0.1296667 -0.09033333 0.14569077 0.04840906 FALSE TRUE
MSTRG.25929.2 ENSG00000150756 HEK293_OSMI2_2hA HEK293_TMG_2hB ATPSCKMT protein_coding   9.944147 6.338204 14.52761 0.285156 0.760696 1.19537 2.3751555 0.3738176 4.003383 0.3738176 0.33864747 3.3863260 0.2000708 0.06436667 0.2787667 0.21440000 0.11233962 0.04840906 TRUE TRUE
MSTRG.25929.3 ENSG00000150756 HEK293_OSMI2_2hA HEK293_TMG_2hB ATPSCKMT protein_coding   9.944147 6.338204 14.52761 0.285156 0.760696 1.19537 0.5818839 1.1560807 0.000000 0.5939447 0.00000000 -6.8655238 0.0929875 0.17456667 0.0000000 -0.17456667 0.08400659 0.04840906 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000150756 E001 0.9587465 0.0142743674 1.324546e-01 2.374939e-01 5 10209376 10209471 96 - 0.171 0.440 1.866
ENSG00000150756 E002 3.0583613 0.0716285099 4.696593e-01 6.088877e-01 5 10223995 10224061 67 - 0.533 0.660 0.569
ENSG00000150756 E003 22.1177874 0.0009219087 1.098898e-01 2.053833e-01 5 10225507 10226329 823 - 1.307 1.430 0.428
ENSG00000150756 E004 106.0015315 0.0028266531 1.198563e-06 9.788937e-06 5 10226330 10226955 626 - 1.937 2.133 0.656
ENSG00000150756 E005 57.1200723 0.0004547233 9.731823e-04 3.867395e-03 5 10226956 10227280 325 - 1.692 1.848 0.527
ENSG00000150756 E006 97.4598165 0.0003209741 1.281516e-02 3.547849e-02 5 10227281 10227557 277 - 2.015 1.936 -0.267
ENSG00000150756 E007 46.9527269 0.0005667172 2.821929e-03 9.739587e-03 5 10227558 10227579 22 - 1.725 1.574 -0.512
ENSG00000150756 E008 49.0941844 0.0004855635 8.255497e-03 2.443065e-02 5 10227580 10227609 30 - 1.736 1.608 -0.435
ENSG00000150756 E009 52.5187591 0.0004442268 7.347216e-02 1.490840e-01 5 10227610 10227647 38 - 1.750 1.669 -0.271
ENSG00000150756 E010 36.0239952 0.0005705543 1.599935e-01 2.751104e-01 5 10235211 10235261 51 - 1.589 1.514 -0.257
ENSG00000150756 E011 2.3595704 0.0064625749 4.580184e-01 5.983410e-01 5 10236148 10236477 330 - 0.562 0.441 -0.591
ENSG00000150756 E012 43.5817991 0.0004987813 2.081234e-01 3.362157e-01 5 10236478 10236521 44 - 1.663 1.603 -0.204
ENSG00000150756 E013 60.0260347 0.0005597371 9.615023e-01 9.797530e-01 5 10236522 10236615 94 - 1.778 1.784 0.018
ENSG00000150756 E014 0.0000000       5 10236838 10237040 203 -      
ENSG00000150756 E015 1.0276452 0.0325681572 1.347405e-01 2.407308e-01 5 10239042 10239066 25 - 0.171 0.441 1.870
ENSG00000150756 E016 89.0289525 0.0003281662 8.528840e-01 9.088401e-01 5 10239067 10239356 290 - 1.948 1.949 0.003
ENSG00000150756 E017 0.1515154 0.0425618990 8.769512e-01   5 10244434 10244500 67 - 0.094 0.000 -8.210
ENSG00000150756 E018 19.0770876 0.0010276193 5.731930e-01 6.991748e-01 5 10249858 10249897 40 - 1.307 1.269 -0.132
ENSG00000150756 E019 3.7060523 0.0287407879 7.379142e-01 8.279573e-01 5 10249952 10250100 149 - 0.641 0.695 0.229