ENSG00000150753

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000280326 ENSG00000150753 HEK293_OSMI2_2hA HEK293_TMG_2hB CCT5 protein_coding protein_coding 306.0276 168.7832 440.6708 13.81011 1.93404 1.384478 152.76050 116.3791758 196.33641 11.2830273 4.223503 0.7544443 0.53645000 0.689433333 0.44550000 -0.24393333 5.715946e-07 5.715946e-07 FALSE TRUE
ENST00000503454 ENSG00000150753 HEK293_OSMI2_2hA HEK293_TMG_2hB CCT5 protein_coding nonsense_mediated_decay 306.0276 168.7832 440.6708 13.81011 1.93404 1.384478 55.96321 23.5783164 81.46831 3.3114761 4.387737 1.7883436 0.17100417 0.138900000 0.18496667 0.04606667 1.766057e-01 5.715946e-07 FALSE FALSE
ENST00000508451 ENSG00000150753 HEK293_OSMI2_2hA HEK293_TMG_2hB CCT5 protein_coding retained_intron 306.0276 168.7832 440.6708 13.81011 1.93404 1.384478 23.99697 0.7875727 46.08789 0.5633537 4.239265 5.8529408 0.05891250 0.005266667 0.10456667 0.09930000 1.291917e-04 5.715946e-07 FALSE TRUE
ENST00000511700 ENSG00000150753 HEK293_OSMI2_2hA HEK293_TMG_2hB CCT5 protein_coding nonsense_mediated_decay 306.0276 168.7832 440.6708 13.81011 1.93404 1.384478 40.74160 16.5106787 66.71545 0.9161391 2.453101 2.0139641 0.12707917 0.098300000 0.15143333 0.05313333 1.170840e-05 5.715946e-07 FALSE FALSE
ENST00000512975 ENSG00000150753 HEK293_OSMI2_2hA HEK293_TMG_2hB CCT5 protein_coding nonsense_mediated_decay 306.0276 168.7832 440.6708 13.81011 1.93404 1.384478 18.06601 3.7478446 28.38925 3.7478446 3.161768 2.9178753 0.05417083 0.021766667 0.06436667 0.04260000 1.165429e-01 5.715946e-07 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000150753 E001 2.249781 6.556999e-03 2.385169e-02 5.950153e-02 5 10249929 10250045 117 + 0.296 0.691 2.002
ENSG00000150753 E002 42.991924 8.029913e-03 1.127798e-01 2.095994e-01 5 10250216 10250242 27 + 1.667 1.584 -0.283
ENSG00000150753 E003 149.851136 5.619169e-04 5.168841e-07 4.558971e-06 5 10250243 10250279 37 + 2.219 2.093 -0.424
ENSG00000150753 E004 407.315873 2.271335e-03 4.921813e-04 2.130375e-03 5 10250280 10250308 29 + 2.633 2.558 -0.250
ENSG00000150753 E005 454.606289 1.384819e-03 5.640076e-05 3.136229e-04 5 10250309 10250318 10 + 2.679 2.609 -0.234
ENSG00000150753 E006 824.594350 1.012906e-03 5.159361e-06 3.660633e-05 5 10250319 10250340 22 + 2.934 2.872 -0.207
ENSG00000150753 E007 1027.940448 8.990926e-04 1.007261e-05 6.687082e-05 5 10250341 10250359 19 + 3.026 2.974 -0.173
ENSG00000150753 E008 1681.576173 2.742674e-04 4.855729e-20 3.096275e-18 5 10250360 10250445 86 + 3.249 3.173 -0.253
ENSG00000150753 E009 1.643375 1.314572e-01 9.376864e-03 2.722523e-02 5 10250537 10250538 2 + 0.567 0.001 -10.979
ENSG00000150753 E010 7.041620 1.541088e-02 2.199710e-05 1.350559e-04 5 10250539 10250893 355 + 1.061 0.437 -2.598
ENSG00000150753 E011 1784.094615 4.317129e-04 1.867793e-15 6.816564e-14 5 10254145 10254205 61 + 3.273 3.200 -0.243
ENSG00000150753 E012 13.295744 3.906528e-02 7.295889e-03 2.199096e-02 5 10254206 10254584 379 + 1.258 0.900 -1.303
ENSG00000150753 E013 2406.965487 2.006924e-04 3.441513e-21 2.523159e-19 5 10254674 10254765 92 + 3.399 3.340 -0.198
ENSG00000150753 E014 1545.509142 1.240108e-04 3.660362e-07 3.327469e-06 5 10254766 10254795 30 + 3.192 3.173 -0.062
ENSG00000150753 E015 1937.090466 9.189663e-05 5.853959e-20 3.694254e-18 5 10254796 10254838 43 + 3.302 3.252 -0.165
ENSG00000150753 E016 11.153867 2.208319e-02 1.806943e-04 8.809281e-04 5 10254839 10255030 192 + 1.208 0.730 -1.794
ENSG00000150753 E017 3321.747485 2.054896e-04 9.157965e-08 9.361909e-07 5 10255955 10256153 199 + 3.522 3.507 -0.049
ENSG00000150753 E018 1.332856 9.778410e-03 7.348043e-02 1.490944e-01 5 10257886 10258110 225 + 0.470 0.156 -2.170
ENSG00000150753 E019 3075.338436 4.251470e-04 1.838005e-03 6.720799e-03 5 10258111 10258303 193 + 3.484 3.479 -0.017
ENSG00000150753 E020 2570.203967 2.871999e-04 8.677447e-01 9.189249e-01 5 10258386 10258535 150 + 3.391 3.423 0.109
ENSG00000150753 E021 2480.812686 6.782232e-04 9.428384e-03 2.735175e-02 5 10260792 10260911 120 + 3.361 3.425 0.214
ENSG00000150753 E022 22.454722 7.912158e-04 1.865941e-03 6.808887e-03 5 10260912 10261187 276 + 1.437 1.232 -0.715
ENSG00000150753 E023 2945.089992 5.928193e-04 1.715989e-09 2.434576e-08 5 10261560 10261745 186 + 3.416 3.523 0.356
ENSG00000150753 E024 28.142935 1.603412e-02 4.888524e-06 3.488591e-05 5 10261746 10261974 229 + 1.580 1.161 -1.456
ENSG00000150753 E025 66.102275 3.762948e-03 1.564784e-06 1.245667e-05 5 10261975 10262480 506 + 1.901 1.671 -0.777
ENSG00000150753 E026 2557.250586 4.685060e-04 9.572348e-21 6.709037e-19 5 10262481 10262618 138 + 3.337 3.483 0.486
ENSG00000150753 E027 3329.549783 1.448022e-03 2.406509e-08 2.760891e-07 5 10263134 10263314 181 + 3.456 3.590 0.446
ENSG00000150753 E028 3179.375887 2.205106e-03 6.042531e-09 7.772010e-08 5 10264656 10266389 1734 + 3.423 3.584 0.536