ENSG00000150712

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264934 ENSG00000150712 HEK293_OSMI2_2hA HEK293_TMG_2hB MTMR12 protein_coding protein_coding 8.610917 4.153715 12.60135 0.3044558 0.5037424 1.598779 1.011760 0.2114327 1.801369 0.08060731 0.09161966 3.032141 0.08965417 0.0517000 0.1430333 0.09133333 0.01644644 0.01644644 FALSE  
ENST00000382142 ENSG00000150712 HEK293_OSMI2_2hA HEK293_TMG_2hB MTMR12 protein_coding protein_coding 8.610917 4.153715 12.60135 0.3044558 0.5037424 1.598779 6.683473 3.6672407 9.565230 0.29919611 0.24154066 1.380684 0.80983333 0.8828667 0.7606000 -0.12226667 0.07365870 0.01644644 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000150712 E001 0.2934659 0.0286018203 4.983341e-01   5 32226994 32227006 13 - 0.076 0.191 1.523
ENSG00000150712 E002 459.7894638 0.0103057813 2.909673e-04 1.343086e-03 5 32227007 32229607 2601 - 2.559 2.750 0.635
ENSG00000150712 E003 158.0571031 0.0002834253 1.369441e-01 2.438244e-01 5 32229608 32230084 477 - 2.133 2.233 0.334
ENSG00000150712 E004 112.6784243 0.0014708514 9.460665e-02 1.822901e-01 5 32230085 32230347 263 - 1.979 2.097 0.398
ENSG00000150712 E005 2.1989705 0.0869233735 6.457253e-01 7.577989e-01 5 32232961 32233020 60 - 0.494 0.425 -0.350
ENSG00000150712 E006 69.0635341 0.0004749879 6.599123e-01 7.686487e-01 5 32233773 32233934 162 - 1.795 1.831 0.122
ENSG00000150712 E007 54.9856061 0.0164496810 5.155356e-01 6.501922e-01 5 32234962 32235129 168 - 1.708 1.704 -0.013
ENSG00000150712 E008 58.4390558 0.0018211781 7.026850e-01 8.014929e-01 5 32239001 32239173 173 - 1.724 1.758 0.116
ENSG00000150712 E009 33.3034946 0.0014642270 7.405859e-01 8.299621e-01 5 32242057 32242127 71 - 1.471 1.547 0.261
ENSG00000150712 E010 38.0289941 0.0005903463 8.931686e-01 9.357355e-01 5 32243521 32243599 79 - 1.539 1.586 0.162
ENSG00000150712 E011 49.3334225 0.0177735743 6.372315e-01 7.511626e-01 5 32248002 32248126 125 - 1.657 1.669 0.039
ENSG00000150712 E012 42.4059551 0.0006635121 3.059963e-01 4.481403e-01 5 32248772 32248878 107 - 1.597 1.592 -0.016
ENSG00000150712 E013 37.8343043 0.0006025231 5.502878e-03 1.729522e-02 5 32255693 32255768 76 - 1.587 1.465 -0.417
ENSG00000150712 E014 0.1515154 0.0434578176 1.000000e+00   5 32255769 32255937 169 - 0.076 0.001 -6.771
ENSG00000150712 E015 55.0869729 0.0005406048 1.381837e-05 8.885512e-05 5 32263113 32263242 130 - 1.760 1.579 -0.614
ENSG00000150712 E016 46.6400807 0.0004648180 1.240061e-05 8.063079e-05 5 32268701 32268794 94 - 1.693 1.489 -0.697
ENSG00000150712 E017 52.2144862 0.0005440390 5.684401e-05 3.157809e-04 5 32270817 32270947 131 - 1.735 1.567 -0.572
ENSG00000150712 E018 40.5298867 0.0012855253 7.193270e-02 1.465457e-01 5 32271833 32271905 73 - 1.601 1.546 -0.187
ENSG00000150712 E019 50.4648562 0.0005125239 1.307535e-04 6.620744e-04 5 32273980 32274122 143 - 1.719 1.560 -0.541
ENSG00000150712 E020 31.6454677 0.0006728378 2.499277e-04 1.174979e-03 5 32276682 32276742 61 - 1.529 1.320 -0.723
ENSG00000150712 E021 0.8942144 0.2080321289 1.925436e-01 3.169526e-01 5 32296354 32296470 117 - 0.141 0.428 2.128
ENSG00000150712 E022 32.4466784 0.0006455087 6.761641e-07 5.823927e-06 5 32312758 32312987 230 - 1.560 1.245 -1.091