ENSG00000150636

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000580292 ENSG00000150636 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC102B protein_coding processed_transcript 2.84693 3.481734 2.705617 0.8425523 0.4280297 -0.3626637 0.49942113 0.2313535 0.9820563 0.09905894 0.08787752 2.03927421 0.20072917 0.0608000 0.37196667 0.31116667 1.251605e-07 1.251605e-07   FALSE
ENST00000582077 ENSG00000150636 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC102B protein_coding processed_transcript 2.84693 3.481734 2.705617 0.8425523 0.4280297 -0.3626637 0.47855765 0.6483117 0.6205708 0.19110698 0.13159349 -0.06211245 0.19132083 0.1844333 0.22593333 0.04150000 6.819018e-01 1.251605e-07   FALSE
ENST00000584156 ENSG00000150636 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC102B protein_coding protein_coding 2.84693 3.481734 2.705617 0.8425523 0.4280297 -0.3626637 0.07478418 0.0000000 0.1289367 0.00000000 0.03785050 3.79635613 0.02245833 0.0000000 0.05283333 0.05283333 7.407200e-03 1.251605e-07 FALSE TRUE
ENST00000584775 ENSG00000150636 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC102B protein_coding protein_coding 2.84693 3.481734 2.705617 0.8425523 0.4280297 -0.3626637 0.11550554 0.0000000 0.3539498 0.00000000 0.08895578 5.18566773 0.05633333 0.0000000 0.14083333 0.14083333 2.995392e-05 1.251605e-07 FALSE TRUE
MSTRG.15898.5 ENSG00000150636 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC102B protein_coding   2.84693 3.481734 2.705617 0.8425523 0.4280297 -0.3626637 1.39737658 2.3480885 0.2401444 0.54479115 0.24014440 -3.23678483 0.40812083 0.6759333 0.06746667 -0.60846667 1.014320e-02 1.251605e-07   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000150636 E001 1.3337980 0.011471468 7.221813e-01 0.8163634860 18 68715209 68715234 26 + 0.376 0.404 0.157
ENSG00000150636 E002 5.4279474 0.003650027 2.403292e-02 0.0598829945 18 68715235 68715274 40 + 0.710 0.938 0.894
ENSG00000150636 E003 9.5731874 0.002126996 2.881493e-03 0.0099155403 18 68715275 68715312 38 + 0.912 1.148 0.868
ENSG00000150636 E004 13.9534027 0.002295945 2.281147e-04 0.0010837237 18 68715313 68715361 49 + 1.059 1.305 0.875
ENSG00000150636 E005 4.5547232 0.052378213 6.771973e-01 0.7819740341 18 68715362 68715611 250 + 0.753 0.747 -0.027
ENSG00000150636 E006 15.1713367 0.001494568 4.882194e-03 0.0156019860 18 68716528 68716594 67 + 1.135 1.297 0.573
ENSG00000150636 E007 7.1028626 0.003859526 1.715809e-03 0.0063316619 18 68718004 68718130 127 + 0.754 1.056 1.148
ENSG00000150636 E008 4.3491883 0.004009017 1.050064e-01 0.1981052883 18 68734734 68734766 33 + 0.849 0.567 -1.171
ENSG00000150636 E009 25.5393298 0.004412310 2.175973e-04 0.0010392042 18 68753296 68755005 1710 + 1.549 1.242 -1.064
ENSG00000150636 E010 0.2966881 0.028320364 4.102256e-01   18 68798080 68798181 102 + 0.190 0.000 -13.460
ENSG00000150636 E011 0.0000000       18 68798415 68798452 38 +      
ENSG00000150636 E012 0.0000000       18 68823366 68823373 8 +      
ENSG00000150636 E013 0.1482932 0.041159753 2.945163e-01   18 68823374 68823416 43 + 0.000 0.141 12.286
ENSG00000150636 E014 0.5869198 0.162573721 1.578352e-01 0.2722392821 18 68836749 68836763 15 + 0.322 0.000 -14.173
ENSG00000150636 E015 4.1876340 0.022455455 3.423537e-05 0.0002007114 18 68836764 68837369 606 + 0.926 0.141 -4.272
ENSG00000150636 E016 3.1285508 0.341642648 5.544299e-03 0.0174031692 18 68838706 68838926 221 + 0.833 0.000 -15.684
ENSG00000150636 E017 1.1907914 0.327787361 5.951253e-02 0.1257876237 18 68846313 68846363 51 + 0.506 0.000 -14.813
ENSG00000150636 E018 0.4417471 0.729812317 5.221370e-01 0.6559892882 18 68846364 68846394 31 + 0.261 0.000 -13.526
ENSG00000150636 E019 0.4417471 0.729812317 5.221370e-01 0.6559892882 18 68846395 68846421 27 + 0.261 0.000 -13.526
ENSG00000150636 E020 1.6952071 0.008496520 1.533823e-01 0.2662767577 18 68874669 68874785 117 + 0.541 0.248 -1.687
ENSG00000150636 E021 0.0000000       18 68874786 68874965 180 +      
ENSG00000150636 E022 2.4315659 0.006423967 2.261831e-02 0.0569590403 18 68897219 68897428 210 + 0.686 0.248 -2.324
ENSG00000150636 E023 0.0000000       18 68897429 68897577 149 +      
ENSG00000150636 E024 0.3289534 0.030149974 7.095845e-01   18 68897578 68897793 216 + 0.106 0.141 0.484
ENSG00000150636 E025 0.5911862 0.019387492 1.138799e-01 0.2111825451 18 69010934 69011104 171 + 0.322 0.000 -14.269
ENSG00000150636 E026 0.0000000       18 69011105 69011224 120 +      
ENSG00000150636 E027 0.2987644 0.030389423 4.093700e-01   18 69054030 69055189 1160 + 0.191 0.000 -13.459