ENSG00000150627

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000443118 ENSG00000150627 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR17 protein_coding protein_coding 1.906505 0.3798176 3.01794 0.1109133 0.04719124 2.957465 0.02445597 0.05030294 0.00000000 0.05030294 0.000000000 -2.592228 0.05602917 0.1490667 0.00000000 -0.14906667 0.375511170 0.001499151 FALSE TRUE
ENST00000505894 ENSG00000150627 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR17 protein_coding protein_coding 1.906505 0.3798176 3.01794 0.1109133 0.04719124 2.957465 0.01075894 0.08607155 0.00000000 0.08607155 0.000000000 -3.264109 0.01825000 0.1460000 0.00000000 -0.14600000 0.268946345 0.001499151 FALSE FALSE
ENST00000508596 ENSG00000150627 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR17 protein_coding protein_coding 1.906505 0.3798176 3.01794 0.1109133 0.04719124 2.957465 0.27802919 0.11560992 0.47615949 0.05829859 0.029066990 1.952479 0.14929583 0.2749000 0.15753333 -0.11736667 0.528231631 0.001499151 FALSE TRUE
MSTRG.25749.10 ENSG00000150627 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR17 protein_coding   1.906505 0.3798176 3.01794 0.1109133 0.04719124 2.957465 0.56206058 0.00000000 0.74726907 0.00000000 0.253313694 6.242734 0.26845000 0.0000000 0.24636667 0.24636667 0.033998308 0.001499151 TRUE TRUE
MSTRG.25749.12 ENSG00000150627 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR17 protein_coding   1.906505 0.3798176 3.01794 0.1109133 0.04719124 2.957465 0.09025014 0.05701994 0.04145743 0.05701994 0.001879234 -0.381211 0.06765000 0.0967000 0.01373333 -0.08296667 0.169865076 0.001499151 FALSE TRUE
MSTRG.25749.3 ENSG00000150627 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR17 protein_coding   1.906505 0.3798176 3.01794 0.1109133 0.04719124 2.957465 0.50838242 0.00000000 1.09505008 0.00000000 0.223549761 6.787968 0.16562500 0.0000000 0.36380000 0.36380000 0.001499151 0.001499151 FALSE TRUE
MSTRG.25749.5 ENSG00000150627 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR17 protein_coding   1.906505 0.3798176 3.01794 0.1109133 0.04719124 2.957465 0.22916291 0.00000000 0.29047945 0.00000000 0.159885065 4.909194 0.13920417 0.0000000 0.09523333 0.09523333 0.669181405 0.001499151 FALSE TRUE
MSTRG.25749.6 ENSG00000150627 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR17 protein_coding   1.906505 0.3798176 3.01794 0.1109133 0.04719124 2.957465 0.08140605 0.07081329 0.31974434 0.07081329 0.204391490 2.028683 0.06541250 0.3333333 0.10783333 -0.22550000 0.970776883 0.001499151 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000150627 E001 0.3030308 0.3522366437 1.000000e+00   4 176065841 176065876 36 + 0.092 0.000 -8.099
ENSG00000150627 E002 0.3030308 0.3522366437 1.000000e+00   4 176065877 176065882 6 + 0.092 0.000 -10.125
ENSG00000150627 E003 0.5954526 0.0172671820 1.000000e+00 1.000000e+00 4 176065883 176065980 98 + 0.167 0.000 -11.496
ENSG00000150627 E004 2.6906887 0.0059055176 4.517557e-01 5.926813e-01 4 176065981 176066079 99 + 0.422 0.569 0.718
ENSG00000150627 E005 0.2934659 0.0298146759 1.401403e-01   4 176068220 176068278 59 + 0.048 0.279 2.937
ENSG00000150627 E006 0.4751703 0.0209451595 2.255223e-02 5.682964e-02 4 176068279 176068348 70 + 0.048 0.447 3.938
ENSG00000150627 E007 0.7708142 0.0153298673 5.626189e-01 6.901860e-01 4 176068349 176068386 38 + 0.167 0.279 0.939
ENSG00000150627 E008 0.5891098 0.0182611285 1.000000e+00 1.000000e+00 4 176096463 176096484 22 + 0.167 0.000 -11.494
ENSG00000150627 E009 0.8857980 0.0139152451 5.473487e-01 6.774126e-01 4 176096485 176096509 25 + 0.232 0.000 -11.949
ENSG00000150627 E010 1.7853255 0.0533983349 7.509656e-01 8.375170e-01 4 176096510 176096585 76 + 0.361 0.278 -0.526
ENSG00000150627 E011 0.1472490 0.0438041944 7.168714e-01   4 176111208 176111293 86 + 0.048 0.000 -9.711
ENSG00000150627 E012 8.5361048 0.0025608896 5.129172e-01 6.477955e-01 4 176111575 176111703 129 + 0.822 0.914 0.354
ENSG00000150627 E013 14.3589118 0.0242282637 1.280131e-01 2.313895e-01 4 176115796 176115979 184 + 1.064 0.806 -0.971
ENSG00000150627 E014 16.6063704 0.0012159029 2.455447e-02 6.096046e-02 4 176119867 176120097 231 + 1.129 0.807 -1.204
ENSG00000150627 E015 6.2569742 0.0029708824 6.917288e-01 7.931555e-01 4 176125104 176125154 51 + 0.738 0.663 -0.310
ENSG00000150627 E016 9.3476841 0.0017930528 1.625717e-02 4.329067e-02 4 176125155 176125355 201 + 0.912 0.448 -1.992
ENSG00000150627 E017 1.2015143 0.2274595230 4.795834e-01 6.179479e-01 4 176126906 176126941 36 + 0.289 0.000 -11.992
ENSG00000150627 E018 0.4482035 0.0266410397 1.000000e+00 1.000000e+00 4 176126946 176126977 32 + 0.131 0.000 -11.142
ENSG00000150627 E019 8.0007696 0.0158845765 4.782957e-02 1.053208e-01 4 176128738 176128860 123 + 0.852 0.447 -1.762
ENSG00000150627 E020 15.8523633 0.0021401130 3.195636e-01 4.626488e-01 4 176131554 176131738 185 + 1.093 0.959 -0.491
ENSG00000150627 E021 14.3437187 0.0013098021 5.348862e-01 6.668661e-01 4 176135108 176135276 169 + 1.046 0.960 -0.317
ENSG00000150627 E022 10.7915005 0.0045886511 3.076834e-01 4.499119e-01 4 176137520 176137611 92 + 0.906 1.038 0.492
ENSG00000150627 E023 8.4813616 0.0021055707 5.130076e-01 6.478608e-01 4 176139892 176139974 83 + 0.822 0.914 0.354
ENSG00000150627 E024 9.1048026 0.0037082688 6.920224e-01 7.933477e-01 4 176141983 176142069 87 + 0.873 0.806 -0.258
ENSG00000150627 E025 11.4061731 0.0015544973 3.061966e-01 4.483576e-01 4 176145995 176146159 165 + 0.965 0.807 -0.605
ENSG00000150627 E026 16.5481785 0.0015855794 1.425187e-01 2.514597e-01 4 176148133 176148335 203 + 1.114 0.914 -0.734
ENSG00000150627 E027 15.9970719 0.0011336157 1.693262e-01 2.873064e-01 4 176149807 176149956 150 + 1.102 0.914 -0.691
ENSG00000150627 E028 10.1372859 0.0020649435 3.978645e-02 9.062999e-02 4 176150043 176150173 131 + 0.936 0.569 -1.499
ENSG00000150627 E029 5.7003201 0.0028358509 4.395952e-02 9.830490e-02 4 176150468 176150490 23 + 0.728 0.279 -2.270
ENSG00000150627 E030 9.2878407 0.0050118835 4.137096e-01 5.571201e-01 4 176150491 176150593 103 + 0.880 0.741 -0.544
ENSG00000150627 E031 14.6633851 0.0012434258 1.623453e-01 2.781873e-01 4 176151812 176151967 156 + 1.064 0.864 -0.745
ENSG00000150627 E032 7.9825606 0.0022072829 1.480281e-01 2.589896e-01 4 176156079 176156088 10 + 0.837 0.569 -1.120
ENSG00000150627 E033 9.9203200 0.0017832682 4.765729e-02 1.050098e-01 4 176156089 176156143 55 + 0.924 0.569 -1.453
ENSG00000150627 E034 11.7940118 0.0014219504 4.713881e-02 1.040719e-01 4 176159994 176160126 133 + 0.992 0.663 -1.290
ENSG00000150627 E035 8.2301960 0.0070148650 3.861636e-02 8.847779e-02 4 176160911 176161002 92 + 0.859 0.448 -1.789
ENSG00000150627 E036 8.4033796 0.0022584271 5.413319e-01 6.723378e-01 4 176162075 176162174 100 + 0.845 0.741 -0.412
ENSG00000150627 E037 0.6256415 0.0176870198 4.243791e-01 5.673532e-01 4 176163058 176163153 96 + 0.131 0.279 1.354
ENSG00000150627 E038 12.5338495 0.0215446235 4.370080e-01 5.790391e-01 4 176163154 176163293 140 + 0.965 1.073 0.399
ENSG00000150627 E039 0.0000000       4 176166124 176166144 21 +      
ENSG00000150627 E040 0.0000000       4 176168648 176168671 24 +      
ENSG00000150627 E041 11.6503528 0.0016189894 3.113163e-02 7.415998e-02 4 176168672 176168783 112 + 0.906 1.162 0.940
ENSG00000150627 E042 0.0000000       4 176172331 176172374 44 +      
ENSG00000150627 E043 12.6446424 0.0069069158 8.695988e-01 9.201559e-01 4 176172375 176172516 142 + 0.986 0.960 -0.098
ENSG00000150627 E044 10.8500030 0.0164882978 1.836549e-01 3.057935e-01 4 176173267 176173369 103 + 0.893 1.074 0.675
ENSG00000150627 E045 13.1438928 0.0026419843 3.162610e-03 1.074514e-02 4 176174617 176174718 102 + 0.930 1.259 1.189
ENSG00000150627 E046 10.2978792 0.0018112549 2.040744e-01 3.312707e-01 4 176177058 176177156 99 + 0.873 1.038 0.618
ENSG00000150627 E047 13.7245165 0.0015282406 5.481457e-01 6.780224e-01 4 176177471 176177654 184 + 1.002 1.073 0.258
ENSG00000150627 E048 11.5382184 0.0016203636 8.749604e-01 9.236625e-01 4 176179460 176179632 173 + 0.942 0.960 0.065
ENSG00000150627 E049 51.3652725 0.0004572362 4.105191e-10 6.534332e-09 4 176179633 176182818 3186 + 1.489 1.836 1.180
ENSG00000150627 E050 0.2924217 0.0273037168 1.000000e+00   4 176183495 176183522 28 + 0.092 0.000 -10.646