ENSG00000150625

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000280187 ENSG00000150625 HEK293_OSMI2_2hA HEK293_TMG_2hB GPM6A protein_coding protein_coding 2.635208 1.307617 4.363554 0.4046816 0.105951 1.730875 0.1285543 0.06812088 0.3437371 0.06812088 0.1901451 2.1788973 0.05082500 0.07393333 0.07790000 0.003966667 7.723626e-01 1.064153e-05 FALSE TRUE
ENST00000393658 ENSG00000150625 HEK293_OSMI2_2hA HEK293_TMG_2hB GPM6A protein_coding protein_coding 2.635208 1.307617 4.363554 0.4046816 0.105951 1.730875 0.9421470 0.99208789 1.3875293 0.35492086 0.3833124 0.4798695 0.45813333 0.73923333 0.32150000 -0.417733333 1.715679e-02 1.064153e-05 FALSE TRUE
ENST00000506219 ENSG00000150625 HEK293_OSMI2_2hA HEK293_TMG_2hB GPM6A protein_coding processed_transcript 2.635208 1.307617 4.363554 0.4046816 0.105951 1.730875 0.0711156 0.00000000 0.2287142 0.00000000 0.2287142 4.5772127 0.02774583 0.00000000 0.05083333 0.050833333 1.000000e+00 1.064153e-05   FALSE
ENST00000506894 ENSG00000150625 HEK293_OSMI2_2hA HEK293_TMG_2hB GPM6A protein_coding protein_coding 2.635208 1.307617 4.363554 0.4046816 0.105951 1.730875 1.2651867 0.20867642 2.2688949 0.05466312 0.1671621 3.3814648 0.40943333 0.16856667 0.51870000 0.350133333 1.064153e-05 1.064153e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000150625 E001 0.0000000       4 175632934 175632936 3 -      
ENSG00000150625 E002 25.7946073 0.0008723237 2.820665e-18 1.468040e-16 4 175632937 175633444 508 - 1.148 1.723 1.990
ENSG00000150625 E003 8.5593631 0.0080023540 1.030654e-03 4.064328e-03 4 175633445 175633446 2 - 0.812 1.189 1.396
ENSG00000150625 E004 78.6369053 0.0003432275 2.499562e-03 8.761533e-03 4 175633447 175634545 1099 - 1.832 1.950 0.400
ENSG00000150625 E005 16.0491489 0.0119127871 7.030149e-03 2.130331e-02 4 175634546 175634707 162 - 1.105 1.375 0.953
ENSG00000150625 E006 22.0435051 0.0292661411 6.196141e-01 7.369655e-01 4 175634708 175634919 212 - 1.343 1.293 -0.171
ENSG00000150625 E007 22.1930748 0.0186065713 1.944769e-01 3.193692e-01 4 175634920 175635057 138 - 1.368 1.231 -0.481
ENSG00000150625 E008 11.2028802 0.0127337317 5.136220e-01 6.484126e-01 4 175640129 175640133 5 - 1.078 0.996 -0.302
ENSG00000150625 E009 19.9186760 0.0009829172 2.516019e-01 3.878627e-01 4 175640134 175640194 61 - 1.316 1.221 -0.333
ENSG00000150625 E010 20.9571327 0.0008860827 3.076604e-01 4.498887e-01 4 175640753 175640829 77 - 1.332 1.249 -0.288
ENSG00000150625 E011 0.0000000       4 175640830 175641745 916 -      
ENSG00000150625 E012 0.0000000       4 175642024 175642082 59 -      
ENSG00000150625 E013 0.1515154 0.0482814649 1.000000e+00   4 175651827 175651833 7 - 0.075 0.000 -10.348
ENSG00000150625 E014 15.2093212 0.0012508354 8.482716e-01 9.057759e-01 4 175651834 175651869 36 - 1.171 1.191 0.071
ENSG00000150625 E015 15.3133611 0.0210669509 3.203072e-01 4.634031e-01 4 175651870 175651889 20 - 1.209 1.100 -0.387
ENSG00000150625 E016 16.3336445 0.0104997961 8.117358e-01 8.805343e-01 4 175651890 175651912 23 - 1.214 1.189 -0.088
ENSG00000150625 E017 13.1234747 0.0015167634 3.331870e-01 4.768765e-01 4 175651913 175651917 5 - 1.142 1.044 -0.357
ENSG00000150625 E018 14.4710921 0.0013481997 2.147261e-01 3.441121e-01 4 175651918 175651939 22 - 1.187 1.065 -0.439
ENSG00000150625 E019 14.9808063 0.0013712546 2.467152e-01 3.820896e-01 4 175651940 175651987 48 - 1.198 1.086 -0.403
ENSG00000150625 E020 0.0000000       4 175654216 175654323 108 -      
ENSG00000150625 E021 10.1436500 0.0017845433 3.727683e-02 8.599382e-02 4 175673680 175673691 12 - 1.072 0.819 -0.950
ENSG00000150625 E022 13.6739383 0.0014698747 4.615551e-02 1.023225e-01 4 175673692 175673728 37 - 1.182 0.972 -0.761
ENSG00000150625 E023 14.5281870 0.0013016927 2.005919e-02 5.161218e-02 4 175673729 175673746 18 - 1.213 0.972 -0.872
ENSG00000150625 E024 13.2975411 0.0013508828 5.929196e-02 1.254222e-01 4 175673747 175673753 7 - 1.171 0.972 -0.722
ENSG00000150625 E025 17.6749187 0.0013719594 1.678934e-02 4.447335e-02 4 175673754 175673836 83 - 1.291 1.065 -0.806
ENSG00000150625 E026 8.4585570 0.0020817838 3.487751e-01 4.930005e-01 4 175701575 175701584 10 - 0.970 0.854 -0.439
ENSG00000150625 E027 24.5161781 0.0008351326 2.711086e-02 6.621892e-02 4 175701585 175701767 183 - 1.412 1.236 -0.614
ENSG00000150625 E028 0.2214452 0.1409005926 1.512993e-01   4 175781209 175781297 89 - 0.000 0.194 11.530
ENSG00000150625 E029 0.0000000       4 175786872 175786917 46 -      
ENSG00000150625 E030 0.0000000       4 175787336 175787425 90 -      
ENSG00000150625 E031 0.0000000       4 175787426 175787676 251 -      
ENSG00000150625 E032 0.0000000       4 175787779 175788079 301 -      
ENSG00000150625 E033 0.0000000       4 175807348 175807617 270 -      
ENSG00000150625 E034 2.2334008 0.2907828655 5.760852e-01 7.015784e-01 4 175812191 175812196 6 - 0.516 0.334 -0.978
ENSG00000150625 E035 2.8161679 0.0073110587 1.371492e-01 2.441185e-01 4 175812197 175812249 53 - 0.605 0.326 -1.437
ENSG00000150625 E036 0.1515154 0.0482814649 1.000000e+00   4 175812250 175812264 15 - 0.075 0.000 -10.348
ENSG00000150625 E037 0.0000000       4 175872663 175872730 68 -      
ENSG00000150625 E038 0.0000000       4 175891463 175891690 228 -      
ENSG00000150625 E039 0.0000000       4 175891691 175891754 64 -      
ENSG00000150625 E040 0.4355181 0.6693235405 8.804396e-01 9.273228e-01 4 175906653 175906851 199 - 0.194 0.000 -10.514
ENSG00000150625 E041 0.0000000       4 175907043 175907316 274 -      
ENSG00000150625 E042 0.2934659 0.0274589771 4.189436e-01   4 175947645 175947698 54 - 0.075 0.193 1.559
ENSG00000150625 E043 0.0000000       4 175960744 175960759 16 -      
ENSG00000150625 E044 0.7468662 0.0189371978 4.869579e-01 6.246671e-01 4 175961237 175961341 105 - 0.195 0.325 0.973
ENSG00000150625 E045 0.0000000       4 175970873 175970967 95 -      
ENSG00000150625 E046 0.0000000       4 175971877 175971988 112 -      
ENSG00000150625 E047 12.3191341 0.0015329814 5.506349e-01 6.802398e-01 4 176002309 176002664 356 - 1.105 1.044 -0.223