ENSG00000150556

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000280115 ENSG00000150556 HEK293_OSMI2_2hA HEK293_TMG_2hB LYPD6B protein_coding protein_coding 1.550879 2.140857 1.668282 0.07402529 0.1642873 -0.3579268 0.68382646 1.44219669 0.0000000 0.03370021 0.0000000 -7.182093 0.42031667 0.67596667 0.0000000 -0.6759667 2.035559e-20 2.035559e-20 FALSE TRUE
ENST00000409029 ENSG00000150556 HEK293_OSMI2_2hA HEK293_TMG_2hB LYPD6B protein_coding protein_coding 1.550879 2.140857 1.668282 0.07402529 0.1642873 -0.3579268 0.06347584 0.34133744 0.0000000 0.07522830 0.0000000 -5.134785 0.03780000 0.15756667 0.0000000 -0.1575667 9.154117e-06 2.035559e-20 FALSE TRUE
ENST00000409642 ENSG00000150556 HEK293_OSMI2_2hA HEK293_TMG_2hB LYPD6B protein_coding protein_coding 1.550879 2.140857 1.668282 0.07402529 0.1642873 -0.3579268 0.34106467 0.26212666 0.6575130 0.08065681 0.2222747 1.294518 0.23419167 0.12053333 0.3787000 0.2581667 1.286803e-01 2.035559e-20 FALSE TRUE
ENST00000409876 ENSG00000150556 HEK293_OSMI2_2hA HEK293_TMG_2hB LYPD6B protein_coding protein_coding 1.550879 2.140857 1.668282 0.07402529 0.1642873 -0.3579268 0.32582657 0.09519647 0.8132887 0.09519647 0.1671128 2.968312 0.19917917 0.04596667 0.4821333 0.4361667 1.314395e-02 2.035559e-20 FALSE TRUE
ENST00000442722 ENSG00000150556 HEK293_OSMI2_2hA HEK293_TMG_2hB LYPD6B protein_coding nonsense_mediated_decay 1.550879 2.140857 1.668282 0.07402529 0.1642873 -0.3579268 0.10012876 0.00000000 0.1974801 0.00000000 0.1481755 4.374901 0.07804167 0.00000000 0.1391667 0.1391667 2.752347e-01 2.035559e-20   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000150556 E001 0.0000000       2 149038107 149038134 28 +      
ENSG00000150556 E002 0.6998377 0.018376737 0.7878978939 0.8641402887 2 149038699 149038717 19 + 0.243 0.195 -0.407
ENSG00000150556 E003 3.1292492 0.010338012 0.4152844022 0.5586749187 2 149038718 149038801 84 + 0.677 0.549 -0.560
ENSG00000150556 E004 0.0000000       2 149077520 149077521 2 +      
ENSG00000150556 E005 0.0000000       2 149077522 149077596 75 +      
ENSG00000150556 E006 0.0000000       2 149101100 149101583 484 +      
ENSG00000150556 E007 0.0000000       2 149118174 149118180 7 +      
ENSG00000150556 E008 0.0000000       2 149118181 149118195 15 +      
ENSG00000150556 E009 0.0000000       2 149118196 149118265 70 +      
ENSG00000150556 E010 1.1781284 0.011514687 0.4294640598 0.5721888554 2 149119103 149119163 61 + 0.243 0.382 0.912
ENSG00000150556 E011 4.2113098 0.004059470 0.7577261949 0.8424392702 2 149130883 149130953 71 + 0.740 0.695 -0.188
ENSG00000150556 E012 0.0000000       2 149131268 149131341 74 +      
ENSG00000150556 E013 0.0000000       2 149131342 149131588 247 +      
ENSG00000150556 E014 0.0000000       2 149142036 149142215 180 +      
ENSG00000150556 E015 0.0000000       2 149143854 149143858 5 +      
ENSG00000150556 E016 0.1482932 0.041774808 0.6220808921   2 149143859 149143956 98 + 0.000 0.108 10.148
ENSG00000150556 E017 2.5045276 0.006581363 0.1202253180 0.2203208209 2 149160764 149160835 72 + 0.677 0.430 -1.147
ENSG00000150556 E018 0.0000000       2 149161449 149161477 29 +      
ENSG00000150556 E019 0.5514428 0.020217138 0.1342596832 0.2400760218 2 149187426 149187579 154 + 0.000 0.267 11.607
ENSG00000150556 E020 0.0000000       2 149187580 149187635 56 +      
ENSG00000150556 E021 0.0000000       2 149188658 149188731 74 +      
ENSG00000150556 E022 0.0000000       2 149200626 149200708 83 +      
ENSG00000150556 E023 0.0000000       2 149204525 149204529 5 +      
ENSG00000150556 E024 0.1515154 0.042310019 0.3805728423   2 149204793 149204993 201 + 0.138 0.000 -11.764
ENSG00000150556 E025 0.1472490 0.043585117 0.3800560965   2 149205075 149205143 69 + 0.138 0.000 -11.761
ENSG00000150556 E026 10.3848786 0.016855189 0.0376391034 0.0866533220 2 149205253 149205404 152 + 1.172 0.949 -0.814
ENSG00000150556 E027 1.8276057 0.246685621 0.2468623312 0.3822671532 2 149206019 149206195 177 + 0.600 0.324 -1.427
ENSG00000150556 E028 11.3721920 0.001628447 0.0190344349 0.0494103477 2 149208314 149208412 99 + 1.204 0.989 -0.777
ENSG00000150556 E029 16.5904256 0.001350883 0.4868861214 0.6246004120 2 149212992 149213122 131 + 1.204 1.254 0.175
ENSG00000150556 E030 40.8727247 0.001285143 0.0001949402 0.0009423148 2 149214546 149215262 717 + 1.507 1.667 0.545