ENSG00000150455

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392678 ENSG00000150455 HEK293_OSMI2_2hA HEK293_TMG_2hB TIRAP protein_coding protein_coding 7.19944 9.749437 4.734333 0.1759773 0.09111554 -1.040592 1.6806817 3.1589883 0.4285437 0.31239115 0.14681120 -2.8532297 0.2045958 0.32316667 0.09176667 -0.23140000 0.01066697 0.01066697 FALSE TRUE
ENST00000392679 ENSG00000150455 HEK293_OSMI2_2hA HEK293_TMG_2hB TIRAP protein_coding protein_coding 7.19944 9.749437 4.734333 0.1759773 0.09111554 -1.040592 4.1011329 4.5509028 3.1264656 0.37957496 0.26167421 -0.5401797 0.5940125 0.46766667 0.65993333 0.19226667 0.09439705 0.01066697 FALSE TRUE
MSTRG.6544.1 ENSG00000150455 HEK293_OSMI2_2hA HEK293_TMG_2hB TIRAP protein_coding   7.19944 9.749437 4.734333 0.1759773 0.09111554 -1.040592 0.5355379 0.9022873 0.1583346 0.09284422 0.08466435 -2.4381565 0.0710375 0.09296667 0.03310000 -0.05986667 0.22979912 0.01066697 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000150455 E001 2.8021555 0.0058957554 8.988241e-01 9.394681e-01 11 126283015 126283064 50 + 0.539 0.554 0.070
ENSG00000150455 E002 2.3906872 0.0064362084 7.054992e-01 8.038543e-01 11 126283065 126283072 8 + 0.539 0.468 -0.343
ENSG00000150455 E003 4.8306801 0.0035710282 3.552796e-01 4.996315e-01 11 126283073 126283092 20 + 0.807 0.669 -0.562
ENSG00000150455 E004 5.4155341 0.0043479574 5.978718e-01 7.195724e-01 11 126283093 126283105 13 + 0.807 0.725 -0.327
ENSG00000150455 E005 9.3446103 0.0236966084 9.117177e-01 9.479812e-01 11 126283106 126283109 4 + 0.971 0.947 -0.089
ENSG00000150455 E006 12.8445283 0.0148617515 5.259273e-01 6.592387e-01 11 126283110 126283117 8 + 1.139 1.058 -0.293
ENSG00000150455 E007 23.1507411 0.0064538103 7.726567e-01 8.532643e-01 11 126283118 126283153 36 + 1.315 1.329 0.047
ENSG00000150455 E008 0.6213751 0.0223549684 7.442301e-02 1.506123e-01 11 126288443 126288573 131 + 0.394 0.085 -2.775
ENSG00000150455 E009 8.9875312 0.0322337108 7.799034e-01 8.585146e-01 11 126289665 126289817 153 + 0.971 0.926 -0.167
ENSG00000150455 E010 3.3086461 0.0047219739 3.393035e-01 4.831996e-01 11 126289818 126289833 16 + 0.472 0.626 0.716
ENSG00000150455 E011 39.1718964 0.0015088280 9.516882e-01 9.737331e-01 11 126290462 126290585 124 + 1.555 1.542 -0.045
ENSG00000150455 E012 36.6245189 0.0007339492 7.010497e-02 1.435415e-01 11 126290803 126290855 53 + 1.440 1.547 0.367
ENSG00000150455 E013 39.5287463 0.0007513727 1.388451e-02 3.796461e-02 11 126290856 126290961 106 + 1.448 1.592 0.494
ENSG00000150455 E014 1.0716524 0.0119017106 9.016355e-01 9.413264e-01 11 126291273 126291424 152 + 0.297 0.270 -0.190
ENSG00000150455 E015 5.3829952 0.0226121742 2.305059e-01 3.630644e-01 11 126291425 126291569 145 + 0.897 0.721 -0.691
ENSG00000150455 E016 136.1695979 0.0003491828 1.557665e-02 4.179341e-02 11 126292477 126293055 579 + 2.038 2.102 0.214
ENSG00000150455 E017 20.5256366 0.0048346571 6.596139e-08 6.940013e-07 11 126293056 126293244 189 + 0.807 1.383 2.099
ENSG00000150455 E018 168.5884837 0.0021755804 1.212266e-05 7.900515e-05 11 126293668 126294639 972 + 2.272 2.139 -0.442
ENSG00000150455 E019 20.6057693 0.0022801029 2.282062e-01 3.602850e-01 11 126294640 126294933 294 + 1.364 1.260 -0.364
ENSG00000150455 E020 7.1704631 0.0406139420 9.834105e-01 9.936858e-01 11 126298258 126298845 588 + 0.870 0.851 -0.071