ENSG00000150403

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000434316 ENSG00000150403 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCO3 protein_coding protein_coding 8.513222 4.892344 12.17354 1.034119 0.3380705 1.313389 4.9752661 2.5543249 7.6809131 0.44502701 0.22043547 1.5845758 0.59480833 0.52970000 0.63093333 0.10123333 0.07160474 0.0389041 FALSE TRUE
ENST00000460039 ENSG00000150403 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCO3 protein_coding processed_transcript 8.513222 4.892344 12.17354 1.034119 0.3380705 1.313389 0.1044887 0.2628803 0.0000000 0.13146418 0.00000000 -4.7701963 0.01690833 0.05440000 0.00000000 -0.05440000 0.03890410 0.0389041 FALSE FALSE
ENST00000474393 ENSG00000150403 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCO3 protein_coding protein_coding 8.513222 4.892344 12.17354 1.034119 0.3380705 1.313389 0.5253060 0.4227032 0.5890981 0.07877628 0.11223718 0.4694144 0.07313750 0.09266667 0.04843333 -0.04423333 0.38973758 0.0389041 FALSE TRUE
ENST00000622371 ENSG00000150403 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCO3 protein_coding protein_coding 8.513222 4.892344 12.17354 1.034119 0.3380705 1.313389 0.3792205 0.4038561 0.5476984 0.04445720 0.05820423 0.4303558 0.05391667 0.08580000 0.04523333 -0.04056667 0.13297976 0.0389041 FALSE FALSE
MSTRG.9106.3 ENSG00000150403 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCO3 protein_coding   8.513222 4.892344 12.17354 1.034119 0.3380705 1.313389 1.8385172 0.7030276 2.8662767 0.01573552 0.11182088 2.0121726 0.17606667 0.15616667 0.23603333 0.07986667 0.22893678 0.0389041 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000150403 E001 4.7719162 0.0424659918 4.352416e-01 5.774858e-01 13 113491021 113491042 22 + 0.698 0.816 0.474
ENSG00000150403 E002 11.6214383 0.0462417218 5.332228e-01 6.654466e-01 13 113491043 113491095 53 + 1.053 1.120 0.243
ENSG00000150403 E003 32.6189042 0.0168214366 6.768892e-02 1.395144e-01 13 113491096 113491273 178 + 1.555 1.375 -0.620
ENSG00000150403 E004 90.4345552 0.0006220258 1.409423e-07 1.391890e-06 13 113495502 113495870 369 + 2.001 1.781 -0.742
ENSG00000150403 E005 62.4987318 0.0003877645 8.464866e-05 4.500571e-04 13 113495871 113496025 155 + 1.837 1.646 -0.646
ENSG00000150403 E006 83.1609064 0.0003323508 3.578789e-03 1.195168e-02 13 113498342 113498521 180 + 1.943 1.825 -0.395
ENSG00000150403 E007 0.7321044 0.4062767026 6.943111e-01 7.951732e-01 13 113498522 113498645 124 + 0.212 0.294 0.627
ENSG00000150403 E008 66.2299795 0.0005541611 6.064627e-01 7.266024e-01 13 113499958 113500020 63 + 1.815 1.795 -0.069
ENSG00000150403 E009 40.5703147 0.0069566567 3.420035e-01 4.859888e-01 13 113500021 113500023 3 + 1.619 1.551 -0.231
ENSG00000150403 E010 85.4781307 0.0005390896 5.512023e-01 6.807099e-01 13 113500024 113500149 126 + 1.906 1.932 0.088
ENSG00000150403 E011 72.7317028 0.0004714741 6.135113e-01 7.321810e-01 13 113501752 113501880 129 + 1.839 1.863 0.082
ENSG00000150403 E012 65.4376308 0.0004522692 4.263743e-01 5.692090e-01 13 113503496 113503588 93 + 1.811 1.777 -0.115
ENSG00000150403 E013 31.5254027 0.0006876063 1.908196e-07 1.835687e-06 13 113503589 113506062 2474 + 1.355 1.679 1.111
ENSG00000150403 E014 66.9532048 0.0003666077 8.100470e-01 8.794275e-01 13 113510238 113510424 187 + 1.808 1.822 0.047
ENSG00000150403 E015 0.1482932 0.0411597534 2.005861e-01   13 113520546 113520615 70 + 0.000 0.177 11.506
ENSG00000150403 E016 46.5899160 0.0005288748 1.818247e-01 3.035277e-01 13 113520616 113520733 118 + 1.632 1.706 0.251
ENSG00000150403 E017 50.3515535 0.0006441636 2.455105e-01 3.806499e-01 13 113534045 113534240 196 + 1.669 1.731 0.211
ENSG00000150403 E018 12.2577606 0.0247548939 7.287451e-03 2.196916e-02 13 113534241 113535286 1046 + 0.974 1.280 1.104
ENSG00000150403 E019 45.0163097 0.0004902515 2.484112e-01 3.840503e-01 13 113539357 113539507 151 + 1.619 1.684 0.220
ENSG00000150403 E020 1.5092443 0.1208531292 2.290712e-03 8.121454e-03 13 113545755 113545897 143 + 0.083 0.662 4.093
ENSG00000150403 E021 0.8898489 0.1519952747 9.018024e-01 9.414176e-01 13 113547149 113547299 151 + 0.265 0.299 0.234
ENSG00000150403 E022 29.5309616 0.0007012760 7.479861e-01 8.353744e-01 13 113547300 113547379 80 + 1.456 1.480 0.083
ENSG00000150403 E023 38.4376724 0.0005418534 6.517377e-02 1.353256e-01 13 113548303 113548332 30 + 1.537 1.646 0.371
ENSG00000150403 E024 57.3042034 0.0004588030 3.476439e-01 4.918383e-01 13 113548333 113548452 120 + 1.729 1.777 0.163
ENSG00000150403 E025 42.3452718 0.0047923379 6.729449e-01 7.787534e-01 13 113549425 113549501 77 + 1.626 1.603 -0.077
ENSG00000150403 E026 62.1097934 0.0317351793 6.101179e-01 7.294731e-01 13 113549502 113549633 132 + 1.788 1.763 -0.083
ENSG00000150403 E027 72.7647213 0.0065977795 1.952168e-02 5.046012e-02 13 113549634 113550229 596 + 1.798 1.940 0.477
ENSG00000150403 E028 0.8920389 0.0133392297 8.523739e-01 9.085209e-01 13 113550755 113550815 61 + 0.265 0.302 0.256
ENSG00000150403 E029 0.1482932 0.0411597534 2.005861e-01   13 113551337 113551428 92 + 0.000 0.177 11.506
ENSG00000150403 E030 0.7468662 0.0312762648 6.419155e-01 7.548569e-01 13 113551429 113551562 134 + 0.213 0.302 0.668
ENSG00000150403 E031 0.5117906 0.1996311431 8.339310e-01 8.960017e-01 13 113551563 113552031 469 + 0.152 0.179 0.282
ENSG00000150403 E032 3.2848170 0.0048287904 8.926765e-02 1.740259e-01 13 113552032 113554590 2559 + 0.520 0.780 1.120