ENSG00000150401

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000332592 ENSG00000150401 HEK293_OSMI2_2hA HEK293_TMG_2hB DCUN1D2 protein_coding protein_coding 5.810123 2.752411 7.485063 0.3034226 0.3482734 1.440012 0.06435653 0.3364272 0.08219872 0.26674156 0.08219872 -1.9097336 0.01637917 0.10603333 0.01046667 -0.095566667 4.294435e-01 5.950218e-12 FALSE TRUE
ENST00000465710 ENSG00000150401 HEK293_OSMI2_2hA HEK293_TMG_2hB DCUN1D2 protein_coding protein_coding 5.810123 2.752411 7.485063 0.3034226 0.3482734 1.440012 0.43306122 0.1027060 0.64885647 0.06922036 0.03540908 2.5474005 0.06934583 0.03853333 0.08733333 0.048800000 2.641127e-01 5.950218e-12   FALSE
ENST00000465938 ENSG00000150401 HEK293_OSMI2_2hA HEK293_TMG_2hB DCUN1D2 protein_coding protein_coding 5.810123 2.752411 7.485063 0.3034226 0.3482734 1.440012 1.40811501 0.0000000 1.74509371 0.00000000 0.26082664 7.4554043 0.19894583 0.00000000 0.23080000 0.230800000 5.950218e-12 5.950218e-12 FALSE FALSE
ENST00000478244 ENSG00000150401 HEK293_OSMI2_2hA HEK293_TMG_2hB DCUN1D2 protein_coding protein_coding 5.810123 2.752411 7.485063 0.3034226 0.3482734 1.440012 0.76526470 0.3625233 1.10901924 0.20479842 0.12134960 1.5868323 0.14454583 0.13203333 0.14993333 0.017900000 8.223945e-01 5.950218e-12 FALSE TRUE
MSTRG.9103.1 ENSG00000150401 HEK293_OSMI2_2hA HEK293_TMG_2hB DCUN1D2 protein_coding   5.810123 2.752411 7.485063 0.3034226 0.3482734 1.440012 2.31040836 1.4866153 2.45227030 0.27348859 0.18421691 0.7182857 0.41969167 0.55556667 0.32750000 -0.228066667 3.337276e-01 5.950218e-12 TRUE TRUE
MSTRG.9103.5 ENSG00000150401 HEK293_OSMI2_2hA HEK293_TMG_2hB DCUN1D2 protein_coding   5.810123 2.752411 7.485063 0.3034226 0.3482734 1.440012 0.27727854 0.1622823 0.44806307 0.08456517 0.22968436 1.4107721 0.05346667 0.05963333 0.06116667 0.001533333 1.000000e+00 5.950218e-12 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000150401 E001 0.4427912 0.1847417804 1.000000e+00 1.000000e+00 13 113455815 113455818 4 - 0.158 0.170 0.127
ENSG00000150401 E002 150.2745436 0.0108909434 1.275119e-06 1.035482e-05 13 113455819 113457796 1978 - 2.052 2.312 0.870
ENSG00000150401 E003 8.4273580 0.0055322746 4.027443e-01 5.465288e-01 13 113457797 113457798 2 - 0.970 0.917 -0.198
ENSG00000150401 E004 43.4011406 0.0027288212 6.168899e-01 7.348336e-01 13 113457799 113458108 310 - 1.621 1.644 0.077
ENSG00000150401 E005 28.9055039 0.0007538486 7.782040e-01 8.572862e-01 13 113459312 113459408 97 - 1.443 1.477 0.118
ENSG00000150401 E006 0.4783925 0.0211618811 1.000000e+00 1.000000e+00 13 113459409 113459543 135 - 0.158 0.171 0.142
ENSG00000150401 E007 12.9902848 0.0013090007 7.896635e-01 8.654066e-01 13 113461054 113461054 1 - 1.101 1.177 0.271
ENSG00000150401 E008 23.6282671 0.0009110251 3.241278e-01 4.674953e-01 13 113461055 113461136 82 - 1.384 1.366 -0.064
ENSG00000150401 E009 19.6639718 0.0010136257 1.505898e-01 2.624818e-01 13 113462740 113462891 152 - 1.316 1.253 -0.221
ENSG00000150401 E010 0.7511326 0.5472637491 8.198545e-01 8.862861e-01 13 113462892 113463088 197 - 0.221 0.284 0.476
ENSG00000150401 E011 21.0884056 0.0062801275 6.700632e-01 7.766427e-01 13 113474124 113474196 73 - 1.288 1.376 0.307
ENSG00000150401 E012 13.5334593 0.0113885914 7.800238e-01 8.585823e-01 13 113474197 113474209 13 - 1.130 1.150 0.071
ENSG00000150401 E013 16.9842409 0.0304891361 3.653202e-01 5.096500e-01 13 113474210 113474254 45 - 1.251 1.195 -0.201
ENSG00000150401 E014 0.3268771 0.0316049870 6.224927e-01   13 113480466 113480574 109 - 0.086 0.171 1.142
ENSG00000150401 E015 23.5669564 0.0106445774 6.844977e-02 1.408038e-01 13 113480575 113480647 73 - 1.403 1.290 -0.396
ENSG00000150401 E016 22.4003199 0.0008777347 1.918131e-02 4.973185e-02 13 113480648 113480743 96 - 1.392 1.265 -0.444
ENSG00000150401 E017 15.4950079 0.0011689272 5.215170e-02 1.129903e-01 13 113483840 113483901 62 - 1.241 1.117 -0.444
ENSG00000150401 E018 16.2473116 0.0012083874 1.071992e-01 2.013921e-01 13 113483902 113483962 61 - 1.252 1.162 -0.319
ENSG00000150401 E019 17.1373508 0.0010617966 1.533231e-02 4.124240e-02 13 113483963 113484056 94 - 1.293 1.132 -0.568
ENSG00000150401 E020 12.6921965 0.0014602286 8.556561e-03 2.518081e-02 13 113484057 113484196 140 - 1.183 0.965 -0.794
ENSG00000150401 E021 3.9451068 0.0044187431 1.003447e-01 1.910035e-01 13 113489090 113489173 84 - 0.748 0.533 -0.930
ENSG00000150401 E022 4.2459476 0.0039154947 6.017759e-02 1.269115e-01 13 113489174 113489253 80 - 0.781 0.533 -1.061
ENSG00000150401 E023 1.9103121 0.0092592412 2.134383e-03 7.640823e-03 13 113490433 113490666 234 - 0.585 0.000 -11.963
ENSG00000150401 E024 5.2694045 0.0032782391 2.272126e-03 8.065720e-03 13 113490667 113490951 285 - 0.892 0.467 -1.813