ENSG00000150093

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000302278 ENSG00000150093 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGB1 protein_coding protein_coding 35.54685 8.327612 62.36384 0.3665126 1.248105 2.903235 22.35888 7.81264 36.83772 0.407631 1.6332945 2.235848 0.7612083 0.9375333 0.5904333 -0.3471000 2.424793e-19 1.093036e-47 FALSE TRUE
MSTRG.3766.25 ENSG00000150093 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGB1 protein_coding   35.54685 8.327612 62.36384 0.3665126 1.248105 2.903235 11.49752 0.00000 21.96215 0.000000 0.9434715 11.101460 0.1857667 0.0000000 0.3521333 0.3521333 1.093036e-47 1.093036e-47 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000150093 E001 0.1515154 0.0428301669 6.906022e-01   10 32887273 32887331 59 - 0.046 0.000 -8.216
ENSG00000150093 E002 13.2589581 0.0013755559 1.750780e-09 2.480036e-08 10 32887332 32889002 1671 - 0.835 1.467 2.280
ENSG00000150093 E003 1.2168277 0.0107160203 9.013743e-01 9.411418e-01 10 32900277 32900317 41 - 0.252 0.289 0.266
ENSG00000150093 E004 0.9264823 0.0792594912 6.711180e-01 7.774324e-01 10 32900318 32900318 1 - 0.194 0.289 0.751
ENSG00000150093 E005 1.3692735 0.1772555665 3.672501e-01 5.116317e-01 10 32900319 32900332 14 - 0.252 0.459 1.253
ENSG00000150093 E006 5.7624545 0.0028273658 7.538268e-03 2.261301e-02 10 32900333 32900411 79 - 0.605 1.019 1.640
ENSG00000150093 E007 4.8736498 0.0032576754 6.557526e-03 2.007439e-02 10 32900412 32900413 2 - 0.540 0.978 1.784
ENSG00000150093 E008 5.0251652 0.0031764031 8.346192e-03 2.465710e-02 10 32900414 32900425 12 - 0.554 0.978 1.719
ENSG00000150093 E009 145.9459107 0.0235129069 1.067085e-05 7.046128e-05 10 32900426 32901254 829 - 1.919 2.306 1.294
ENSG00000150093 E010 75.6530052 0.0045832998 2.627294e-14 8.123601e-13 10 32901255 32901511 257 - 1.620 2.072 1.524
ENSG00000150093 E011 46.3358480 0.0162242915 9.940561e-07 8.251367e-06 10 32901512 32901563 52 - 1.418 1.850 1.471
ENSG00000150093 E012 64.4386388 0.0007747803 9.073338e-08 9.281909e-07 10 32901564 32901635 72 - 1.584 1.905 1.087
ENSG00000150093 E013 1.0498971 0.3680152653 3.109851e-01 4.534344e-01 10 32906010 32906318 309 - 0.194 0.451 1.691
ENSG00000150093 E014 1.1962157 0.2357087832 8.543225e-01 9.098881e-01 10 32906319 32906464 146 - 0.253 0.286 0.241
ENSG00000150093 E015 1.1813402 0.0107308934 9.017746e-01 9.414093e-01 10 32906465 32906562 98 - 0.252 0.289 0.265
ENSG00000150093 E016 0.1515154 0.0428301669 6.906022e-01   10 32906563 32906580 18 - 0.046 0.000 -10.157
ENSG00000150093 E017 0.8815316 0.0136968632 5.828002e-01 7.070704e-01 10 32906581 32907062 482 - 0.223 0.000 -13.080
ENSG00000150093 E018 0.1515154 0.0428301669 6.906022e-01   10 32907063 32907143 81 - 0.046 0.000 -10.157
ENSG00000150093 E019 1.0340911 0.0115890712 7.859177e-01 8.628989e-01 10 32907144 32908367 1224 - 0.224 0.289 0.487
ENSG00000150093 E020 58.6202702 0.0010132184 5.808956e-03 1.811088e-02 10 32908368 32908534 167 - 1.568 1.761 0.655
ENSG00000150093 E021 55.2735133 0.0004349654 9.882127e-02 1.886777e-01 10 32910223 32910455 233 - 1.556 1.683 0.432
ENSG00000150093 E022 101.1644597 0.0003176870 4.982461e-01 6.347325e-01 10 32911448 32911526 79 - 1.834 1.814 -0.068
ENSG00000150093 E023 246.0003044 0.0002315886 4.231057e-01 5.662181e-01 10 32911527 32911670 144 - 2.210 2.254 0.146
ENSG00000150093 E024 406.7992306 0.0001561551 4.661208e-02 1.031398e-01 10 32911886 32912124 239 - 2.424 2.491 0.225
ENSG00000150093 E025 331.0361444 0.0001530355 1.946224e-01 3.195306e-01 10 32919885 32920084 200 - 2.336 2.390 0.179
ENSG00000150093 E026 318.6398882 0.0050038142 5.819826e-01 7.064313e-01 10 32920245 32920385 141 - 2.328 2.321 -0.023
ENSG00000150093 E027 0.7415557 0.1336776148 5.505263e-01 6.801411e-01 10 32920386 32920397 12 - 0.161 0.287 1.061
ENSG00000150093 E028 2.5139683 0.2013269064 8.978827e-01 9.388105e-01 10 32920398 32921570 1173 - 0.428 0.455 0.136
ENSG00000150093 E029 0.8147077 0.1522896739 5.411481e-01 6.721800e-01 10 32921571 32921702 132 - 0.161 0.291 1.088
ENSG00000150093 E030 1.4694955 0.0121213129 9.471084e-01 9.707854e-01 10 32921703 32922256 554 - 0.303 0.289 -0.098
ENSG00000150093 E031 247.6411670 0.0008212766 3.045789e-01 4.465962e-01 10 32922257 32922346 90 - 2.221 2.200 -0.070
ENSG00000150093 E032 232.8319937 0.0027035081 3.152040e-01 4.579505e-01 10 32922640 32922735 96 - 2.195 2.168 -0.092
ENSG00000150093 E033 0.2966881 0.0290785164 1.000000e+00   10 32922778 32923584 807 - 0.088 0.000 -11.297
ENSG00000150093 E034 283.9958990 0.0002016759 7.569123e-01 8.418884e-01 10 32923585 32923740 156 - 2.276 2.283 0.023
ENSG00000150093 E035 199.7184130 0.0025801890 5.170649e-01 6.515354e-01 10 32925871 32925960 90 - 2.125 2.113 -0.039
ENSG00000150093 E036 260.8892981 0.0012437874 7.787182e-02 1.560575e-01 10 32925961 32926109 149 - 2.245 2.196 -0.166
ENSG00000150093 E037 173.3831017 0.0002268947 4.091267e-02 9.272406e-02 10 32928094 32928149 56 - 2.071 2.001 -0.238
ENSG00000150093 E038 187.8147699 0.0004497896 6.432300e-02 1.339025e-01 10 32928150 32928211 62 - 2.104 2.044 -0.202
ENSG00000150093 E039 174.7717085 0.0002049187 1.896138e-02 4.924830e-02 10 32928212 32928264 53 - 2.076 1.992 -0.282
ENSG00000150093 E040 137.4432282 0.0002466353 2.119243e-02 5.400359e-02 10 32929822 32929840 19 - 1.974 1.878 -0.322
ENSG00000150093 E041 164.0355618 0.0002573136 1.513450e-03 5.679621e-03 10 32929841 32929884 44 - 2.053 1.925 -0.430
ENSG00000150093 E042 140.9733697 0.0002248932 1.046777e-02 2.990305e-02 10 32929885 32929931 47 - 1.986 1.878 -0.361
ENSG00000150093 E043 131.0073996 0.0002303498 2.704687e-03 9.387958e-03 10 32929932 32929984 53 - 1.957 1.821 -0.460
ENSG00000150093 E044 130.5896074 0.0002330440 1.271144e-02 3.523410e-02 10 32929985 32930032 48 - 1.953 1.845 -0.366
ENSG00000150093 E045 102.0314598 0.0003355691 2.883127e-02 6.966921e-02 10 32930033 32930044 12 - 1.847 1.739 -0.365
ENSG00000150093 E046 0.0000000       10 32932506 32932510 5 -      
ENSG00000150093 E047 0.0000000       10 32932511 32932514 4 -      
ENSG00000150093 E048 94.1520166 0.0003030211 5.764629e-02 1.225871e-01 10 32932515 32932520 6 - 1.811 1.716 -0.321
ENSG00000150093 E049 151.0612988 0.0002389679 9.849889e-04 3.907675e-03 10 32932521 32932590 70 - 2.019 1.878 -0.473
ENSG00000150093 E050 82.2746132 0.0003597603 1.261396e-03 4.847804e-03 10 32932591 32932600 10 - 1.765 1.567 -0.673
ENSG00000150093 E051 0.0000000       10 32932601 32933350 750 -      
ENSG00000150093 E052 3.2934170 0.0054323223 2.830244e-01 4.230995e-01 10 32933351 32933481 131 - 0.526 0.289 -1.319
ENSG00000150093 E053 3.2843326 0.2765670533 1.289015e-01 2.326295e-01 10 32933482 32933583 102 - 0.542 0.000 -13.823
ENSG00000150093 E054 113.6598789 0.0002881560 5.405063e-03 1.702819e-02 10 32935492 32935558 67 - 1.897 1.761 -0.459
ENSG00000150093 E055 0.6966286 0.4470316505 3.249055e-02 7.678689e-02 10 32935895 32936081 187 - 0.046 0.587 4.668
ENSG00000150093 E056 1.1383756 0.4362314247 1.595418e-01 2.745107e-01 10 32936217 32936241 25 - 0.161 0.587 2.671
ENSG00000150093 E057 0.7686241 0.1279240438 5.441851e-01 6.746917e-01 10 32936242 32936349 108 - 0.161 0.289 1.077
ENSG00000150093 E058 0.7728905 0.0143264352 5.393516e-01 6.706317e-01 10 32936350 32936423 74 - 0.161 0.289 1.073
ENSG00000150093 E059 0.1515154 0.0428301669 6.906022e-01   10 32938554 32938730 177 - 0.046 0.000 -10.157
ENSG00000150093 E060 0.2966881 0.0290785164 1.000000e+00   10 32951675 32951758 84 - 0.088 0.000 -11.297
ENSG00000150093 E061 2.3939014 0.0061066000 8.513028e-01 9.077985e-01 10 32953593 32953809 217 - 0.410 0.461 0.265
ENSG00000150093 E062 0.1472490 0.0432793115 6.905122e-01   10 32954459 32954490 32 - 0.046 0.000 -10.152
ENSG00000150093 E063 0.0000000       10 32955570 32955663 94 -      
ENSG00000150093 E064 0.8867284 0.0157163091 6.675562e-01 7.747684e-01 10 32957011 32957225 215 - 0.193 0.289 0.750
ENSG00000150093 E065 0.9630009 0.0750091108 1.585362e-01 2.731674e-01 10 32957226 32957758 533 - 0.161 0.461 2.074
ENSG00000150093 E066 4.6155352 0.1110079548 9.583743e-01 9.779175e-01 10 32957759 32958144 386 - 0.605 0.589 -0.073
ENSG00000150093 E067 70.8895974 0.0006418784 5.814035e-03 1.812313e-02 10 32958145 32958325 181 - 1.700 1.520 -0.614
ENSG00000150093 E068 0.1515154 0.0428301669 6.906022e-01   10 32958486 32958886 401 - 0.046 0.000 -10.157
ENSG00000150093 E069 0.0000000       10 32960290 32960324 35 -      
ENSG00000150093 E070 0.0000000       10 32960325 32960366 42 -      
ENSG00000150093 E071 0.0000000       10 32960367 32960503 137 -      
ENSG00000150093 E072 0.0000000       10 32961108 32961160 53 -      
ENSG00000150093 E073 0.0000000       10 32963181 32963283 103 -      
ENSG00000150093 E074 0.0000000       10 32992331 32992463 133 -      
ENSG00000150093 E075 0.1817044 0.0396769231 3.904823e-02   10 33005615 33005792 178 - 0.000 0.289 13.137