ENSG00000150054

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375732 ENSG00000150054 HEK293_OSMI2_2hA HEK293_TMG_2hB MPP7 protein_coding protein_coding 2.028958 0.7484224 3.023911 0.09832955 0.1416017 2.000106 0.08776459 0.22079727 0.0000000 0.11588477 0.00000000 -4.528554 0.1301083 0.3362333 0.0000000 -0.3362333 0.09711368 0.03216801 FALSE TRUE
ENST00000683449 ENSG00000150054 HEK293_OSMI2_2hA HEK293_TMG_2hB MPP7 protein_coding protein_coding 2.028958 0.7484224 3.023911 0.09832955 0.1416017 2.000106 1.33002777 0.09948106 2.0889710 0.09948106 0.06267522 4.260929 0.5080417 0.1239333 0.6922333 0.5683000 0.03216801 0.03216801 FALSE TRUE
MSTRG.3702.7 ENSG00000150054 HEK293_OSMI2_2hA HEK293_TMG_2hB MPP7 protein_coding   2.028958 0.7484224 3.023911 0.09832955 0.1416017 2.000106 0.49418697 0.42814405 0.9349405 0.13521028 0.09681151 1.108818 0.3305208 0.5398333 0.3077667 -0.2320667 0.08893517 0.03216801 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000150054 E001 1.261676 0.016432593 6.483986e-04 2.710381e-03 10 28050993 28051167 175 - 0.118 0.704 3.705
ENSG00000150054 E002 86.258258 0.011365272 1.688137e-01 2.866401e-01 10 28051168 28054060 2893 - 1.874 1.790 -0.286
ENSG00000150054 E003 7.633239 0.002256749 4.776363e-01 6.161555e-01 10 28054061 28054142 82 - 0.840 0.928 0.337
ENSG00000150054 E004 6.755862 0.002455134 9.651014e-01 9.820402e-01 10 28054143 28054244 102 - 0.820 0.809 -0.045
ENSG00000150054 E005 10.794708 0.004940985 5.617240e-01 6.894719e-01 10 28056480 28056623 144 - 1.008 0.929 -0.296
ENSG00000150054 E006 9.258492 0.002103109 2.891282e-01 4.298060e-01 10 28058495 28058603 109 - 0.959 0.809 -0.574
ENSG00000150054 E007 0.000000       10 28059516 28059649 134 -      
ENSG00000150054 E008 7.786595 0.022555987 1.014857e-01 1.927300e-01 10 28059650 28059743 94 - 0.920 0.643 -1.109
ENSG00000150054 E009 9.435807 0.020480604 2.975407e-02 7.147518e-02 10 28069772 28069852 81 - 1.001 0.643 -1.410
ENSG00000150054 E010 10.472190 0.001863341 1.725324e-03 6.362546e-03 10 28089671 28089841 171 - 1.052 0.570 -1.919
ENSG00000150054 E011 5.051954 0.003848312 1.249571e-05 8.120456e-05 10 28118857 28119061 205 - 0.523 1.098 2.304
ENSG00000150054 E012 10.392637 0.001683512 1.572484e-01 2.714372e-01 10 28119651 28119715 65 - 0.944 1.099 0.569
ENSG00000150054 E013 6.933310 0.002366241 3.310770e-02 7.802448e-02 10 28120194 28120207 14 - 0.754 1.022 1.026
ENSG00000150054 E014 14.522578 0.002045757 2.924476e-03 1.004320e-02 10 28120208 28120390 183 - 1.040 1.316 0.983
ENSG00000150054 E015 12.686684 0.055305562 3.563582e-01 5.007413e-01 10 28120594 28120668 75 - 1.028 1.163 0.489
ENSG00000150054 E016 12.482616 0.008794909 1.824056e-01 3.042427e-01 10 28124031 28124071 41 - 1.021 1.164 0.516
ENSG00000150054 E017 12.303816 0.001544457 4.565099e-02 1.013933e-01 10 28124072 28124116 45 - 1.002 1.203 0.726
ENSG00000150054 E018 14.401804 0.001235196 4.911173e-01 6.284197e-01 10 28125010 28125091 82 - 1.129 1.049 -0.290
ENSG00000150054 E019 16.827002 0.001087134 1.581242e-01 2.726136e-01 10 28131560 28131691 132 - 1.203 1.049 -0.553
ENSG00000150054 E020 13.954795 0.001350883 9.732522e-02 1.863984e-01 10 28147483 28147563 81 - 1.129 0.928 -0.737
ENSG00000150054 E021 12.895747 0.001516763 9.327538e-01 9.616249e-01 10 28149982 28150059 78 - 1.064 1.049 -0.055
ENSG00000150054 E022 11.507471 0.001711187 6.821388e-01 7.856449e-01 10 28202153 28202271 119 - 1.008 1.049 0.150
ENSG00000150054 E023 0.000000       10 28202893 28203232 340 -      
ENSG00000150054 E024 0.000000       10 28236601 28236939 339 -      
ENSG00000150054 E025 11.044674 0.001703013 4.421013e-01 5.837504e-01 10 28238568 28238735 168 - 1.028 0.928 -0.370
ENSG00000150054 E026 0.000000       10 28238736 28238737 2 -      
ENSG00000150054 E027 0.000000       10 28254774 28254876 103 -      
ENSG00000150054 E028 0.000000       10 28280100 28280140 41 -      
ENSG00000150054 E029 0.000000       10 28280141 28280142 2 -      
ENSG00000150054 E030 0.000000       10 28282010 28282138 129 -      
ENSG00000150054 E031 4.861887 0.076250713 3.804485e-01 5.247302e-01 10 28302861 28303064 204 - 0.741 0.565 -0.753
ENSG00000150054 E032 0.000000       10 28329929 28330002 74 -      
ENSG00000150054 E033 0.000000       10 28334418 28334486 69 -