ENSG00000149930

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000279394 ENSG00000149930 HEK293_OSMI2_2hA HEK293_TMG_2hB TAOK2 protein_coding protein_coding 62.8858 89.28195 42.79566 5.332348 0.8120128 -1.060728 17.705507 28.480871 12.3178368 1.0562180 0.3213277 -1.20858007 0.27507500 0.31993333 0.28800000 -0.03193333 3.537682e-01 3.412013e-12 FALSE TRUE
ENST00000308893 ENSG00000149930 HEK293_OSMI2_2hA HEK293_TMG_2hB TAOK2 protein_coding protein_coding 62.8858 89.28195 42.79566 5.332348 0.8120128 -1.060728 29.841475 37.333801 22.7677125 4.7909642 0.7322142 -0.71324590 0.49318750 0.41456667 0.53196667 0.11740000 6.094150e-02 3.412013e-12 FALSE TRUE
ENST00000566552 ENSG00000149930 HEK293_OSMI2_2hA HEK293_TMG_2hB TAOK2 protein_coding retained_intron 62.8858 89.28195 42.79566 5.332348 0.8120128 -1.060728 6.575891 15.909108 0.5467115 1.8673647 0.1273285 -4.83768584 0.08254167 0.18183333 0.01273333 -0.16910000 3.412013e-12 3.412013e-12 FALSE TRUE
ENST00000570844 ENSG00000149930 HEK293_OSMI2_2hA HEK293_TMG_2hB TAOK2 protein_coding retained_intron 62.8858 89.28195 42.79566 5.332348 0.8120128 -1.060728 4.122003 3.149529 2.9652698 0.3826096 0.3023084 -0.08668885 0.06875417 0.03506667 0.06926667 0.03420000 1.554819e-03 3.412013e-12 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000149930 E001 11.198586 4.193443e-03 1.527437e-01 2.653952e-01 16 29973868 29973882 15 + 1.142 1.009 -0.482
ENSG00000149930 E002 13.342939 9.137550e-03 3.205508e-02 7.596336e-02 16 29973883 29973886 4 + 1.255 1.055 -0.717
ENSG00000149930 E003 40.028984 1.915644e-02 1.311910e-03 5.017006e-03 16 29973887 29973898 12 + 1.743 1.477 -0.905
ENSG00000149930 E004 311.869577 4.246610e-03 8.505485e-06 5.742885e-05 16 29973899 29974181 283 + 2.550 2.404 -0.486
ENSG00000149930 E005 273.083842 7.406405e-03 4.222380e-04 1.859494e-03 16 29974182 29974280 99 + 2.491 2.348 -0.474
ENSG00000149930 E006 573.469587 4.319262e-03 4.501694e-04 1.967318e-03 16 29974281 29974648 368 + 2.783 2.686 -0.324
ENSG00000149930 E007 472.892220 1.449976e-03 9.123096e-07 7.638748e-06 16 29977738 29977904 167 + 2.702 2.600 -0.339
ENSG00000149930 E008 374.267371 7.971752e-04 3.362737e-08 3.751608e-07 16 29978089 29978160 72 + 2.605 2.495 -0.366
ENSG00000149930 E009 453.667405 6.798048e-04 2.398275e-09 3.313975e-08 16 29978252 29978353 102 + 2.687 2.579 -0.360
ENSG00000149930 E010 288.972608 5.790268e-04 2.914167e-06 2.186456e-05 16 29978799 29978844 46 + 2.484 2.387 -0.324
ENSG00000149930 E011 438.816803 3.378367e-04 1.467713e-10 2.518831e-09 16 29978974 29979070 97 + 2.671 2.563 -0.358
ENSG00000149930 E012 535.120177 1.204113e-04 2.614689e-15 9.369111e-14 16 29979195 29979308 114 + 2.762 2.649 -0.378
ENSG00000149930 E013 484.318886 1.417951e-03 1.033057e-05 6.845864e-05 16 29979417 29979508 92 + 2.705 2.616 -0.296
ENSG00000149930 E014 27.689938 2.118931e-02 2.177877e-11 4.293812e-10 16 29980352 29981660 1309 + 1.750 1.126 -2.157
ENSG00000149930 E015 441.522945 1.739726e-04 4.135002e-06 2.996686e-05 16 29981661 29981754 94 + 2.650 2.581 -0.229
ENSG00000149930 E016 398.091093 1.259839e-04 2.279158e-05 1.394232e-04 16 29981859 29981940 82 + 2.601 2.537 -0.216
ENSG00000149930 E017 634.682087 3.146793e-04 2.670609e-01 4.053413e-01 16 29982734 29982901 168 + 2.760 2.758 -0.005
ENSG00000149930 E018 826.440368 1.905777e-03 2.051882e-01 3.326455e-01 16 29983072 29983332 261 + 2.839 2.889 0.169
ENSG00000149930 E019 653.439384 1.369330e-04 6.269684e-02 1.311963e-01 16 29983503 29983664 162 + 2.737 2.783 0.153
ENSG00000149930 E020 8.099489 2.084893e-03 1.394267e-01 2.472478e-01 16 29985118 29985212 95 + 1.027 0.872 -0.580
ENSG00000149930 E021 1052.001771 7.846604e-05 3.798747e-07 3.440557e-06 16 29985213 29985578 366 + 2.920 2.999 0.264
ENSG00000149930 E022 579.374706 1.067863e-03 3.788517e-08 4.182292e-07 16 29985658 29985861 204 + 2.611 2.757 0.485
ENSG00000149930 E023 694.791408 7.801492e-04 3.085803e-08 3.463247e-07 16 29986265 29986504 240 + 2.704 2.833 0.431
ENSG00000149930 E024 738.784471 1.779840e-04 1.035902e-03 4.082474e-03 16 29986505 29986843 339 + 2.777 2.844 0.224
ENSG00000149930 E025 1871.341063 2.002856e-03 3.316993e-20 2.166877e-18 16 29986844 29988358 1515 + 3.063 3.285 0.739
ENSG00000149930 E026 69.825234 3.692726e-04 4.682390e-01 6.076576e-01 16 29988359 29988450 92 + 1.815 1.798 -0.058
ENSG00000149930 E027 57.567423 2.944731e-03 5.284410e-08 5.668510e-07 16 29989195 29989274 80 + 1.898 1.626 -0.919
ENSG00000149930 E028 400.893914 1.967657e-04 7.822476e-01 8.601954e-01 16 29989593 29989805 213 + 2.544 2.566 0.074
ENSG00000149930 E029 73.341231 7.500703e-04 2.636497e-21 1.955663e-19 16 29989910 29990542 633 + 2.061 1.671 -1.311
ENSG00000149930 E030 61.366684 1.738456e-02 1.727122e-03 6.368199e-03 16 29990543 29990647 105 + 1.899 1.670 -0.772
ENSG00000149930 E031 36.970866 2.109559e-02 1.482248e-03 5.579770e-03 16 29990648 29990783 136 + 1.705 1.436 -0.918
ENSG00000149930 E032 357.676710 1.660085e-04 1.447603e-04 7.243446e-04 16 29990784 29990966 183 + 2.437 2.535 0.327
ENSG00000149930 E033 843.943882 2.791374e-03 1.814550e-09 2.561175e-08 16 29991047 29992261 1215 + 2.741 2.934 0.641