ENSG00000149923

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000279387 ENSG00000149923 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP4C protein_coding protein_coding 265.8891 460.6195 170.4573 15.57106 2.219383 -1.434112 160.83020 283.01948 99.38629 11.211982 3.9039306 -1.50968846 0.59641667 0.61460000 0.5827333 -0.03186667 6.378126e-01 7.5026e-17 FALSE  
ENST00000563732 ENSG00000149923 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP4C protein_coding nonsense_mediated_decay 265.8891 460.6195 170.4573 15.57106 2.219383 -1.434112 13.67274 22.07593 23.20237 10.574151 0.7747572 0.07176632 0.05649583 0.04650000 0.1363000 0.08980000 3.394234e-01 7.5026e-17 FALSE  
ENST00000627746 ENSG00000149923 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP4C protein_coding protein_coding 265.8891 460.6195 170.4573 15.57106 2.219383 -1.434112 15.56790 28.66005 0.00000 8.438622 0.0000000 -11.48532882 0.05622917 0.06336667 0.0000000 -0.06336667 7.502600e-17 7.5026e-17 FALSE  
MSTRG.12423.1 ENSG00000149923 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP4C protein_coding   265.8891 460.6195 170.4573 15.57106 2.219383 -1.434112 32.14245 62.42649 19.73270 4.921789 3.0957848 -1.66107025 0.11672917 0.13556667 0.1158333 -0.01973333 7.286689e-01 7.5026e-17 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000149923 E001 1.332764 1.152993e-02 9.564213e-01 9.767032e-01 16 30075978 30075983 6 + 0.330 0.326 -0.024
ENSG00000149923 E002 3.060234 5.080860e-03 3.876917e-01 5.318356e-01 16 30075984 30075986 3 + 0.644 0.510 -0.607
ENSG00000149923 E003 12.308798 1.405134e-03 3.076885e-05 1.825862e-04 16 30075987 30075993 7 + 1.320 0.927 -1.415
ENSG00000149923 E004 33.926135 7.119445e-03 6.451078e-02 1.342315e-01 16 30075994 30075999 6 + 1.552 1.421 -0.450
ENSG00000149923 E005 34.447490 6.302639e-03 3.006263e-02 7.207657e-02 16 30076000 30076000 1 + 1.572 1.421 -0.519
ENSG00000149923 E006 48.475383 3.649695e-03 6.485325e-03 1.988488e-02 16 30076001 30076004 4 + 1.722 1.564 -0.537
ENSG00000149923 E007 51.461612 4.337368e-03 1.027701e-03 4.054286e-03 16 30076005 30076006 2 + 1.770 1.580 -0.647
ENSG00000149923 E008 148.308329 9.787952e-03 1.281958e-04 6.509330e-04 16 30076007 30076016 10 + 2.235 2.032 -0.679
ENSG00000149923 E009 153.921211 1.208493e-02 2.526443e-04 1.186394e-03 16 30076017 30076017 1 + 2.255 2.048 -0.694
ENSG00000149923 E010 193.354979 1.203807e-02 1.093083e-03 4.280486e-03 16 30076018 30076022 5 + 2.333 2.155 -0.592
ENSG00000149923 E011 204.135354 1.162606e-02 2.198345e-04 1.048884e-03 16 30076023 30076023 1 + 2.371 2.173 -0.663
ENSG00000149923 E012 327.531636 8.932253e-03 5.486476e-03 1.725168e-02 16 30076024 30076028 5 + 2.522 2.399 -0.410
ENSG00000149923 E013 376.292871 5.719962e-03 1.581868e-03 5.899796e-03 16 30076029 30076031 3 + 2.577 2.461 -0.387
ENSG00000149923 E014 1140.975053 2.428053e-03 5.256688e-03 1.662877e-02 16 30076032 30076094 63 + 2.898 2.988 0.301
ENSG00000149923 E015 189.889118 1.209550e-03 1.803334e-04 8.794856e-04 16 30076095 30076100 6 + 2.070 2.220 0.503
ENSG00000149923 E016 5.750859 3.139500e-03 6.350036e-03 1.953295e-02 16 30076101 30076224 124 + 1.004 0.657 -1.359
ENSG00000149923 E017 11.344963 4.974524e-03 9.255818e-03 2.692329e-02 16 30076225 30076314 90 + 1.198 0.928 -0.982
ENSG00000149923 E018 992.263601 2.032369e-03 1.084939e-05 7.150407e-05 16 30076315 30076317 3 + 2.805 2.934 0.429
ENSG00000149923 E019 2197.949336 9.547894e-04 6.847024e-01 7.876302e-01 16 30076318 30076475 158 + 3.238 3.259 0.071
ENSG00000149923 E020 38.084281 1.196528e-02 6.724037e-02 1.387680e-01 16 30081200 30081258 59 + 1.611 1.474 -0.467
ENSG00000149923 E021 1523.457037 3.030183e-04 1.973251e-01 3.228904e-01 16 30081259 30081310 52 + 3.099 3.095 -0.012
ENSG00000149923 E022 7.754088 2.215395e-03 3.412863e-02 8.001543e-02 16 30081311 30081689 379 + 1.050 0.806 -0.920
ENSG00000149923 E023 1587.273452 1.566089e-04 4.721799e-04 2.053746e-03 16 30082484 30082534 51 + 3.135 3.107 -0.092
ENSG00000149923 E024 2191.289276 5.050037e-05 2.128916e-02 5.419581e-02 16 30082746 30082847 102 + 3.259 3.250 -0.027
ENSG00000149923 E025 61.349785 2.009457e-02 1.225684e-06 9.988759e-06 16 30082848 30082963 116 + 1.974 1.590 -1.298
ENSG00000149923 E026 157.533423 8.941597e-03 4.453293e-11 8.334121e-10 16 30082964 30083393 430 + 2.356 2.012 -1.152
ENSG00000149923 E027 3456.228978 6.726775e-05 1.663424e-02 4.413157e-02 16 30083394 30083567 174 + 3.454 3.449 -0.016
ENSG00000149923 E028 42.947320 1.687806e-02 1.203415e-04 6.155389e-04 16 30083568 30083654 87 + 1.775 1.467 -1.046
ENSG00000149923 E029 3393.253197 3.405127e-04 4.505742e-01 5.916597e-01 16 30083655 30083781 127 + 3.439 3.445 0.022
ENSG00000149923 E030 2.430431 6.237962e-03 3.665782e-03 1.219826e-02 16 30083782 30083805 24 + 0.786 0.326 -2.192
ENSG00000149923 E031 3836.648095 8.372333e-04 1.151030e-02 3.237317e-02 16 30084666 30084855 190 + 3.457 3.508 0.167
ENSG00000149923 E032 3510.774531 1.547781e-03 2.708960e-07 2.528599e-06 16 30084933 30085376 444 + 3.369 3.480 0.369