ENSG00000149782

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000279230 ENSG00000149782 HEK293_OSMI2_2hA HEK293_TMG_2hB PLCB3 protein_coding protein_coding 17.31947 23.6524 11.45669 0.8968701 0.3260494 -1.045147 14.4021433 19.2611955 9.5031453 3.10106084 0.3089616 -1.018452 0.83155000 0.80790000 0.82996667 0.02206667 0.951389381 0.004620106 FALSE  
ENST00000325234 ENSG00000149782 HEK293_OSMI2_2hA HEK293_TMG_2hB PLCB3 protein_coding protein_coding 17.31947 23.6524 11.45669 0.8968701 0.3260494 -1.045147 0.5742664 2.3499973 0.0000000 2.34999728 0.0000000 -7.882641 0.02520000 0.10513333 0.00000000 -0.10513333 0.909189983 0.004620106 FALSE  
ENST00000536243 ENSG00000149782 HEK293_OSMI2_2hA HEK293_TMG_2hB PLCB3 protein_coding retained_intron 17.31947 23.6524 11.45669 0.8968701 0.3260494 -1.045147 1.0860728 0.3532317 0.9050443 0.08845939 0.2497133 1.332951 0.06975417 0.01523333 0.07893333 0.06370000 0.004620106 0.004620106    
ENST00000540288 ENSG00000149782 HEK293_OSMI2_2hA HEK293_TMG_2hB PLCB3 protein_coding protein_coding 17.31947 23.6524 11.45669 0.8968701 0.3260494 -1.045147 1.2569876 1.6879761 1.0485043 0.17572568 0.1189042 -0.681789 0.07350417 0.07170000 0.09106667 0.01936667 0.552645633 0.004620106 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000149782 E001 5.341939 0.0463804672 5.079145e-05 2.857568e-04 11 64251530 64251546 17 + 1.127 0.484 -2.595
ENSG00000149782 E002 11.048948 0.0015806295 6.390902e-16 2.477465e-14 11 64251547 64251574 28 + 1.460 0.653 -2.994
ENSG00000149782 E003 43.912338 0.0075587393 8.054710e-09 1.010022e-07 11 64251575 64251748 174 + 1.842 1.447 -1.344
ENSG00000149782 E004 66.602824 0.0064949292 1.839774e-07 1.775546e-06 11 64254415 64254492 78 + 1.972 1.660 -1.052
ENSG00000149782 E005 89.272154 0.0082932938 1.993448e-04 9.610462e-04 11 64254748 64254816 69 + 2.046 1.822 -0.755
ENSG00000149782 E006 86.673842 0.0045901149 3.015914e-06 2.255293e-05 11 64254898 64254951 54 + 2.046 1.801 -0.823
ENSG00000149782 E007 119.755145 0.0022999570 6.650849e-07 5.738675e-06 11 64254952 64255038 87 + 2.162 1.952 -0.703
ENSG00000149782 E008 113.385175 0.0002788614 1.435626e-05 9.196736e-05 11 64255234 64255313 80 + 2.108 1.945 -0.546
ENSG00000149782 E009 103.914468 0.0002952610 9.179973e-04 3.677716e-03 11 64255396 64255449 54 + 2.052 1.920 -0.444
ENSG00000149782 E010 110.710053 0.0002938237 2.589691e-04 1.212518e-03 11 64255541 64255616 76 + 2.083 1.942 -0.473
ENSG00000149782 E011 118.736022 0.0003467761 4.868634e-03 1.556417e-02 11 64255721 64255821 101 + 2.089 1.980 -0.366
ENSG00000149782 E012 158.901517 0.0031750998 3.449436e-02 8.070311e-02 11 64256376 64256542 167 + 2.206 2.113 -0.312
ENSG00000149782 E013 135.626179 0.0021470255 1.598627e-02 4.269956e-02 11 64256618 64256764 147 + 2.145 2.042 -0.345
ENSG00000149782 E014 185.784283 0.0036184396 7.893876e-04 3.221263e-03 11 64258473 64258713 241 + 2.304 2.165 -0.465
ENSG00000149782 E015 114.608775 0.0060822621 1.837868e-03 6.720428e-03 11 64258885 64258969 85 + 2.115 1.949 -0.558
ENSG00000149782 E016 159.082633 0.0091085263 5.593886e-01 6.874987e-01 11 64259058 64259244 187 + 2.166 2.128 -0.125
ENSG00000149782 E017 189.709795 0.0002481286 7.901584e-01 8.657918e-01 11 64260029 64260234 206 + 2.224 2.207 -0.055
ENSG00000149782 E018 155.260588 0.0002189335 5.014560e-01 6.376093e-01 11 64261400 64261496 97 + 2.150 2.120 -0.101
ENSG00000149782 E019 136.525781 0.0025939656 1.831024e-01 3.050880e-01 11 64261581 64261665 85 + 2.038 2.085 0.156
ENSG00000149782 E020 158.636752 0.0006621146 5.598433e-01 6.879281e-01 11 64261952 64262076 125 + 2.130 2.141 0.036
ENSG00000149782 E021 172.115399 0.0002626745 6.920165e-01 7.933461e-01 11 64262407 64262561 155 + 2.188 2.167 -0.069
ENSG00000149782 E022 191.171295 0.0046518655 8.398998e-01 9.000219e-01 11 64262647 64262808 162 + 2.230 2.215 -0.051
ENSG00000149782 E023 5.844977 0.0075484100 1.034576e-02 2.961804e-02 11 64263380 64263497 118 + 1.012 0.672 -1.328
ENSG00000149782 E024 157.175119 0.0002411069 6.250648e-02 1.308616e-01 11 64263498 64263597 100 + 2.094 2.146 0.174
ENSG00000149782 E025 147.556214 0.0003007848 7.449534e-02 1.507307e-01 11 64263691 64263795 105 + 2.068 2.120 0.173
ENSG00000149782 E026 100.717029 0.0003682137 8.149782e-02 1.618999e-01 11 64264021 64264112 92 + 1.897 1.959 0.210
ENSG00000149782 E027 80.674237 0.0003586697 2.970220e-04 1.367800e-03 11 64264951 64265104 154 + 1.716 1.879 0.549
ENSG00000149782 E028 43.998558 0.0005142384 7.330872e-04 3.018369e-03 11 64265192 64265227 36 + 1.419 1.629 0.717
ENSG00000149782 E029 158.974266 0.0002148144 1.554638e-04 7.714025e-04 11 64265310 64265502 193 + 2.048 2.165 0.389
ENSG00000149782 E030 246.188279 0.0013199956 7.874800e-03 2.346536e-02 11 64265886 64266039 154 + 2.272 2.347 0.249
ENSG00000149782 E031 198.135602 0.0013971900 2.708870e-01 4.095439e-01 11 64266126 64266202 77 + 2.213 2.243 0.098
ENSG00000149782 E032 234.423253 0.0003407290 3.790721e-04 1.693728e-03 11 64266315 64266404 90 + 2.237 2.327 0.300
ENSG00000149782 E033 179.697829 0.0002664455 6.524026e-07 5.639005e-06 11 64266495 64266552 58 + 2.076 2.225 0.500
ENSG00000149782 E034 200.457396 0.0002379998 5.515556e-12 1.197188e-10 11 64267185 64267271 87 + 2.078 2.281 0.680
ENSG00000149782 E035 242.848244 0.0002480891 5.262002e-21 3.799049e-19 11 64267353 64267570 218 + 2.110 2.373 0.878
ENSG00000149782 E036 195.375321 0.0061882654 1.099893e-07 1.108948e-06 11 64267571 64267923 353 + 2.022 2.281 0.868
ENSG00000149782 E037 33.386212 0.0019252306 9.036975e-01 9.427258e-01 11 64268504 64269150 647 + 1.490 1.473 -0.057