ENSG00000149716

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000279147 ENSG00000149716 HEK293_OSMI2_2hA HEK293_TMG_2hB LTO1 protein_coding protein_coding 25.74176 31.76311 20.70263 1.261829 0.6875884 -0.6172958 7.597911 9.5449057 6.8198320 0.10693621 0.20275852 -0.4843915 0.29741667 0.30133333 0.33020000 0.02886667 6.337090e-01 4.979892e-05 FALSE  
ENST00000537272 ENSG00000149716 HEK293_OSMI2_2hA HEK293_TMG_2hB LTO1 protein_coding protein_coding 25.74176 31.76311 20.70263 1.261829 0.6875884 -0.6172958 2.030381 3.8176720 0.8968302 0.42419650 0.30035336 -2.0775628 0.07354167 0.11953333 0.04350000 -0.07603333 1.789018e-02 4.979892e-05    
ENST00000539414 ENSG00000149716 HEK293_OSMI2_2hA HEK293_TMG_2hB LTO1 protein_coding protein_coding 25.74176 31.76311 20.70263 1.261829 0.6875884 -0.6172958 1.795375 1.3783618 1.5617030 0.36080141 0.05065406 0.1789451 0.07063750 0.04286667 0.07573333 0.03286667 1.653460e-01 4.979892e-05 FALSE  
ENST00000542341 ENSG00000149716 HEK293_OSMI2_2hA HEK293_TMG_2hB LTO1 protein_coding protein_coding 25.74176 31.76311 20.70263 1.261829 0.6875884 -0.6172958 6.492375 9.6071005 3.7069805 0.96303913 0.52083905 -1.3714709 0.24681667 0.30370000 0.17836667 -0.12533333 5.443694e-02 4.979892e-05 FALSE  
ENST00000543023 ENSG00000149716 HEK293_OSMI2_2hA HEK293_TMG_2hB LTO1 protein_coding retained_intron 25.74176 31.76311 20.70263 1.261829 0.6875884 -0.6172958 1.021025 0.5161787 1.5101759 0.16888734 0.38164180 1.5306135 0.04251250 0.01613333 0.07210000 0.05596667 2.369375e-03 4.979892e-05 TRUE  
ENST00000544096 ENSG00000149716 HEK293_OSMI2_2hA HEK293_TMG_2hB LTO1 protein_coding retained_intron 25.74176 31.76311 20.70263 1.261829 0.6875884 -0.6172958 1.766664 1.1120850 1.7844063 0.05469333 0.11174352 0.6773246 0.07130417 0.03513333 0.08670000 0.05156667 4.979892e-05 4.979892e-05    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000149716 E001 4.2006850 0.0038835902 3.863562e-01 5.305477e-01 11 69653076 69653172 97 - 0.619 0.745 0.528
ENSG00000149716 E002 8.1433906 0.0024560942 5.613322e-02 1.199376e-01 11 69653173 69653316 144 - 0.788 1.016 0.869
ENSG00000149716 E003 4.4543955 0.0035613176 1.525433e-01 2.651370e-01 11 69653317 69653319 3 - 0.576 0.785 0.882
ENSG00000149716 E004 0.1451727 0.0432941708 3.416691e-01   11 69654135 69654140 6 - 0.145 0.000 -9.092
ENSG00000149716 E005 0.6696487 0.0253868029 1.701503e-01 2.883820e-01 11 69654141 69654157 17 - 0.340 0.103 -2.142
ENSG00000149716 E006 10.9209700 0.0019008781 1.550424e-01 2.684659e-01 11 69654158 69654384 227 - 0.949 1.098 0.546
ENSG00000149716 E007 3.6212288 0.0048940700 5.037401e-01 6.396973e-01 11 69654385 69654410 26 - 0.576 0.677 0.442
ENSG00000149716 E008 3.6515300 0.0277524243 6.538914e-02 1.356910e-01 11 69656600 69656652 53 - 0.412 0.726 1.452
ENSG00000149716 E009 30.9104195 0.0269252840 1.536579e-01 2.666486e-01 11 69656653 69658430 1778 - 1.563 1.429 -0.462
ENSG00000149716 E010 1.3253775 0.0099542756 8.627049e-01 9.154602e-01 11 69665563 69665565 3 - 0.339 0.369 0.178
ENSG00000149716 E011 14.3474560 0.0275296636 2.532279e-01 3.897256e-01 11 69665566 69665648 83 - 1.067 1.204 0.493
ENSG00000149716 E012 196.0897543 0.0016800352 5.663063e-06 3.981778e-05 11 69665649 69666061 413 - 2.179 2.324 0.482
ENSG00000149716 E013 83.5258700 0.0042270527 8.760090e-03 2.568481e-02 11 69666062 69666184 123 - 1.815 1.948 0.445
ENSG00000149716 E014 31.8256047 0.0007399675 7.723454e-01 8.530404e-01 11 69666185 69666190 6 - 1.486 1.503 0.058
ENSG00000149716 E015 125.6675045 0.0003758823 1.573246e-02 4.213283e-02 11 69666191 69666409 219 - 2.032 2.110 0.262
ENSG00000149716 E016 141.6263731 0.0003833169 7.606888e-01 8.447009e-01 11 69666410 69666666 257 - 2.133 2.141 0.027
ENSG00000149716 E017 82.6700550 0.0003888890 8.597321e-01 9.135323e-01 11 69666667 69666804 138 - 1.901 1.906 0.019
ENSG00000149716 E018 40.1738246 0.0005653904 7.925684e-01 8.673659e-01 11 69666805 69666839 35 - 1.590 1.604 0.045
ENSG00000149716 E019 42.5147207 0.0011489240 1.022417e-01 1.939246e-01 11 69666840 69666888 49 - 1.558 1.650 0.314
ENSG00000149716 E020 65.8715985 0.0004222915 3.069355e-01 4.491130e-01 11 69666889 69667041 153 - 1.780 1.824 0.148
ENSG00000149716 E021 86.9406149 0.0004500252 8.336205e-01 8.957901e-01 11 69667042 69667263 222 - 1.932 1.922 -0.034
ENSG00000149716 E022 76.2116262 0.0003939164 2.590924e-02 6.375988e-02 11 69667264 69667407 144 - 1.928 1.836 -0.310
ENSG00000149716 E023 56.2906287 0.0004730985 5.158745e-03 1.636074e-02 11 69667408 69667444 37 - 1.821 1.688 -0.450
ENSG00000149716 E024 66.5054673 0.0042860844 1.826769e-03 6.686035e-03 11 69667445 69667476 32 - 1.909 1.743 -0.562
ENSG00000149716 E025 56.6229314 0.0096085624 1.149364e-02 3.233455e-02 11 69667477 69667478 2 - 1.841 1.672 -0.572
ENSG00000149716 E026 75.8061482 0.0091108873 5.244888e-02 1.135199e-01 11 69667479 69667493 15 - 1.940 1.819 -0.406
ENSG00000149716 E027 74.3608646 0.0051646044 6.290894e-02 1.315588e-01 11 69667494 69667505 12 - 1.920 1.819 -0.341
ENSG00000149716 E028 66.3513278 0.0028686086 2.093268e-02 5.344663e-02 11 69667506 69667510 5 - 1.879 1.761 -0.396
ENSG00000149716 E029 89.3703519 0.0022138079 1.182392e-02 3.311147e-02 11 69667511 69667587 77 - 2.002 1.892 -0.372
ENSG00000149716 E030 2.9644861 0.0057457225 3.968758e-03 1.305465e-02 11 69667588 69667608 21 - 0.815 0.369 -2.045
ENSG00000149716 E031 23.0872570 0.0130489445 4.426061e-01 5.842012e-01 11 69667609 69667894 286 - 1.407 1.340 -0.232
ENSG00000149716 E032 115.9143646 0.0003147550 9.594698e-02 1.843066e-01 11 69667895 69668012 118 - 2.083 2.026 -0.192
ENSG00000149716 E033 8.5175894 0.0020180172 5.152763e-01 6.499625e-01 11 69668178 69668398 221 - 1.004 0.930 -0.275
ENSG00000149716 E034 7.5614153 0.0084491637 3.153060e-03 1.071650e-02 11 69671143 69671216 74 - 0.619 1.017 1.573
ENSG00000149716 E035 76.1139604 0.0122688673 5.832916e-05 3.232211e-04 11 69671378 69671748 371 - 1.674 1.954 0.944
ENSG00000149716 E036 139.6485198 0.0017301342 1.560219e-02 4.185128e-02 11 69671749 69671819 71 - 2.076 2.162 0.287
ENSG00000149716 E037 48.2226870 0.0008350876 3.074277e-09 4.161575e-08 11 69671820 69672869 1050 - 1.846 1.544 -1.023
ENSG00000149716 E038 18.5990059 0.0010254042 7.604636e-05 4.092828e-04 11 69672870 69673215 346 - 1.451 1.142 -1.083
ENSG00000149716 E039 82.7299485 0.0036673757 8.266382e-03 2.445755e-02 11 69673216 69673221 6 - 1.821 1.951 0.439
ENSG00000149716 E040 167.8448418 0.0003486140 7.681553e-03 2.298013e-02 11 69673222 69673321 100 - 2.163 2.237 0.249
ENSG00000149716 E041 10.7310461 0.0016780299 6.093217e-03 1.885563e-02 11 69673322 69673384 63 - 1.204 0.930 -0.999
ENSG00000149716 E042 15.3124021 0.1087927757 2.106203e-03 7.553076e-03 11 69674551 69674766 216 - 1.445 0.925 -1.856
ENSG00000149716 E043 13.9607133 0.0288183794 1.552347e-06 1.236597e-05 11 69674767 69675189 423 - 1.433 0.843 -2.129
ENSG00000149716 E044 123.8722301 0.0002830828 6.137324e-02 1.289436e-01 11 69675190 69675416 227 - 2.041 2.101 0.199