ENSG00000149679

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000279101 ENSG00000149679 HEK293_OSMI2_2hA HEK293_TMG_2hB CABLES2 protein_coding protein_coding 12.2204 16.00302 11.38313 0.7521615 0.6257032 -0.4910815 8.610324 13.082461 5.754791 0.7870328 1.8837211 -1.183396 0.6969792 0.8258667 0.5275000 -0.2983667 6.469317e-01 2.466175e-08 FALSE TRUE
ENST00000453274 ENSG00000149679 HEK293_OSMI2_2hA HEK293_TMG_2hB CABLES2 protein_coding protein_coding 12.2204 16.00302 11.38313 0.7521615 0.6257032 -0.4910815 1.256418 0.000000 2.261838 0.0000000 0.8065132 7.827716 0.1140208 0.0000000 0.1918000 0.1918000 2.466175e-08 2.466175e-08 FALSE FALSE
MSTRG.20953.1 ENSG00000149679 HEK293_OSMI2_2hA HEK293_TMG_2hB CABLES2 protein_coding   12.2204 16.00302 11.38313 0.7521615 0.6257032 -0.4910815 2.353657 2.920556 3.366497 1.5157186 1.7633096 0.204353 0.1889958 0.1741333 0.2806667 0.1065333 9.398109e-01 2.466175e-08 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000149679 E001 1.705712 0.0987349306 0.778239836 0.85730103 20 62388596 62388621 26 - 0.357 0.438 0.453
ENSG00000149679 E002 20.636551 0.0372948742 0.042811914 0.09619961 20 62388634 62388728 95 - 1.095 1.390 1.040
ENSG00000149679 E003 913.857468 0.0065905659 0.001173785 0.00455238 20 62388729 62391013 2285 - 2.852 2.969 0.389
ENSG00000149679 E004 98.693557 0.0003219305 0.427471276 0.57032396 20 62391014 62391111 98 - 1.927 1.990 0.212
ENSG00000149679 E005 160.144586 0.0003037401 0.826363895 0.89073649 20 62391249 62391453 205 - 2.157 2.184 0.091
ENSG00000149679 E006 148.488360 0.0061762521 0.158199867 0.27271932 20 62392389 62392495 107 - 2.165 2.134 -0.104
ENSG00000149679 E007 157.269574 0.0041429112 0.002925579 0.01004608 20 62392920 62393023 104 - 2.223 2.138 -0.283
ENSG00000149679 E008 161.225202 0.0002399413 0.031230709 0.07434831 20 62393440 62393605 166 - 2.196 2.168 -0.094
ENSG00000149679 E009 117.920321 0.0008958071 0.165837572 0.28278770 20 62394157 62394265 109 - 2.053 2.038 -0.052
ENSG00000149679 E010 78.657621 0.0022386829 0.116769785 0.21534861 20 62394937 62395014 78 - 1.893 1.855 -0.128
ENSG00000149679 E011 79.062735 0.0125855331 0.119799698 0.21969385 20 62396315 62396407 93 - 1.912 1.850 -0.207
ENSG00000149679 E012 52.301315 0.0236869590 0.147171766 0.25783742 20 62396521 62396592 72 - 1.749 1.667 -0.278
ENSG00000149679 E013 37.983451 0.0236820879 0.001391384 0.00527844 20 62406915 62407288 374 - 1.708 1.458 -0.852