ENSG00000149636

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373734 ENSG00000149636 HEK293_OSMI2_2hA HEK293_TMG_2hB DSN1 protein_coding protein_coding 21.48989 12.15519 29.88711 1.564356 0.8208583 1.297247 2.5635793 2.123793 2.353162 0.4704245 0.2209155 0.1472981 0.12951667 0.17243333 0.07926667 -0.093166667 1.054274e-02 4.651362e-34 FALSE TRUE
ENST00000373750 ENSG00000149636 HEK293_OSMI2_2hA HEK293_TMG_2hB DSN1 protein_coding protein_coding 21.48989 12.15519 29.88711 1.564356 0.8208583 1.297247 9.5832399 5.680030 14.525186 1.0264770 0.2999389 1.3530414 0.43815417 0.46450000 0.48720000 0.022700000 9.120759e-01 4.651362e-34 FALSE TRUE
ENST00000426836 ENSG00000149636 HEK293_OSMI2_2hA HEK293_TMG_2hB DSN1 protein_coding protein_coding 21.48989 12.15519 29.88711 1.564356 0.8208583 1.297247 0.8513184 1.659043 0.000000 0.2136270 0.0000000 -7.3828776 0.07466667 0.13713333 0.00000000 -0.137133333 4.651362e-34 4.651362e-34 FALSE TRUE
ENST00000447406 ENSG00000149636 HEK293_OSMI2_2hA HEK293_TMG_2hB DSN1 protein_coding protein_coding 21.48989 12.15519 29.88711 1.564356 0.8208583 1.297247 2.7950494 0.000000 4.864831 0.0000000 0.4191253 8.9292084 0.08839583 0.00000000 0.16376667 0.163766667 8.973937e-22 4.651362e-34 FALSE FALSE
ENST00000448110 ENSG00000149636 HEK293_OSMI2_2hA HEK293_TMG_2hB DSN1 protein_coding protein_coding 21.48989 12.15519 29.88711 1.564356 0.8208583 1.297247 2.1599806 1.506595 2.992761 0.3361541 0.7073617 0.9854540 0.09552083 0.12906667 0.09916667 -0.029900000 7.958502e-01 4.651362e-34 FALSE TRUE
ENST00000480153 ENSG00000149636 HEK293_OSMI2_2hA HEK293_TMG_2hB DSN1 protein_coding retained_intron 21.48989 12.15519 29.88711 1.564356 0.8208583 1.297247 2.1973763 0.918877 2.338656 0.1468967 0.3390308 1.3382758 0.11830833 0.07503333 0.07840000 0.003366667 9.721735e-01 4.651362e-34 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000149636 E001 0.00000       20 36751791 36751794 4 -      
ENSG00000149636 E002 290.06752 0.0011716622 3.258987e-19 1.903223e-17 20 36751795 36752445 651 - 2.351 2.587 0.786
ENSG00000149636 E003 352.44099 0.0016480453 1.524308e-08 1.816659e-07 20 36752446 36752897 452 - 2.472 2.629 0.525
ENSG00000149636 E004 134.30278 0.0065077429 6.681720e-02 1.380887e-01 20 36754763 36754850 88 - 2.074 2.189 0.385
ENSG00000149636 E005 156.55771 0.0002414318 6.641400e-01 7.720062e-01 20 36755682 36755829 148 - 2.172 2.203 0.102
ENSG00000149636 E006 126.18373 0.0003478273 2.073332e-02 5.302408e-02 20 36758087 36758161 75 - 2.113 2.054 -0.197
ENSG00000149636 E007 113.47086 0.0031998090 3.038415e-02 7.271679e-02 20 36758558 36758617 60 - 2.074 1.992 -0.273
ENSG00000149636 E008 121.15868 0.0002957982 2.739128e-04 1.273641e-03 20 36762461 36762548 88 - 2.110 2.004 -0.356
ENSG00000149636 E009 116.22358 0.0003957762 1.638979e-03 6.086199e-03 20 36766769 36766841 73 - 2.087 1.994 -0.311
ENSG00000149636 E010 115.33028 0.0036176448 1.804722e-01 3.017778e-01 20 36767969 36768042 74 - 2.068 2.021 -0.159
ENSG00000149636 E011 133.01836 0.0009349522 5.239033e-02 1.134165e-01 20 36770873 36770974 102 - 2.132 2.083 -0.166
ENSG00000149636 E012 75.86283 0.0006375969 6.187628e-02 1.297760e-01 20 36770975 36770977 3 - 1.894 1.830 -0.215
ENSG00000149636 E013 95.97774 0.0003502462 5.871245e-04 2.486119e-03 20 36770978 36771024 47 - 2.012 1.897 -0.385
ENSG00000149636 E014 117.19164 0.0002657362 4.809978e-04 2.087358e-03 20 36771025 36771114 90 - 2.094 1.992 -0.342
ENSG00000149636 E015 100.82821 0.0003496619 1.491117e-02 4.028632e-02 20 36771115 36771193 79 - 2.020 1.948 -0.242
ENSG00000149636 E016 17.37773 0.0011224501 5.393529e-01 6.706317e-01 20 36771194 36771424 231 - 1.264 1.229 -0.122
ENSG00000149636 E017 74.51939 0.0003446454 2.782666e-04 1.291275e-03 20 36771425 36771473 49 - 1.913 1.772 -0.473
ENSG00000149636 E018 40.24747 0.0093398627 4.046719e-02 9.187686e-02 20 36773394 36773661 268 - 1.647 1.505 -0.485
ENSG00000149636 E019 69.50955 0.0045824191 3.100635e-04 1.420502e-03 20 36773662 36773818 157 - 1.893 1.702 -0.644