ENSG00000149564

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000278927 ENSG00000149564 HEK293_OSMI2_2hA HEK293_TMG_2hB ESAM protein_coding protein_coding 1.856927 2.682309 1.237482 0.1792297 0.1096645 -1.109826 0.49397481 0.8104739 0.5440700 0.406013310 0.2820634 -0.5663892 0.2724125 0.3233667 0.4169333 0.09356667 0.94336203 0.01995873 FALSE TRUE
ENST00000417453 ENSG00000149564 HEK293_OSMI2_2hA HEK293_TMG_2hB ESAM protein_coding nonsense_mediated_decay 1.856927 2.682309 1.237482 0.1792297 0.1096645 -1.109826 0.45620163 0.6397737 0.3335958 0.256527809 0.2105752 -0.9192251 0.2440458 0.2305333 0.2908000 0.06026667 1.00000000 0.01995873 TRUE TRUE
ENST00000444566 ENSG00000149564 HEK293_OSMI2_2hA HEK293_TMG_2hB ESAM protein_coding protein_coding 1.856927 2.682309 1.237482 0.1792297 0.1096645 -1.109826 0.09039449 0.2770830 0.0000000 0.124559270 0.0000000 -4.8433960 0.0416500 0.1083000 0.0000000 -0.10830000 0.01995873 0.01995873 FALSE FALSE
ENST00000464067 ENSG00000149564 HEK293_OSMI2_2hA HEK293_TMG_2hB ESAM protein_coding retained_intron 1.856927 2.682309 1.237482 0.1792297 0.1096645 -1.109826 0.22658022 0.0892901 0.1719730 0.002805003 0.1202087 0.8740030 0.1231375 0.0337000 0.1252000 0.09150000 0.60652836 0.01995873 FALSE TRUE
ENST00000485116 ENSG00000149564 HEK293_OSMI2_2hA HEK293_TMG_2hB ESAM protein_coding retained_intron 1.856927 2.682309 1.237482 0.1792297 0.1096645 -1.109826 0.22688133 0.5254432 0.1878428 0.155195108 0.1042212 -1.4363793 0.1215958 0.1920000 0.1671000 -0.02490000 0.87035104 0.01995873 FALSE TRUE
MSTRG.6500.2 ENSG00000149564 HEK293_OSMI2_2hA HEK293_TMG_2hB ESAM protein_coding   1.856927 2.682309 1.237482 0.1792297 0.1096645 -1.109826 0.34575503 0.3402453 0.0000000 0.340245315 0.0000000 -5.1302938 0.1878750 0.1120667 0.0000000 -0.11206667 0.90579051 0.01995873 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000149564 E001 0.1451727 0.045380260 0.23662852   11 124752583 124752686 104 - 0.164 0.000 -10.107
ENSG00000149564 E002 0.0000000       11 124753089 124753122 34 -      
ENSG00000149564 E003 0.1482932 0.041897700 1.00000000   11 124753123 124753125 3 - 0.000 0.090 10.041
ENSG00000149564 E004 2.1787913 0.008075473 0.21751055 0.34738426 11 124753126 124753198 73 - 0.283 0.519 1.328
ENSG00000149564 E005 53.0477259 0.013233762 0.03148405 0.07485037 11 124753199 124753961 763 - 1.582 1.732 0.507
ENSG00000149564 E006 9.5879927 0.002146932 0.61882913 0.73637503 11 124754214 124754244 31 - 1.008 0.969 -0.147
ENSG00000149564 E007 15.0209326 0.001368642 0.24910050 0.38485530 11 124754245 124754340 96 - 1.221 1.136 -0.301
ENSG00000149564 E008 3.1460585 0.006634266 0.94103942 0.96692140 11 124754630 124754640 11 - 0.575 0.576 0.006
ENSG00000149564 E009 19.1165095 0.001203144 0.85585937 0.91087323 11 124754641 124754763 123 - 1.233 1.263 0.105
ENSG00000149564 E010 14.7112163 0.001516763 0.56619597 0.69320733 11 124756207 124756362 156 - 1.097 1.165 0.245
ENSG00000149564 E011 1.6553499 0.010248257 0.26301018 0.40086962 11 124756363 124756540 178 - 0.518 0.333 -0.995
ENSG00000149564 E012 14.5263543 0.005974430 0.51155259 0.64655483 11 124756541 124756742 202 - 1.170 1.123 -0.167
ENSG00000149564 E013 10.8300109 0.002653736 0.44979496 0.59099826 11 124756743 124757537 795 - 1.063 1.000 -0.231
ENSG00000149564 E014 7.8154730 0.002410563 0.25644218 0.39340059 11 124758349 124758527 179 - 0.988 0.872 -0.436
ENSG00000149564 E015 4.6037380 0.007349723 0.08572397 0.16855195 11 124762085 124762290 206 - 0.871 0.648 -0.899
ENSG00000149564 E016 2.9183724 0.006230779 0.21648146 0.34617262 11 124765818 124765910 93 - 0.670 0.488 -0.824