ENSG00000149547

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000278903 ENSG00000149547 HEK293_OSMI2_2hA HEK293_TMG_2hB EI24 protein_coding protein_coding 253.5699 336.5733 192.0951 21.97372 3.59733 -0.8090679 191.263383 268.295308 132.45578 20.389975 1.4393055 -1.0182559 0.74991250 0.7969333 0.6898667 -0.1070667 0.06414332 1.101186e-23 FALSE  
ENST00000527842 ENSG00000149547 HEK293_OSMI2_2hA HEK293_TMG_2hB EI24 protein_coding protein_coding 253.5699 336.5733 192.0951 21.97372 3.59733 -0.8090679 9.907428 2.795516 14.09776 2.795516 0.5418791 2.3301512 0.04569167 0.0077000 0.0735000 0.0658000 0.04735632 1.101186e-23 FALSE  
MSTRG.6527.4 ENSG00000149547 HEK293_OSMI2_2hA HEK293_TMG_2hB EI24 protein_coding   253.5699 336.5733 192.0951 21.97372 3.59733 -0.8090679 15.637380 9.217967 17.88201 5.821826 1.5833305 0.9552304 0.06403750 0.0271000 0.0932000 0.0661000 0.54338567 1.101186e-23 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000149547 E001 0.4418608 2.586303e-02 2.149047e-02 5.462566e-02 11 125569280 125569332 53 + 0.369 0.000 -14.258
ENSG00000149547 E002 0.5870335 1.236253e-01 1.137123e-02 3.205104e-02 11 125569333 125569365 33 + 0.445 0.000 -14.689
ENSG00000149547 E003 0.7322062 2.599143e-01 1.243587e-02 3.458427e-02 11 125569366 125569372 7 + 0.509 0.000 -15.009
ENSG00000149547 E004 1.1740670 3.200091e-01 4.526817e-03 1.461846e-02 11 125569373 125569396 24 + 0.659 0.000 -15.686
ENSG00000149547 E005 2.6875828 2.173038e-02 2.099241e-07 2.004289e-06 11 125569397 125569403 7 + 0.934 0.092 -5.003
ENSG00000149547 E006 21.9831711 1.772228e-01 2.219435e-06 1.709139e-05 11 125569404 125569445 42 + 1.747 0.782 -3.443
ENSG00000149547 E007 51.1525550 9.619435e-02 7.500667e-07 6.399941e-06 11 125569446 125569457 12 + 2.052 1.293 -2.582
ENSG00000149547 E008 154.8017206 4.727695e-02 8.783774e-04 3.538595e-03 11 125569458 125569476 19 + 2.359 2.025 -1.115
ENSG00000149547 E009 235.9313675 3.122548e-02 2.865415e-04 1.325148e-03 11 125569477 125569488 12 + 2.522 2.224 -0.993
ENSG00000149547 E010 442.8722083 1.455285e-02 1.363819e-04 6.875419e-04 11 125569489 125569514 26 + 2.748 2.534 -0.712
ENSG00000149547 E011 655.6603074 9.219133e-03 8.589452e-05 4.557984e-04 11 125569515 125569573 59 + 2.893 2.721 -0.572
ENSG00000149547 E012 3.5334219 4.380516e-03 9.778092e-05 5.116504e-04 11 125569574 125569577 4 + 0.935 0.384 -2.420
ENSG00000149547 E013 1.5071705 9.804402e-03 1.835450e-01 3.056560e-01 11 125569840 125569858 19 + 0.510 0.290 -1.237
ENSG00000149547 E014 4.1932981 3.978287e-03 7.970130e-01 8.704850e-01 11 125569859 125569947 89 + 0.701 0.680 -0.087
ENSG00000149547 E015 69.7666874 1.507729e-03 1.069116e-04 5.539046e-04 11 125570104 125570190 87 + 1.918 1.757 -0.543
ENSG00000149547 E016 1358.2746048 2.338571e-03 1.637138e-05 1.035735e-04 11 125572458 125572569 112 + 3.158 3.068 -0.299
ENSG00000149547 E017 11.0233977 5.152447e-03 3.085178e-01 4.508050e-01 11 125575251 125575262 12 + 1.101 1.011 -0.329
ENSG00000149547 E018 1103.9198276 4.022338e-04 2.212404e-05 1.357780e-04 11 125575263 125575304 42 + 3.038 2.996 -0.141
ENSG00000149547 E019 897.3962259 4.929663e-04 5.525470e-05 3.079262e-04 11 125575305 125575308 4 + 2.950 2.904 -0.153
ENSG00000149547 E020 1985.0253903 2.787423e-04 3.326871e-07 3.049034e-06 11 125575309 125575408 100 + 3.290 3.252 -0.125
ENSG00000149547 E021 4.4975036 5.484563e-02 3.371376e-02 7.918388e-02 11 125575803 125575931 129 + 0.912 0.584 -1.334
ENSG00000149547 E022 1796.2073498 8.646894e-05 3.716129e-05 2.158346e-04 11 125576255 125576315 61 + 3.234 3.215 -0.062
ENSG00000149547 E023 1720.6339383 2.931462e-04 3.427595e-06 2.533842e-05 11 125577504 125577570 67 + 3.226 3.190 -0.118
ENSG00000149547 E024 8.0362138 7.380529e-03 5.282610e-01 6.611839e-01 11 125577571 125577735 165 + 0.957 0.897 -0.226
ENSG00000149547 E025 9.6632808 6.648114e-03 1.644933e-02 4.372433e-02 11 125577736 125577906 171 + 1.159 0.920 -0.875
ENSG00000149547 E026 2157.7207721 3.290551e-04 1.658140e-04 8.171736e-04 11 125578133 125578257 125 + 3.316 3.292 -0.078
ENSG00000149547 E027 2002.6524970 1.204317e-03 7.320111e-01 8.235728e-01 11 125578949 125579068 120 + 3.250 3.274 0.081
ENSG00000149547 E028 2021.8011527 2.558306e-04 1.084199e-04 5.608132e-04 11 125580093 125580204 112 + 3.227 3.291 0.210
ENSG00000149547 E029 8.1127594 1.874600e-02 2.732400e-03 9.470096e-03 11 125580780 125581210 431 + 1.145 0.791 -1.323
ENSG00000149547 E030 1858.5986621 2.016999e-04 1.592755e-08 1.891092e-07 11 125581211 125581322 112 + 3.177 3.260 0.274
ENSG00000149547 E031 1745.5510057 1.076635e-03 5.114510e-04 2.202611e-03 11 125582346 125582420 75 + 3.149 3.231 0.271
ENSG00000149547 E032 8688.2458449 1.718397e-03 3.662143e-11 6.946851e-10 11 125583521 125584684 1164 + 3.817 3.936 0.396