ENSG00000149503

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000278849 ENSG00000149503 HEK293_OSMI2_2hA HEK293_TMG_2hB INCENP protein_coding protein_coding 36.87599 31.21026 41.51201 1.53232 1.059834 0.4113937 22.060275 19.787236 22.856273 1.2787918 0.7570538 0.2079222 0.6035917 0.6338000 0.55116667 -0.08263333 2.120557e-01 7.87148e-17 FALSE TRUE
ENST00000394818 ENSG00000149503 HEK293_OSMI2_2hA HEK293_TMG_2hB INCENP protein_coding protein_coding 36.87599 31.21026 41.51201 1.53232 1.059834 0.4113937 0.888234 0.000000 2.360704 0.0000000 0.3203272 7.8891715 0.0224125 0.0000000 0.05733333 0.05733333 7.871480e-17 7.87148e-17 FALSE TRUE
MSTRG.5589.5 ENSG00000149503 HEK293_OSMI2_2hA HEK293_TMG_2hB INCENP protein_coding   36.87599 31.21026 41.51201 1.53232 1.059834 0.4113937 6.362820 5.088067 10.046689 0.9702154 1.1880629 0.9801332 0.1727375 0.1649667 0.24306667 0.07810000 4.378177e-01 7.87148e-17 FALSE TRUE
MSTRG.5589.6 ENSG00000149503 HEK293_OSMI2_2hA HEK293_TMG_2hB INCENP protein_coding   36.87599 31.21026 41.51201 1.53232 1.059834 0.4113937 4.316900 5.616123 2.405744 0.9993894 1.2383733 -1.2196736 0.1182042 0.1776333 0.05660000 -0.12103333 4.998823e-01 7.87148e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000149503 E001 0.147249 0.0426610211 5.306019e-01   11 62123998 62124002 5 + 0.118 0.000 -10.736
ENSG00000149503 E002 0.147249 0.0426610211 5.306019e-01   11 62124003 62124005 3 + 0.118 0.000 -10.738
ENSG00000149503 E003 0.147249 0.0426610211 5.306019e-01   11 62124006 62124009 4 + 0.118 0.000 -10.738
ENSG00000149503 E004 0.294498 0.2956563782 2.988491e-01   11 62124010 62124010 1 + 0.211 0.000 -11.737
ENSG00000149503 E005 76.342941 0.0003716257 1.842004e-04 8.958544e-04 11 62124011 62124055 45 + 1.960 1.801 -0.532
ENSG00000149503 E006 201.861157 0.0004368193 2.386310e-06 1.825550e-05 11 62124056 62124163 108 + 2.367 2.238 -0.432
ENSG00000149503 E007 331.027318 0.0006841721 6.273494e-05 3.448510e-04 11 62128151 62128301 151 + 2.566 2.471 -0.317
ENSG00000149503 E008 299.395198 0.0002265448 2.433370e-04 1.147301e-03 11 62128770 62128883 114 + 2.515 2.433 -0.275
ENSG00000149503 E009 851.573488 0.0009117567 1.532527e-02 4.122636e-02 11 62129782 62130558 777 + 2.952 2.906 -0.152
ENSG00000149503 E010 154.686296 0.0057266783 4.777801e-01 6.162824e-01 11 62130559 62130590 32 + 2.210 2.173 -0.124
ENSG00000149503 E011 189.139777 0.0036277809 6.385814e-01 7.521937e-01 11 62137832 62137883 52 + 2.288 2.266 -0.074
ENSG00000149503 E012 1.284579 0.0108647759 8.997557e-01 9.400373e-01 11 62137884 62137976 93 + 0.352 0.372 0.113
ENSG00000149503 E013 208.217367 0.0017174297 7.099389e-01 8.071863e-01 11 62138713 62138770 58 + 2.327 2.310 -0.054
ENSG00000149503 E014 314.299003 0.0002913383 1.247565e-01 2.267861e-01 11 62138888 62139005 118 + 2.514 2.477 -0.124
ENSG00000149503 E015 235.598208 0.0019509974 2.882982e-02 6.966662e-02 11 62140234 62140285 52 + 2.408 2.336 -0.240
ENSG00000149503 E016 282.269042 0.0002011687 1.650594e-01 2.817753e-01 11 62140704 62140821 118 + 2.468 2.433 -0.116
ENSG00000149503 E017 265.644115 0.0008128945 5.341437e-01 6.662579e-01 11 62140913 62141044 132 + 2.416 2.427 0.037
ENSG00000149503 E018 20.268969 0.0018042436 6.996053e-01 7.992747e-01 11 62141500 62141511 12 + 1.335 1.301 -0.121
ENSG00000149503 E019 9.533265 0.0018441491 4.971638e-02 1.086584e-01 11 62141512 62141745 234 + 1.121 0.909 -0.780
ENSG00000149503 E020 281.530813 0.0009647876 1.021307e-03 4.032671e-03 11 62144982 62145091 110 + 2.402 2.482 0.267
ENSG00000149503 E021 313.735250 0.0015964493 9.706507e-03 2.803874e-02 11 62145169 62145289 121 + 2.459 2.525 0.223
ENSG00000149503 E022 325.113002 0.0023580023 1.841495e-02 4.804320e-02 11 62145629 62145751 123 + 2.473 2.542 0.230
ENSG00000149503 E023 57.169682 0.0016727052 2.086116e-02 5.329490e-02 11 62145752 62145763 12 + 1.697 1.809 0.377
ENSG00000149503 E024 342.487088 0.0006314866 3.880730e-03 1.280868e-02 11 62146658 62146902 245 + 2.500 2.560 0.199
ENSG00000149503 E025 173.941983 0.0002536895 1.035991e-05 6.862905e-05 11 62148476 62148554 79 + 2.176 2.292 0.389
ENSG00000149503 E026 238.850203 0.0002220508 1.348517e-12 3.235467e-11 11 62148739 62148846 108 + 2.285 2.448 0.544
ENSG00000149503 E027 355.510702 0.0015393021 5.710978e-06 4.011894e-05 11 62150057 62150207 151 + 2.486 2.602 0.385
ENSG00000149503 E028 835.233314 0.0004665233 5.843134e-05 3.236643e-04 11 62151762 62152481 720 + 2.890 2.946 0.187
ENSG00000149503 E029 146.442612 0.0031713898 8.527623e-02 1.678510e-01 11 62152482 62152551 70 + 2.204 2.133 -0.237
ENSG00000149503 E030 166.845760 0.0082827660 3.310358e-02 7.801614e-02 11 62152552 62152672 121 + 2.281 2.167 -0.381
ENSG00000149503 E031 526.811127 0.0028552241 1.191450e-03 4.612204e-03 11 62152673 62153224 552 + 2.770 2.673 -0.321