ENSG00000149499

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000278845 ENSG00000149499 HEK293_OSMI2_2hA HEK293_TMG_2hB EML3 protein_coding protein_coding 12.1314 17.02658 9.250535 1.930819 0.9987226 -0.879468 0.7973981 1.926240 0.5978605 1.00708047 0.3110305 -1.67144576 0.05850000 0.11363333 0.06383333 -0.04980000 0.94272276 0.001052935 FALSE  
ENST00000394773 ENSG00000149499 HEK293_OSMI2_2hA HEK293_TMG_2hB EML3 protein_coding protein_coding 12.1314 17.02658 9.250535 1.930819 0.9987226 -0.879468 2.3244753 3.944553 1.9431026 0.73499395 0.4769643 -1.01774676 0.19503333 0.24416667 0.22390000 -0.02026667 0.93402389 0.001052935 FALSE  
ENST00000439994 ENSG00000149499 HEK293_OSMI2_2hA HEK293_TMG_2hB EML3 protein_coding protein_coding 12.1314 17.02658 9.250535 1.930819 0.9987226 -0.879468 1.0231872 0.636016 0.6651132 0.32852327 0.3492528 0.06355945 0.08936667 0.03443333 0.06746667 0.03303333 0.92358803 0.001052935 FALSE  
ENST00000460939 ENSG00000149499 HEK293_OSMI2_2hA HEK293_TMG_2hB EML3 protein_coding retained_intron 12.1314 17.02658 9.250535 1.930819 0.9987226 -0.879468 1.6111876 1.876459 1.1337557 0.25377808 0.1379246 -0.72190170 0.13423333 0.11016667 0.12696667 0.01680000 0.86160433 0.001052935 TRUE  
ENST00000524518 ENSG00000149499 HEK293_OSMI2_2hA HEK293_TMG_2hB EML3 protein_coding retained_intron 12.1314 17.02658 9.250535 1.930819 0.9987226 -0.879468 0.8067950 0.406186 0.8094159 0.01031531 0.3286037 0.97736725 0.07763333 0.02433333 0.08293333 0.05860000 0.04507298 0.001052935    
ENST00000531557 ENSG00000149499 HEK293_OSMI2_2hA HEK293_TMG_2hB EML3 protein_coding protein_coding 12.1314 17.02658 9.250535 1.930819 0.9987226 -0.879468 2.0686564 4.303102 1.0163931 1.49585779 0.5899270 -2.07114234 0.14930417 0.24876667 0.10063333 -0.14813333 0.60291061 0.001052935 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000149499 E001 42.8341400 0.0005454026 2.786041e-04 1.292726e-03 11 62602218 62602218 1 - 1.723 1.519 -0.697
ENSG00000149499 E002 41.5473851 0.0006576432 2.517252e-04 1.182430e-03 11 62602219 62602219 1 - 1.714 1.505 -0.713
ENSG00000149499 E003 45.6225895 0.0005354030 1.246041e-03 4.796673e-03 11 62602220 62602225 6 - 1.732 1.554 -0.605
ENSG00000149499 E004 96.7794886 0.0003089472 1.086102e-05 7.157074e-05 11 62602226 62602353 128 - 2.042 1.873 -0.567
ENSG00000149499 E005 76.2872533 0.0003978262 1.337569e-02 3.679267e-02 11 62602354 62602595 242 - 1.728 1.845 0.397
ENSG00000149499 E006 61.6222757 0.0004441443 3.225489e-05 1.903671e-04 11 62602596 62602678 83 - 1.543 1.774 0.786
ENSG00000149499 E007 3.3245432 0.0046443326 9.830427e-02 1.879385e-01 11 62602679 62602758 80 - 0.761 0.505 -1.114
ENSG00000149499 E008 43.9318864 0.0005264894 4.332116e-03 1.407513e-02 11 62602759 62602779 21 - 1.439 1.621 0.625
ENSG00000149499 E009 76.9370376 0.0011076488 3.996316e-03 1.313366e-02 11 62602780 62602889 110 - 1.710 1.854 0.485
ENSG00000149499 E010 20.9766727 0.0249384007 2.475961e-01 3.831215e-01 11 62602890 62603115 226 - 1.366 1.244 -0.425
ENSG00000149499 E011 9.0092188 0.0669161279 4.333746e-01 5.757752e-01 11 62603116 62603148 33 - 1.022 0.922 -0.371
ENSG00000149499 E012 88.6791999 0.0103841267 2.453779e-01 3.804785e-01 11 62603149 62603247 99 - 1.820 1.903 0.278
ENSG00000149499 E013 96.4939393 0.0025981901 1.201395e-01 2.201912e-01 11 62603729 62603816 88 - 1.860 1.936 0.255
ENSG00000149499 E014 105.6089240 0.0019863790 2.421427e-03 8.525986e-03 11 62603944 62604041 98 - 1.844 1.984 0.470
ENSG00000149499 E015 9.5296401 0.0120162377 6.887358e-02 1.415019e-01 11 62604042 62604072 31 - 1.102 0.884 -0.808
ENSG00000149499 E016 9.3625958 0.0022290379 1.327912e-01 2.379892e-01 11 62604073 62604112 40 - 1.064 0.893 -0.637
ENSG00000149499 E017 94.6927757 0.0003233816 7.581220e-04 3.108676e-03 11 62604113 62604201 89 - 1.792 1.938 0.493
ENSG00000149499 E018 7.2857671 0.0521262571 5.925928e-04 2.506529e-03 11 62604708 62605112 405 - 1.198 0.661 -2.045
ENSG00000149499 E019 88.5172515 0.0003359803 9.172337e-02 1.778211e-01 11 62605113 62605180 68 - 1.824 1.897 0.246
ENSG00000149499 E020 3.8793100 0.0043144817 1.380185e-02 3.777712e-02 11 62605181 62605229 49 - 0.866 0.506 -1.528
ENSG00000149499 E021 1.9414315 0.1581206569 1.529568e-03 5.732839e-03 11 62605596 62605641 46 - 0.833 0.145 -3.868
ENSG00000149499 E022 110.9095401 0.0003479718 3.250420e-01 4.684786e-01 11 62605642 62605773 132 - 1.949 1.986 0.125
ENSG00000149499 E023 1.8446462 0.0081198866 6.831266e-05 3.720034e-04 11 62605837 62605854 18 - 0.799 0.146 -3.726
ENSG00000149499 E024 69.9160553 0.0006427984 1.509033e-01 2.628942e-01 11 62605855 62605909 55 - 1.723 1.794 0.240
ENSG00000149499 E025 68.3423482 0.0045774194 2.290381e-01 3.612842e-01 11 62605910 62605980 71 - 1.710 1.782 0.243
ENSG00000149499 E026 2.3166814 0.0161811686 9.960137e-04 3.944144e-03 11 62605981 62606062 82 - 0.799 0.256 -2.720
ENSG00000149499 E027 101.9187470 0.0005706119 3.500018e-02 8.165558e-02 11 62606063 62606214 152 - 1.870 1.957 0.294
ENSG00000149499 E028 93.4637603 0.0003067835 6.379796e-01 7.517616e-01 11 62606958 62607099 142 - 1.888 1.907 0.063
ENSG00000149499 E029 3.1604718 0.0055282540 2.792156e-03 9.649839e-03 11 62607100 62607392 293 - 0.866 0.415 -1.989
ENSG00000149499 E030 76.7980895 0.0003510927 5.680259e-01 6.947429e-01 11 62607666 62607821 156 - 1.841 1.814 -0.089
ENSG00000149499 E031 0.8836079 0.0136968632 1.780828e-04 8.698309e-04 11 62607866 62608200 335 - 0.621 0.000 -12.920
ENSG00000149499 E032 78.1159241 0.0003841334 8.120037e-01 8.807190e-01 11 62608201 62608296 96 - 1.834 1.823 -0.039
ENSG00000149499 E033 82.4577466 0.0003977031 3.203034e-01 4.634011e-01 11 62608542 62608652 111 - 1.882 1.838 -0.148
ENSG00000149499 E034 62.6904225 0.0004037905 2.241777e-02 5.654629e-02 11 62608736 62608805 70 - 1.817 1.706 -0.374
ENSG00000149499 E035 89.3684189 0.0003303775 6.279340e-04 2.635485e-03 11 62608962 62609132 171 - 1.986 1.848 -0.464
ENSG00000149499 E036 65.8842963 0.0003820611 1.252298e-01 2.274578e-01 11 62609354 62609477 124 - 1.810 1.736 -0.250
ENSG00000149499 E037 47.4063833 0.0005221486 5.794305e-01 7.043399e-01 11 62609629 62609696 68 - 1.637 1.605 -0.110
ENSG00000149499 E038 45.4802904 0.0005726523 3.872323e-01 5.313747e-01 11 62610879 62610954 76 - 1.556 1.607 0.174
ENSG00000149499 E039 29.0843161 0.0007580758 8.781857e-01 9.257725e-01 11 62610955 62610975 21 - 1.395 1.405 0.036
ENSG00000149499 E040 23.6823863 0.0008186888 6.155299e-01 7.337903e-01 11 62610976 62610976 1 - 1.291 1.331 0.140
ENSG00000149499 E041 26.6318014 0.0007514416 3.370068e-01 4.808686e-01 11 62610977 62610992 16 - 1.314 1.388 0.257
ENSG00000149499 E042 0.0000000       11 62610993 62611007 15 -      
ENSG00000149499 E043 30.5744590 0.0006759865 2.453824e-01 3.804793e-01 11 62611087 62611111 25 - 1.366 1.450 0.291
ENSG00000149499 E044 71.8926512 0.0056312315 4.069691e-01 5.506038e-01 11 62611112 62611344 233 - 1.753 1.803 0.170
ENSG00000149499 E045 11.0176168 0.0400831662 4.372108e-01 5.792146e-01 11 62611345 62611347 3 - 1.083 0.981 -0.374
ENSG00000149499 E046 47.0949098 0.0413148665 9.614733e-01 9.797391e-01 11 62611425 62611596 172 - 1.609 1.615 0.021
ENSG00000149499 E047 5.3715970 0.0040997430 4.755936e-08 5.154449e-07 11 62611597 62612164 568 - 1.153 0.447 -2.877
ENSG00000149499 E048 1.5029041 0.0104466201 8.194975e-02 1.626111e-01 11 62612165 62612224 60 - 0.562 0.256 -1.724
ENSG00000149499 E049 1.1782171 0.0984985985 1.414395e-01 2.499934e-01 11 62612225 62612381 157 - 0.494 0.205 -1.806
ENSG00000149499 E050 17.9893092 0.1028753557 7.924413e-01 8.672958e-01 11 62612436 62612573 138 - 1.183 1.222 0.141
ENSG00000149499 E051 6.1684922 0.0990484142 1.174259e-01 2.162745e-01 11 62612574 62612775 202 - 0.976 0.709 -1.042