ENSG00000149483

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000278826 ENSG00000149483 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM138 protein_coding protein_coding 36.48061 45.28359 28.6262 1.946753 0.6088871 -0.6614669 18.050136 29.4439640 10.717797 0.8540162 0.4657620 -1.45710801 0.4789917 0.6513667 0.3753333 -0.27603333 5.065258e-09 5.065258e-09 FALSE TRUE
ENST00000545420 ENSG00000149483 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM138 protein_coding processed_transcript 36.48061 45.28359 28.6262 1.946753 0.6088871 -0.6614669 5.055340 4.7315128 4.432311 0.7580670 0.7462446 -0.09403702 0.1388250 0.1036667 0.1540000 0.05033333 3.104869e-01 5.065258e-09 FALSE FALSE
MSTRG.5565.20 ENSG00000149483 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM138 protein_coding   36.48061 45.28359 28.6262 1.946753 0.6088871 -0.6614669 3.650754 0.5371106 4.283299 0.3254026 0.6851565 2.97218218 0.1116875 0.0114000 0.1489000 0.13750000 1.649884e-02 5.065258e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000149483 E001 15.1256431 0.0526147884 4.065570e-02 9.223741e-02 11 61361964 61362152 189 + 1.347 1.055 -1.039
ENSG00000149483 E002 21.6839381 0.0382256703 6.948784e-03 2.109047e-02 11 61362153 61362343 191 + 1.514 1.188 -1.134
ENSG00000149483 E003 7.8809881 0.0609168110 2.727705e-01 4.117245e-01 11 61362344 61362360 17 + 1.021 0.844 -0.663
ENSG00000149483 E004 7.6791227 0.0063348998 1.879061e-01 3.110925e-01 11 61362361 61362366 6 + 1.001 0.838 -0.615
ENSG00000149483 E005 13.7722466 0.0066267815 9.030522e-02 1.756005e-01 11 61362367 61362373 7 + 1.236 1.065 -0.611
ENSG00000149483 E006 21.8740272 0.0016438498 1.295006e-02 3.579443e-02 11 61362374 61362380 7 + 1.441 1.248 -0.671
ENSG00000149483 E007 43.0350721 0.0004829580 3.358638e-01 4.796894e-01 11 61362381 61362385 5 + 1.646 1.589 -0.194
ENSG00000149483 E008 45.4373119 0.0004839700 4.043057e-01 5.480161e-01 11 61362386 61362388 3 + 1.663 1.615 -0.166
ENSG00000149483 E009 81.4218941 0.0003348544 6.421868e-01 7.550303e-01 11 61362389 61362396 8 + 1.895 1.872 -0.076
ENSG00000149483 E010 116.7895141 0.0003210022 1.402378e-01 2.483397e-01 11 61362397 61362409 13 + 2.071 2.017 -0.182
ENSG00000149483 E011 138.5689106 0.0002552406 5.074210e-01 6.429543e-01 11 61362410 61362420 11 + 2.126 2.101 -0.082
ENSG00000149483 E012 0.7750806 0.0244336466 4.051047e-02 9.195526e-02 11 61362421 61362432 12 + 0.448 0.092 -2.940
ENSG00000149483 E013 5.1561482 0.0241154534 5.280762e-01 6.609744e-01 11 61362433 61362625 193 + 0.704 0.803 0.398
ENSG00000149483 E014 1.2950868 0.0124959714 5.724982e-01 6.986072e-01 11 61362626 61362668 43 + 0.279 0.381 0.642
ENSG00000149483 E015 5.5176565 0.0030209440 8.947628e-01 9.367426e-01 11 61362669 61363498 830 + 0.775 0.790 0.060
ENSG00000149483 E016 3.7421020 0.0473800281 5.810710e-01 7.056695e-01 11 61363499 61363868 370 + 0.704 0.611 -0.397
ENSG00000149483 E017 2.0866147 0.0947731893 1.069676e-01 2.010625e-01 11 61363869 61364249 381 + 0.663 0.338 -1.609
ENSG00000149483 E018 0.8052565 0.2808053019 4.135860e-01 5.570476e-01 11 61364250 61364251 2 + 0.370 0.168 -1.514
ENSG00000149483 E019 196.8831879 0.0002077505 4.349735e-01 5.772113e-01 11 61364252 61364315 64 + 2.247 2.265 0.058
ENSG00000149483 E020 268.2406761 0.0002045264 8.443280e-01 9.031110e-01 11 61364316 61364432 117 + 2.393 2.394 0.003
ENSG00000149483 E021 269.9657475 0.0001562986 8.002561e-03 2.378657e-02 11 61364433 61364518 86 + 2.355 2.412 0.191
ENSG00000149483 E022 17.5652432 0.0010532689 2.843245e-02 6.887988e-02 11 61364519 61364870 352 + 1.355 1.172 -0.642
ENSG00000149483 E023 7.1579758 0.0024096948 2.998963e-05 1.784878e-04 11 61365703 61366044 342 + 1.148 0.656 -1.890
ENSG00000149483 E024 435.5527841 0.0001452302 1.496590e-01 2.612129e-01 11 61366045 61366216 172 + 2.587 2.609 0.073
ENSG00000149483 E025 43.0921600 0.0021592084 3.012896e-19 1.764948e-17 11 61366217 61366978 762 + 1.893 1.381 -1.742
ENSG00000149483 E026 32.2179948 0.0006323421 2.210648e-11 4.354342e-10 11 61366979 61367427 449 + 1.727 1.317 -1.406
ENSG00000149483 E027 34.6373942 0.0214842439 4.951218e-05 2.792977e-04 11 61367428 61367904 477 + 1.734 1.361 -1.277
ENSG00000149483 E028 11.4140061 0.0461728391 6.590760e-03 2.016179e-02 11 61367905 61367922 18 + 1.279 0.900 -1.374
ENSG00000149483 E029 306.7132748 0.0002578952 1.554346e-01 2.689788e-01 11 61367923 61367998 76 + 2.432 2.460 0.091
ENSG00000149483 E030 27.0391743 0.0069954566 1.890842e-07 1.820380e-06 11 61367999 61368251 253 + 1.646 1.243 -1.391
ENSG00000149483 E031 6.8631736 0.0053303874 9.490581e-03 2.751365e-02 11 61368252 61368269 18 + 1.056 0.738 -1.215
ENSG00000149483 E032 30.9560398 0.0011488702 1.466484e-09 2.106620e-08 11 61368270 61368596 327 + 1.696 1.312 -1.319
ENSG00000149483 E033 146.9594478 0.0003571772 1.511428e-03 5.673267e-03 11 61368597 61368599 3 + 2.063 2.161 0.331
ENSG00000149483 E034 335.9303892 0.0001469895 2.574086e-11 5.014425e-10 11 61368600 61368771 172 + 2.390 2.527 0.455
ENSG00000149483 E035 456.7526289 0.0011825262 3.756058e-13 9.848774e-12 11 61368772 61369509 738 + 2.504 2.667 0.546
ENSG00000149483 E036 15.3405225 0.0158419522 3.657220e-04 1.641628e-03 11 61373043 61373492 450 + 1.396 1.028 -1.307
ENSG00000149483 E037 1.2200474 0.0127048557 2.289351e-01 3.611758e-01 11 61375195 61375307 113 + 0.448 0.232 -1.352
ENSG00000149483 E038 9.2830997 0.0018238141 4.045213e-06 2.938585e-05 11 61376463 61376554 92 + 1.258 0.773 -1.796
ENSG00000149483 E039 34.9869046 0.0300444659 9.815514e-07 8.156146e-06 11 61376555 61377890 1336 + 1.804 1.312 -1.683