ENSG00000149428

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000614711 ENSG00000149428 HEK293_OSMI2_2hA HEK293_TMG_2hB HYOU1 protein_coding protein_coding 140.6475 125.626 181.5001 3.38997 2.410284 0.5308004 52.999949 47.890250 74.98933001 1.878723 4.1693520 0.6468445 0.37604583 0.3816333 0.41300000 0.03136667 6.878698e-01 5.506246e-57 FALSE TRUE
ENST00000617285 ENSG00000149428 HEK293_OSMI2_2hA HEK293_TMG_2hB HYOU1 protein_coding protein_coding 140.6475 125.626 181.5001 3.38997 2.410284 0.5308004 27.055347 30.541825 18.80813968 3.670024 4.6896939 -0.6991346 0.20186667 0.2419000 0.10410000 -0.13780000 4.493223e-02 5.506246e-57 FALSE TRUE
ENST00000622474 ENSG00000149428 HEK293_OSMI2_2hA HEK293_TMG_2hB HYOU1 protein_coding retained_intron 140.6475 125.626 181.5001 3.38997 2.410284 0.5308004 3.820699 0.000000 13.66417108 0.000000 2.3890487 10.4172377 0.01894583 0.0000000 0.07496667 0.07496667 4.487855e-29 5.506246e-57 FALSE TRUE
ENST00000652093 ENSG00000149428 HEK293_OSMI2_2hA HEK293_TMG_2hB HYOU1 protein_coding protein_coding 140.6475 125.626 181.5001 3.38997 2.410284 0.5308004 21.718497 26.005510 7.59506996 1.424842 4.5401688 -1.7743386 0.17140417 0.2067000 0.04200000 -0.16470000 3.871724e-01 5.506246e-57 FALSE TRUE
ENST00000694928 ENSG00000149428 HEK293_OSMI2_2hA HEK293_TMG_2hB HYOU1 protein_coding protein_coding 140.6475 125.626 181.5001 3.38997 2.410284 0.5308004 2.068206 6.196984 0.09629999 4.285192 0.0683008 -5.8676790 0.01740000 0.0510000 0.00050000 -0.05050000 8.474813e-02 5.506246e-57 FALSE FALSE
ENST00000694935 ENSG00000149428 HEK293_OSMI2_2hA HEK293_TMG_2hB HYOU1 protein_coding protein_coding 140.6475 125.626 181.5001 3.38997 2.410284 0.5308004 9.042857 0.000000 32.36085465 0.000000 6.8918400 11.6604797 0.04695417 0.0000000 0.17790000 0.17790000 2.474429e-30 5.506246e-57 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000149428 E001 4.041808 4.092948e-03 3.972392e-03 1.306433e-02 11 119044188 119044191 4 - 0.442 0.873 1.872
ENSG00000149428 E002 57.310130 2.203773e-02 1.761307e-06 1.386669e-05 11 119044192 119044259 68 - 1.500 1.934 1.471
ENSG00000149428 E003 108.833823 1.988762e-02 2.576770e-08 2.940376e-07 11 119044260 119044310 51 - 1.763 2.211 1.506
ENSG00000149428 E004 450.448066 1.071941e-02 2.680243e-11 5.203034e-10 11 119044311 119044427 117 - 2.429 2.804 1.249
ENSG00000149428 E005 301.548533 1.158675e-02 7.095416e-09 8.991339e-08 11 119044428 119044437 10 - 2.276 2.621 1.153
ENSG00000149428 E006 342.909031 7.624666e-03 1.267495e-08 1.532766e-07 11 119044438 119044451 14 - 2.374 2.657 0.944
ENSG00000149428 E007 898.161685 6.223889e-03 1.602534e-06 1.272990e-05 11 119044452 119044528 77 - 2.838 3.046 0.694
ENSG00000149428 E008 888.133861 5.541917e-03 4.874729e-06 3.480283e-05 11 119044529 119044571 43 - 2.845 3.034 0.628
ENSG00000149428 E009 2490.024574 3.754143e-03 3.453475e-08 3.843332e-07 11 119044572 119044907 336 - 3.299 3.476 0.588
ENSG00000149428 E010 1775.569239 2.212318e-03 3.698449e-12 8.262501e-11 11 119044908 119045126 219 - 3.151 3.331 0.598
ENSG00000149428 E011 1528.941689 1.490652e-03 1.942963e-17 9.154154e-16 11 119045127 119045310 184 - 3.081 3.269 0.625
ENSG00000149428 E012 1577.213501 1.031164e-04 1.643539e-52 1.148943e-49 11 119045311 119045589 279 - 3.108 3.272 0.544
ENSG00000149428 E013 943.521852 2.088311e-04 3.444605e-18 1.775701e-16 11 119045590 119045654 65 - 2.907 3.034 0.422
ENSG00000149428 E014 4.173718 3.831346e-03 1.561498e-01 2.700084e-01 11 119045655 119045780 126 - 0.596 0.806 0.872
ENSG00000149428 E015 895.981301 1.070453e-04 4.001212e-12 8.887289e-11 11 119045781 119045831 51 - 2.900 2.999 0.327
ENSG00000149428 E016 123.930198 2.628441e-04 1.446210e-02 3.927299e-02 11 119045832 119045834 3 - 2.049 2.139 0.299
ENSG00000149428 E017 926.556826 6.674973e-04 1.437664e-02 3.908048e-02 11 119046417 119046462 46 - 2.940 2.993 0.175
ENSG00000149428 E018 667.027110 5.571847e-04 7.850288e-01 8.621677e-01 11 119046463 119046467 5 - 2.816 2.832 0.051
ENSG00000149428 E019 1766.715912 4.488318e-04 2.268827e-02 5.710789e-02 11 119046562 119046802 241 - 3.227 3.267 0.136
ENSG00000149428 E020 8.385782 1.490814e-02 2.316580e-01 3.644288e-01 11 119046803 119046831 29 - 0.890 1.044 0.572
ENSG00000149428 E021 21.804199 9.209936e-04 1.728623e-01 2.919157e-01 11 119047170 119047733 564 - 1.401 1.310 -0.315
ENSG00000149428 E022 972.337396 1.435265e-03 6.131630e-01 7.319451e-01 11 119047734 119047818 85 - 2.977 3.000 0.074
ENSG00000149428 E023 1302.204745 6.738612e-05 1.285069e-01 2.320782e-01 11 119047947 119048080 134 - 3.101 3.128 0.087
ENSG00000149428 E024 8.847607 1.939690e-03 4.981757e-01 6.346738e-01 11 119048081 119048106 26 - 1.030 0.967 -0.234
ENSG00000149428 E025 1269.924919 8.625725e-05 1.692290e-01 2.871878e-01 11 119048248 119048356 109 - 3.105 3.100 -0.014
ENSG00000149428 E026 679.933278 1.222752e-04 1.513393e-01 2.634915e-01 11 119048357 119048359 3 - 2.837 2.827 -0.034
ENSG00000149428 E027 717.535817 1.639376e-04 1.439974e-01 2.534573e-01 11 119048360 119048370 11 - 2.861 2.850 -0.036
ENSG00000149428 E028 9.841937 1.722847e-03 3.565689e-01 5.009485e-01 11 119048371 119048475 105 - 0.980 1.084 0.384
ENSG00000149428 E029 1066.321021 5.257956e-04 7.233879e-01 8.172344e-01 11 119048476 119048563 88 - 3.024 3.030 0.017
ENSG00000149428 E030 1543.078830 9.355565e-04 1.220634e-01 2.228829e-01 11 119048714 119048886 173 - 3.195 3.180 -0.051
ENSG00000149428 E031 868.890293 1.481815e-03 1.571047e-03 5.865096e-03 11 119049018 119049050 33 - 2.966 2.907 -0.196
ENSG00000149428 E032 1480.630356 6.216516e-04 3.410097e-05 2.000473e-04 11 119049051 119049200 150 - 3.195 3.143 -0.170
ENSG00000149428 E033 689.692327 1.124188e-03 1.191595e-05 7.779988e-05 11 119049201 119049203 3 - 2.877 2.795 -0.273
ENSG00000149428 E034 14.187726 2.587819e-02 7.364997e-01 8.269776e-01 11 119049204 119049370 167 - 1.189 1.159 -0.104
ENSG00000149428 E035 1162.121087 2.008139e-03 2.868935e-05 1.714708e-04 11 119049556 119049635 80 - 3.107 3.018 -0.296
ENSG00000149428 E036 7.015977 1.521677e-01 3.339655e-02 7.856838e-02 11 119049636 119049776 141 - 1.053 0.641 -1.609
ENSG00000149428 E037 1052.484352 8.092645e-04 2.413012e-09 3.331423e-08 11 119049777 119049837 61 - 3.066 2.972 -0.312
ENSG00000149428 E038 1357.773820 6.902443e-04 4.522651e-12 9.955876e-11 11 119051035 119051173 139 - 3.179 3.080 -0.329
ENSG00000149428 E039 1412.601112 2.944454e-04 3.707480e-15 1.299965e-13 11 119051438 119051625 188 - 3.191 3.104 -0.290
ENSG00000149428 E040 1106.211335 7.975587e-05 9.611345e-10 1.429792e-08 11 119051819 119051951 133 - 3.072 3.013 -0.196
ENSG00000149428 E041 922.398295 2.006795e-04 2.000945e-08 2.332900e-07 11 119052090 119052172 83 - 2.995 2.930 -0.216
ENSG00000149428 E042 1066.047820 1.925358e-03 9.609515e-04 3.824968e-03 11 119052295 119052429 135 - 3.059 2.993 -0.221
ENSG00000149428 E043 1119.956114 2.171358e-03 3.960472e-06 2.884104e-05 11 119052637 119052829 193 - 3.097 2.995 -0.341
ENSG00000149428 E044 670.446842 2.558046e-03 1.033151e-06 8.544062e-06 11 119054121 119054187 67 - 2.885 2.759 -0.420
ENSG00000149428 E045 554.247284 3.086395e-03 7.780160e-06 5.299611e-05 11 119054188 119054236 49 - 2.803 2.675 -0.425
ENSG00000149428 E046 653.180882 3.110825e-03 1.663164e-04 8.193935e-04 11 119054494 119054584 91 - 2.863 2.761 -0.342
ENSG00000149428 E047 597.942246 2.957232e-03 5.036253e-03 1.603023e-02 11 119054585 119054675 91 - 2.811 2.739 -0.241
ENSG00000149428 E048 7.957898 1.692816e-02 1.187045e-02 3.322175e-02 11 119054676 119054983 308 - 1.075 0.756 -1.214
ENSG00000149428 E049 579.815528 3.740315e-03 1.043576e-01 1.971268e-01 11 119054984 119055056 73 - 2.784 2.743 -0.137
ENSG00000149428 E050 336.365907 3.662728e-03 1.208777e-01 2.212019e-01 11 119055057 119055060 4 - 2.548 2.506 -0.141
ENSG00000149428 E051 4.297225 3.915618e-03 2.015406e-01 3.281022e-01 11 119055061 119055154 94 - 0.800 0.627 -0.712
ENSG00000149428 E052 4.252288 3.878229e-03 9.429192e-02 1.818205e-01 11 119055155 119055184 30 - 0.819 0.588 -0.960
ENSG00000149428 E053 414.473995 5.040551e-03 6.681915e-02 1.380913e-01 11 119055185 119055201 17 - 2.646 2.588 -0.191
ENSG00000149428 E054 904.584589 1.929915e-03 1.184172e-06 9.681418e-06 11 119055202 119055339 138 - 3.006 2.899 -0.355
ENSG00000149428 E055 1.632562 1.051799e-01 5.297608e-01 6.624922e-01 11 119055340 119055418 79 - 0.486 0.381 -0.552
ENSG00000149428 E056 765.456214 2.696851e-03 5.836368e-08 6.198813e-07 11 119055493 119055571 79 - 2.949 2.806 -0.473
ENSG00000149428 E057 7.949899 2.173189e-03 1.296060e-03 4.963103e-03 11 119055572 119055749 178 - 1.096 0.725 -1.413
ENSG00000149428 E058 722.843955 2.348259e-03 1.611984e-11 3.243950e-10 11 119055750 119055843 94 - 2.936 2.764 -0.572
ENSG00000149428 E059 644.196859 4.616125e-03 1.073662e-09 1.582895e-08 11 119056070 119056167 98 - 2.900 2.692 -0.693
ENSG00000149428 E060 5.092816 3.096523e-03 3.604439e-01 5.047502e-01 11 119056279 119056405 127 - 0.838 0.725 -0.449
ENSG00000149428 E061 3.129224 5.027013e-03 4.477775e-01 5.891328e-01 11 119056406 119056418 13 - 0.657 0.546 -0.488
ENSG00000149428 E062 8.570162 2.309698e-03 3.259335e-01 4.693849e-01 11 119056805 119057000 196 - 1.030 0.932 -0.365
ENSG00000149428 E063 3.774939 4.138825e-03 2.275892e-01 3.595164e-01 11 119057001 119057019 19 - 0.757 0.588 -0.713
ENSG00000149428 E064 203.264708 7.101127e-03 6.548393e-10 1.005408e-08 11 119057020 119057026 7 - 2.430 2.139 -0.971
ENSG00000149428 E065 273.204368 6.562640e-03 5.113595e-12 1.117301e-10 11 119057027 119057074 48 - 2.563 2.258 -1.017
ENSG00000149428 E066 206.770454 8.118582e-03 5.556553e-10 8.637665e-09 11 119057075 119057152 78 - 2.442 2.135 -1.028
ENSG00000149428 E067 119.457269 1.401439e-02 6.444675e-02 1.341203e-01 11 119057153 119057227 75 - 2.128 2.022 -0.357