ENSG00000149328

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000339772 ENSG00000149328 HEK293_OSMI2_2hA HEK293_TMG_2hB GLB1L2 protein_coding protein_coding 37.63109 54.94015 27.90624 1.727053 0.4486735 -0.9770188 34.71335 52.1393 24.31778 1.648052 0.06754693 -1.100043 0.9142708 0.949 0.8718 -0.0772 1.039972e-06 1.039972e-06 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000149328 E001 5.1265265 0.0828716290 6.914608e-02 1.419602e-01 11 134331874 134331974 101 + 0.932 0.626 -1.225
ENSG00000149328 E002 6.3253807 0.0943891777 1.675606e-01 2.850127e-01 11 134331975 134331987 13 + 0.977 0.732 -0.948
ENSG00000149328 E003 115.0913192 0.0112707913 1.415701e-02 3.858164e-02 11 134331988 134332147 160 + 2.107 1.976 -0.439
ENSG00000149328 E004 236.5034756 0.0059415328 1.980755e-02 5.107502e-02 11 134342754 134342951 198 + 2.385 2.304 -0.271
ENSG00000149328 E005 160.8762806 0.0019117681 3.389508e-02 7.954432e-02 11 134344387 134344455 69 + 2.203 2.146 -0.190
ENSG00000149328 E006 170.1024926 0.0084756742 4.988279e-02 1.089630e-01 11 134345034 134345129 96 + 2.242 2.163 -0.265
ENSG00000149328 E007 9.1858830 0.0497450560 4.301819e-03 1.398964e-02 11 134346390 134347142 753 + 1.220 0.805 -1.531
ENSG00000149328 E008 112.6468013 0.0049081521 5.547048e-03 1.741035e-02 11 134347325 134347335 11 + 2.086 1.972 -0.381
ENSG00000149328 E009 201.2759894 0.0034200620 5.897743e-03 1.834271e-02 11 134347336 134347433 98 + 2.316 2.232 -0.282
ENSG00000149328 E010 0.0000000       11 134356015 134356054 40 +      
ENSG00000149328 E011 212.3983289 0.0011824566 1.081054e-02 3.071054e-02 11 134356301 134356393 93 + 2.321 2.263 -0.194
ENSG00000149328 E012 208.0872713 0.0003685069 1.715915e-01 2.902766e-01 11 134359060 134359141 82 + 2.285 2.266 -0.063
ENSG00000149328 E013 5.8011471 0.0437616042 2.015931e-03 7.276177e-03 11 134359540 134360021 482 + 1.056 0.598 -1.812
ENSG00000149328 E014 12.2569523 0.0035163223 1.330154e-03 5.076322e-03 11 134360254 134361542 1289 + 1.266 0.969 -1.071
ENSG00000149328 E015 203.1986896 0.0028998389 1.844177e-01 3.067670e-01 11 134364328 134364398 71 + 2.281 2.253 -0.096
ENSG00000149328 E016 14.6625165 0.0012522023 4.689082e-04 2.041205e-03 11 134364399 134365080 682 + 1.338 1.045 -1.040
ENSG00000149328 E017 5.9724909 0.0619940878 3.599821e-01 5.042965e-01 11 134367055 134367139 85 + 0.882 0.749 -0.522
ENSG00000149328 E018 228.5231311 0.0040123622 1.745549e-01 2.941183e-01 11 134367257 134367341 85 + 2.334 2.303 -0.104
ENSG00000149328 E019 336.7099183 0.0001657997 3.082913e-04 1.413272e-03 11 134368644 134368781 138 + 2.520 2.463 -0.189
ENSG00000149328 E020 280.7309124 0.0001631678 8.705417e-03 2.555061e-02 11 134369805 134369885 81 + 2.432 2.391 -0.138
ENSG00000149328 E021 343.3563146 0.0003134173 1.753858e-05 1.101778e-04 11 134370293 134370399 107 + 2.540 2.467 -0.243
ENSG00000149328 E022 2.4356274 0.0084452540 8.361364e-02 1.651999e-01 11 134370400 134370426 27 + 0.679 0.410 -1.265
ENSG00000149328 E023 389.6615565 0.0001496876 1.645185e-05 1.040400e-04 11 134371008 134371148 141 + 2.589 2.524 -0.215
ENSG00000149328 E024 271.9775314 0.0001690875 7.356082e-01 8.263390e-01 11 134371421 134371492 72 + 2.380 2.391 0.036
ENSG00000149328 E025 324.4385244 0.0002695465 7.573695e-01 8.422177e-01 11 134371752 134371830 79 + 2.444 2.470 0.086
ENSG00000149328 E026 3.7786206 0.0119443279 6.299633e-01 7.452427e-01 11 134372430 134372598 169 + 0.679 0.618 -0.261
ENSG00000149328 E027 311.8481185 0.0004628190 4.802110e-02 1.056689e-01 11 134373721 134373808 88 + 2.397 2.464 0.222
ENSG00000149328 E028 373.2534366 0.0023957368 4.947663e-02 1.082331e-01 11 134374145 134374256 112 + 2.467 2.547 0.267
ENSG00000149328 E029 363.1157084 0.0007396275 5.165625e-03 1.637899e-02 11 134374602 134374718 117 + 2.451 2.538 0.289
ENSG00000149328 E030 1120.4312338 0.0013064832 8.442152e-13 2.097771e-11 11 134374972 134375656 685 + 2.884 3.043 0.529
ENSG00000149328 E031 763.6526298 0.0059676585 1.548687e-02 4.159965e-02 11 134375657 134375884 228 + 2.753 2.867 0.379
ENSG00000149328 E032 0.7718438 0.0325580765 7.888497e-01 8.648399e-01 11 134375885 134376024 140 + 0.168 0.224 0.520
ENSG00000149328 E033 3.0193725 0.0078086861 1.646968e-01 2.812936e-01 11 134376025 134376094 70 + 0.383 0.640 1.248
ENSG00000149328 E034 504.5772669 0.0064432630 2.146209e-01 3.439955e-01 11 134376095 134376324 230 + 2.604 2.678 0.247
ENSG00000149328 E035 2.4776455 0.0101585851 5.216673e-02 1.130190e-01 11 134377118 134377254 137 + 0.679 0.371 -1.482
ENSG00000149328 E036 0.9588613 0.0163765356 8.032730e-02 1.600712e-01 11 134378064 134378341 278 + 0.461 0.161 -2.072