ENSG00000149294

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000316851 ENSG00000149294 HEK293_OSMI2_2hA HEK293_TMG_2hB NCAM1 protein_coding protein_coding 11.1367 9.147871 14.10172 0.2429648 0.09854999 0.62381 5.6351440 5.582407 5.4468642 0.23538017 0.6385293 -0.03539724 0.5238750 0.6098000 0.3859000 -0.2239000 2.576994e-03 2.465099e-36 FALSE TRUE
ENST00000531044 ENSG00000149294 HEK293_OSMI2_2hA HEK293_TMG_2hB NCAM1 protein_coding protein_coding 11.1367 9.147871 14.10172 0.2429648 0.09854999 0.62381 1.9035786 0.000000 3.7987734 0.00000000 0.1697674 8.57318266 0.1471000 0.0000000 0.2694333 0.2694333 2.465099e-36 2.465099e-36 FALSE TRUE
ENST00000618266 ENSG00000149294 HEK293_OSMI2_2hA HEK293_TMG_2hB NCAM1 protein_coding protein_coding 11.1367 9.147871 14.10172 0.2429648 0.09854999 0.62381 0.8380192 1.678077 0.5289941 0.09998768 0.3616866 -1.64703938 0.0816875 0.1831333 0.0376000 -0.1455333 1.489254e-01 2.465099e-36 FALSE TRUE
MSTRG.6332.12 ENSG00000149294 HEK293_OSMI2_2hA HEK293_TMG_2hB NCAM1 protein_coding   11.1367 9.147871 14.10172 0.2429648 0.09854999 0.62381 0.2264820 0.000000 0.7111166 0.00000000 0.4552216 6.17216055 0.0177000 0.0000000 0.0508000 0.0508000 2.651625e-01 2.465099e-36 FALSE TRUE
MSTRG.6332.14 ENSG00000149294 HEK293_OSMI2_2hA HEK293_TMG_2hB NCAM1 protein_coding   11.1367 9.147871 14.10172 0.2429648 0.09854999 0.62381 1.0031919 1.032636 1.7378610 0.20092067 0.1042524 0.74535545 0.0902750 0.1138667 0.1233667 0.0095000 9.140474e-01 2.465099e-36 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000149294 E001 0.1817044 0.0399551245 3.719124e-01   11 112961247 112961274 28 + 0.000 0.146 10.198
ENSG00000149294 E002 1.0996539 0.8947635615 9.077896e-01 9.454900e-01 11 112961275 112961367 93 + 0.366 0.257 -0.717
ENSG00000149294 E003 1.8672458 0.2934763833 7.249362e-01 8.183102e-01 11 112961368 112961401 34 + 0.494 0.413 -0.418
ENSG00000149294 E004 2.3853792 0.0082482414 4.566359e-01 5.970249e-01 11 112961402 112961419 18 + 0.563 0.476 -0.415
ENSG00000149294 E005 2.8595053 0.0082089515 4.170376e-01 5.604232e-01 11 112961420 112961424 5 + 0.622 0.530 -0.415
ENSG00000149294 E006 3.0110207 0.0445453069 3.758717e-01 5.202709e-01 11 112961425 112961429 5 + 0.649 0.531 -0.526
ENSG00000149294 E007 3.1561934 0.0353110466 2.877098e-01 4.282284e-01 11 112961430 112961433 4 + 0.674 0.531 -0.634
ENSG00000149294 E008 5.1844934 0.0427852141 1.369893e-01 2.438957e-01 11 112961434 112961434 1 + 0.867 0.662 -0.824
ENSG00000149294 E009 6.8972171 0.0878341960 1.893314e-01 3.128864e-01 11 112961435 112961435 1 + 0.977 0.765 -0.815
ENSG00000149294 E010 8.4409193 0.0707461151 3.351366e-01 4.789021e-01 11 112961436 112961436 1 + 1.023 0.895 -0.477
ENSG00000149294 E011 12.3495155 0.0257917016 2.836624e-01 4.238090e-01 11 112961437 112961438 2 + 1.154 1.073 -0.293
ENSG00000149294 E012 15.7709735 0.0363157709 2.905881e-01 4.314074e-01 11 112961439 112961444 6 + 1.255 1.177 -0.277
ENSG00000149294 E013 20.2215387 0.0366468373 2.140444e-01 3.433129e-01 11 112961445 112961479 35 + 1.362 1.271 -0.319
ENSG00000149294 E014 44.0860358 0.0044375871 1.543936e-03 5.777775e-03 11 112961480 112961660 181 + 1.709 1.563 -0.498
ENSG00000149294 E015 17.3071813 0.0010207688 1.049796e-02 2.997404e-02 11 112961661 112961664 4 + 1.326 1.163 -0.576
ENSG00000149294 E016 0.0000000       11 113003846 113003856 11 +      
ENSG00000149294 E017 0.0000000       11 113040926 113041216 291 +      
ENSG00000149294 E018 0.0000000       11 113130694 113130799 106 +      
ENSG00000149294 E019 0.0000000       11 113132928 113133434 507 +      
ENSG00000149294 E020 0.0000000       11 113133435 113133448 14 +      
ENSG00000149294 E021 0.0000000       11 113133449 113133951 503 +      
ENSG00000149294 E022 17.5265502 0.0010273654 1.495987e-02 4.039484e-02 11 113202379 113202385 7 + 1.326 1.175 -0.534
ENSG00000149294 E023 33.8076370 0.0055390946 1.201931e-05 7.839634e-05 11 113202386 113202453 68 + 1.638 1.375 -0.904
ENSG00000149294 E024 79.2502656 0.0003050004 6.630867e-14 1.931720e-12 11 113204286 113204504 219 + 1.999 1.742 -0.868
ENSG00000149294 E025 76.5377800 0.0003732271 4.535231e-07 4.044941e-06 11 113205523 113205666 144 + 1.953 1.798 -0.524
ENSG00000149294 E026 81.7478711 0.0013644003 1.589269e-04 7.870199e-04 11 113206043 113206180 138 + 1.961 1.852 -0.366
ENSG00000149294 E027 70.5131359 0.0004044214 1.173659e-04 6.017811e-04 11 113207261 113207378 118 + 1.897 1.784 -0.381
ENSG00000149294 E028 96.2258297 0.0002802075 1.178417e-04 6.039440e-04 11 113207833 113208002 170 + 2.022 1.934 -0.296
ENSG00000149294 E029 82.5037453 0.0012923428 1.497852e-03 5.629226e-03 11 113214369 113214511 143 + 1.953 1.871 -0.275
ENSG00000149294 E030 13.1250236 0.0634461872 7.194895e-01 8.143114e-01 11 113221296 113221325 30 + 1.139 1.154 0.055
ENSG00000149294 E031 3.5940637 0.0535088122 9.858405e-01 9.951701e-01 11 113221326 113221903 578 + 0.649 0.694 0.188
ENSG00000149294 E032 1.6940717 0.0083612096 2.850763e-01 4.253881e-01 11 113231196 113231273 78 + 0.315 0.530 1.170
ENSG00000149294 E033 1.6962618 0.0083237218 2.851374e-01 4.254424e-01 11 113231380 113231644 265 + 0.315 0.530 1.170
ENSG00000149294 E034 72.5685232 0.0044762637 3.087896e-01 4.510606e-01 11 113231645 113231795 151 + 1.863 1.863 -0.003
ENSG00000149294 E035 58.0553233 0.0015458899 4.018213e-01 5.455186e-01 11 113232170 113232261 92 + 1.762 1.773 0.034
ENSG00000149294 E036 52.9644962 0.0009342454 5.025415e-01 6.385867e-01 11 113232262 113232324 63 + 1.721 1.739 0.062
ENSG00000149294 E037 42.8397449 0.0011523246 5.296151e-01 6.623711e-01 11 113232325 113232354 30 + 1.628 1.644 0.055
ENSG00000149294 E038 61.5668877 0.0006545528 5.516323e-02 1.182760e-01 11 113232718 113232792 75 + 1.806 1.769 -0.124
ENSG00000149294 E039 36.3429859 0.0006011415 9.331970e-03 2.711358e-02 11 113232793 113232794 2 + 1.609 1.506 -0.349
ENSG00000149294 E040 41.9175306 0.0005334190 5.138494e-03 1.630498e-02 11 113232795 113232814 20 + 1.669 1.567 -0.350
ENSG00000149294 E041 77.3153677 0.0018405849 3.404642e-03 1.145179e-02 11 113233147 113233257 111 + 1.921 1.841 -0.271
ENSG00000149294 E042 60.0189442 0.0004353998 5.987903e-02 1.264082e-01 11 113233258 113233317 60 + 1.795 1.760 -0.117
ENSG00000149294 E043 77.4169599 0.0004782786 1.123674e-02 3.173096e-02 11 113235033 113235164 132 + 1.911 1.859 -0.175
ENSG00000149294 E044 0.5911862 0.0183727384 6.923384e-02 1.421003e-01 11 113236301 113236315 15 + 0.315 0.000 -14.901
ENSG00000149294 E045 0.5932625 0.1452517753 9.520731e-02 1.831885e-01 11 113240507 113240785 279 + 0.315 0.000 -14.034
ENSG00000149294 E046 0.8126314 0.0139271892 2.855459e-01 4.258843e-01 11 113240786 113240833 48 + 0.315 0.146 -1.414
ENSG00000149294 E047 0.2966881 0.0272388083 2.900849e-01   11 113242805 113242846 42 + 0.185 0.000 -13.817
ENSG00000149294 E048 1.6724036 0.1769429562 5.481553e-01 6.780299e-01 11 113243552 113243790 239 + 0.457 0.347 -0.608
ENSG00000149294 E049 1.5092494 0.0091320969 2.320756e-02 5.817767e-02 11 113246108 113246367 260 + 0.530 0.146 -2.585
ENSG00000149294 E050 38.7792592 0.0005922914 1.798107e-02 4.709236e-02 11 113246368 113246370 3 + 1.631 1.547 -0.284
ENSG00000149294 E051 0.4031496 0.0253889617 1.328530e-01 2.380730e-01 11 113255874 113255876 3 + 0.000 0.255 13.711
ENSG00000149294 E052 55.1721595 0.0004521579 5.405135e-02 1.163489e-01 11 113255877 113255949 73 + 1.768 1.729 -0.134
ENSG00000149294 E053 45.7284847 0.0116672154 2.676667e-01 4.060005e-01 11 113255950 113256001 52 + 1.684 1.658 -0.086
ENSG00000149294 E054 0.0000000       11 113260091 113260142 52 +      
ENSG00000149294 E055 4.6886345 0.0034550634 4.881910e-01 6.257934e-01 11 113260143 113260145 3 + 0.782 0.731 -0.205
ENSG00000149294 E056 40.6368365 0.0157958985 5.214327e-01 6.553122e-01 11 113260146 113260180 35 + 1.620 1.623 0.013
ENSG00000149294 E057 81.3260889 0.0013556175 1.671947e-02 4.431988e-02 11 113260181 113260323 143 + 1.936 1.887 -0.165
ENSG00000149294 E058 0.1515154 0.0433197836 6.332271e-01   11 113260324 113260387 64 + 0.102 0.000 -12.653
ENSG00000149294 E059 1.2931122 0.0103315304 6.933954e-01 7.944317e-01 11 113262846 113262902 57 + 0.315 0.414 0.584
ENSG00000149294 E060 11.4803764 0.0016173408 9.264405e-08 9.464081e-07 11 113262903 113265197 2295 + 0.720 1.321 2.229
ENSG00000149294 E061 1.6198755 0.0089745979 6.590169e-01 7.679632e-01 11 113269969 113270187 219 + 0.367 0.476 0.584
ENSG00000149294 E062 95.4521634 0.0012507948 2.177713e-02 5.521208e-02 11 113270188 113270395 208 + 1.999 1.961 -0.128
ENSG00000149294 E063 77.7101935 0.0009714067 9.001693e-02 1.751640e-01 11 113271760 113271876 117 + 1.898 1.879 -0.067
ENSG00000149294 E064 2.7753803 0.0117949279 1.058088e-01 1.993257e-01 11 113272933 113273048 116 + 0.649 0.415 -1.113
ENSG00000149294 E065 6.2258908 0.0026460910 3.894091e-01 5.335060e-01 11 113273049 113273748 700 + 0.782 0.933 0.584
ENSG00000149294 E066 83.9847247 0.0003759356 2.150998e-01 3.445595e-01 11 113275267 113275390 124 + 1.924 1.928 0.013
ENSG00000149294 E067 437.6861406 0.0024648936 1.895664e-03 6.900862e-03 11 113275391 113276716 1326 + 2.575 2.709 0.445
ENSG00000149294 E068 400.7103525 0.0042144194 5.143599e-18 2.604060e-16 11 113276717 113277981 1265 + 2.420 2.756 1.118
ENSG00000149294 E069 154.0988660 0.0081994612 7.047706e-19 3.957222e-17 11 113277982 113278441 460 + 1.883 2.401 1.734