ENSG00000149262

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000529807 ENSG00000149262 HEK293_OSMI2_2hA HEK293_TMG_2hB INTS4 protein_coding protein_coding 14.65037 13.43451 14.95753 1.229238 0.1221476 0.154819 0.9352726 0.2638978 1.536767 0.09409263 0.2901818 2.49754623 0.05977500 0.01866667 0.10306667 0.084400000 0.000665351 2.646032e-07 FALSE  
ENST00000533180 ENSG00000149262 HEK293_OSMI2_2hA HEK293_TMG_2hB INTS4 protein_coding retained_intron 14.65037 13.43451 14.95753 1.229238 0.1221476 0.154819 1.0633562 0.9281147 1.186601 0.52397850 0.5963450 0.35110646 0.07038333 0.07730000 0.07866667 0.001366667 1.000000000 2.646032e-07 FALSE  
ENST00000534064 ENSG00000149262 HEK293_OSMI2_2hA HEK293_TMG_2hB INTS4 protein_coding protein_coding 14.65037 13.43451 14.95753 1.229238 0.1221476 0.154819 10.1684406 9.5479451 9.747510 1.66518722 0.2200212 0.02981258 0.69515000 0.69963333 0.65200000 -0.047633333 0.772410786 2.646032e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000149262 E001 0.6696487 0.0296181476 2.665142e-01 4.047222e-01 11 77874306 77874417 112 - 0.307 0.117 -1.731
ENSG00000149262 E002 0.3729606 0.0434990441 9.399920e-01 9.663220e-01 11 77874418 77874490 73 - 0.128 0.117 -0.145
ENSG00000149262 E003 0.5944058 0.5658575281 7.227834e-01 8.168247e-01 11 77874491 77874493 3 - 0.128 0.219 0.935
ENSG00000149262 E004 6.2244999 0.0078750755 7.388409e-03 2.222753e-02 11 77874494 77876542 2049 - 1.011 0.673 -1.318
ENSG00000149262 E005 1.5103041 0.0101922769 8.873238e-01 9.319951e-01 11 77876543 77877030 488 - 0.375 0.406 0.174
ENSG00000149262 E006 1.1050782 0.0175862814 5.889048e-01 7.120371e-01 11 77877760 77878417 658 - 0.375 0.285 -0.565
ENSG00000149262 E007 0.7718438 0.2001366095 3.883177e-01 5.324130e-01 11 77878418 77878719 302 - 0.128 0.291 1.475
ENSG00000149262 E008 0.7697675 0.2030681833 3.900819e-01 5.341050e-01 11 77878720 77878721 2 - 0.128 0.291 1.477
ENSG00000149262 E009 10.4967316 0.0080908749 2.140618e-01 3.433286e-01 11 77878722 77878748 27 - 0.965 1.106 0.517
ENSG00000149262 E010 12.6271751 0.0016707263 3.644723e-02 8.443382e-02 11 77878749 77878759 11 - 0.996 1.208 0.765
ENSG00000149262 E011 18.1700005 0.0010275891 2.196536e-03 7.831360e-03 11 77878760 77878782 23 - 1.114 1.378 0.930
ENSG00000149262 E012 35.8626133 0.0025571243 1.495329e-05 9.547880e-05 11 77878783 77878844 62 - 1.379 1.669 0.991
ENSG00000149262 E013 135.6103996 0.0095056850 2.314379e-06 1.775757e-05 11 77878845 77879125 281 - 1.956 2.235 0.933
ENSG00000149262 E014 47.6571284 0.0080620118 8.581595e-03 2.524154e-02 11 77879126 77879127 2 - 1.572 1.767 0.663
ENSG00000149262 E015 106.2290239 0.0010992307 1.584324e-09 2.264052e-08 11 77883832 77883952 121 - 1.883 2.122 0.803
ENSG00000149262 E016 1.2564668 0.0118220306 3.776167e-01 5.219352e-01 11 77890964 77891318 355 - 0.433 0.285 -0.887
ENSG00000149262 E017 131.4801758 0.0033115419 1.113708e-04 5.740408e-04 11 77891319 77891462 144 - 2.022 2.185 0.545
ENSG00000149262 E018 115.2148319 0.0012430716 1.028394e-04 5.351925e-04 11 77891681 77891809 129 - 1.974 2.124 0.503
ENSG00000149262 E019 56.8699695 0.0013615188 6.624056e-03 2.024992e-02 11 77891810 77891840 31 - 1.674 1.818 0.486
ENSG00000149262 E020 58.3759230 0.0127898801 8.928747e-03 2.610055e-02 11 77894290 77894349 60 - 1.655 1.839 0.621
ENSG00000149262 E021 0.3332198 0.0304106230 9.352534e-01   11 77894350 77894726 377 - 0.128 0.117 -0.149
ENSG00000149262 E022 0.0000000       11 77894727 77895008 282 -      
ENSG00000149262 E023 0.1482932 0.0411597534 5.380203e-01   11 77895009 77895515 507 - 0.000 0.117 10.262
ENSG00000149262 E024 0.2214452 0.0677230278 5.325371e-01   11 77901357 77901420 64 - 0.000 0.117 10.273
ENSG00000149262 E025 110.5148024 0.0017222771 6.162864e-02 1.293626e-01 11 77901421 77901551 131 - 2.000 2.079 0.264
ENSG00000149262 E026 93.3652297 0.0039823289 6.609928e-01 7.695622e-01 11 77903540 77903620 81 - 1.959 1.988 0.095
ENSG00000149262 E027 96.8829147 0.0115958403 6.156614e-01 7.338732e-01 11 77907717 77907810 94 - 1.970 2.005 0.116
ENSG00000149262 E028 4.7062383 0.0282857265 1.584948e-01 2.731085e-01 11 77910970 77911152 183 - 0.855 0.645 -0.852
ENSG00000149262 E029 0.2934659 0.0285991412 9.317992e-01   11 77917910 77918030 121 - 0.128 0.117 -0.151
ENSG00000149262 E030 0.5149111 0.0206811835 6.435310e-01 7.560481e-01 11 77918031 77918059 29 - 0.128 0.209 0.852
ENSG00000149262 E031 1.3985164 0.1851206693 6.346193e-01 7.490470e-01 11 77918060 77918264 205 - 0.307 0.410 0.612
ENSG00000149262 E032 97.4387020 0.0017352484 6.578885e-01 7.671688e-01 11 77918821 77918978 158 - 1.979 2.006 0.091
ENSG00000149262 E033 80.5529551 0.0003714547 1.401124e-02 3.825212e-02 11 77921340 77921473 134 - 1.958 1.874 -0.283
ENSG00000149262 E034 0.4439371 0.0215575896 6.861991e-02 1.410747e-01 11 77922281 77922355 75 - 0.307 0.000 -12.423
ENSG00000149262 E035 46.4699895 0.0004788392 5.416309e-03 1.705936e-02 11 77922356 77922471 116 - 1.747 1.618 -0.438
ENSG00000149262 E036 14.2069181 0.0012705528 6.346579e-02 1.324703e-01 11 77922472 77923367 896 - 1.258 1.105 -0.545
ENSG00000149262 E037 1.2480477 0.0381842113 3.934946e-01 5.373874e-01 11 77924434 77924441 8 - 0.433 0.285 -0.887
ENSG00000149262 E038 5.4229130 0.0031097561 3.821415e-01 5.263676e-01 11 77924442 77924582 141 - 0.855 0.751 -0.411
ENSG00000149262 E039 6.5104031 0.0027831866 2.439192e-02 6.062603e-02 11 77924583 77924667 85 - 1.011 0.751 -0.998
ENSG00000149262 E040 6.0590685 0.0025987370 1.106733e-03 4.325892e-03 11 77924668 77924705 38 - 1.039 0.643 -1.549
ENSG00000149262 E041 4.7294221 0.0034364005 7.091159e-03 2.146587e-02 11 77924706 77924749 44 - 0.931 0.577 -1.440
ENSG00000149262 E042 16.0532747 0.0011716374 2.120984e-01 3.410117e-01 11 77924750 77924779 30 - 1.290 1.199 -0.321
ENSG00000149262 E043 29.4900981 0.0037670306 6.389889e-02 1.331909e-01 11 77924780 77924892 113 - 1.552 1.438 -0.388
ENSG00000149262 E044 59.3416290 0.0230426266 1.690996e-01 2.870144e-01 11 77928342 77928545 204 - 1.830 1.746 -0.283
ENSG00000149262 E045 25.1436148 0.0499470460 8.202308e-01 8.865816e-01 11 77928546 77928547 2 - 1.410 1.432 0.077
ENSG00000149262 E046 88.6894837 0.0038387276 2.911851e-02 7.023253e-02 11 77938651 77938825 175 - 2.005 1.918 -0.293
ENSG00000149262 E047 64.7953014 0.0004732990 4.655305e-04 2.028226e-03 11 77941180 77941251 72 - 1.895 1.755 -0.471
ENSG00000149262 E048 71.4495553 0.0029701305 1.686616e-03 6.240221e-03 11 77955942 77956062 121 - 1.936 1.796 -0.474
ENSG00000149262 E049 52.5920081 0.0076152183 2.328889e-02 5.835220e-02 11 77958746 77958834 89 - 1.802 1.670 -0.448
ENSG00000149262 E050 44.7616307 0.0010814414 1.139760e-04 5.860336e-04 11 77960341 77960391 51 - 1.760 1.566 -0.659
ENSG00000149262 E051 90.3969372 0.0036945569 9.945681e-06 6.613709e-05 11 77960953 77961138 186 - 2.061 1.863 -0.665
ENSG00000149262 E052 0.3634088 0.3506197084 3.141389e-01   11 77977586 77977888 303 - 0.000 0.210 11.276
ENSG00000149262 E053 1.8874068 0.0124227185 5.237649e-02 1.133922e-01 11 77977889 77978928 1040 - 0.611 0.285 -1.734
ENSG00000149262 E054 0.4470576 0.0211325156 4.981694e-01 6.346738e-01 11 77978929 77978995 67 - 0.227 0.117 -1.151
ENSG00000149262 E055 72.4218227 0.0022823077 2.983704e-05 1.776745e-04 11 77978996 77979100 105 - 1.961 1.779 -0.614
ENSG00000149262 E056 38.4508769 0.0005675707 4.374978e-03 1.419100e-02 11 77979101 77979102 2 - 1.678 1.532 -0.496
ENSG00000149262 E057 0.2998086 0.0283415821 9.320943e-01   11 77979103 77979472 370 - 0.128 0.117 -0.152
ENSG00000149262 E058 66.7338780 0.0037620483 2.061031e-03 7.414663e-03 11 77981459 77981576 118 - 1.910 1.760 -0.503
ENSG00000149262 E059 0.4031496 0.0301474356 2.323586e-01 3.652415e-01 11 77984711 77984860 150 - 0.000 0.209 11.269
ENSG00000149262 E060 11.3594342 0.0019666328 1.793088e-02 4.698672e-02 11 77987016 77987528 513 - 0.931 1.182 0.914
ENSG00000149262 E061 7.1168924 0.0027145005 8.164605e-02 1.621308e-01 11 77987529 77987603 75 - 0.763 0.985 0.851
ENSG00000149262 E062 7.4458458 0.0024104821 9.254825e-02 1.791036e-01 11 77987604 77987698 95 - 0.788 0.998 0.802
ENSG00000149262 E063 86.3001010 0.0062782402 6.173702e-03 1.907074e-02 11 77991108 77991299 192 - 2.013 1.871 -0.477
ENSG00000149262 E064 1.4435834 0.0097682294 2.366255e-01 3.702773e-01 11 77992574 77992629 56 - 0.485 0.285 -1.149
ENSG00000149262 E065 48.1551540 0.0050891945 1.230702e-02 3.427155e-02 11 77994590 77994715 126 - 1.765 1.621 -0.490