ENSG00000149256

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000278550 ENSG00000149256 HEK293_OSMI2_2hA HEK293_TMG_2hB TENM4 protein_coding protein_coding 0.7857896 0.7188097 1.053763 0.06933885 0.1323834 0.5455629 0.52148832 0.53643601 0.5565236 0.057981698 0.01037199 0.05208337 0.7229708 0.74440000 0.5416333 -0.20276667 0.14413555 0.01279507 FALSE  
ENST00000531583 ENSG00000149256 HEK293_OSMI2_2hA HEK293_TMG_2hB TENM4 protein_coding processed_transcript 0.7857896 0.7188097 1.053763 0.06933885 0.1323834 0.5455629 0.02205942 0.06707271 0.0000000 0.007821773 0.00000000 -2.94622018 0.0313125 0.09756667 0.0000000 -0.09756667 0.01279507 0.01279507 TRUE  
ENST00000533525 ENSG00000149256 HEK293_OSMI2_2hA HEK293_TMG_2hB TENM4 protein_coding protein_coding 0.7857896 0.7188097 1.053763 0.06933885 0.1323834 0.5455629 0.15490805 0.08883255 0.4387011 0.045284870 0.15161779 2.18269661 0.1590958 0.11260000 0.3959000 0.28330000 0.09988269 0.01279507 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000149256 E001 105.4296258 0.010463287 1.395147e-06 1.122463e-05 11 78652829 78657806 4978 - 1.877 2.129 0.846
ENSG00000149256 E002 5.9059582 0.031191089 1.379329e-01 2.452024e-01 11 78657807 78658054 248 - 0.697 0.951 0.996
ENSG00000149256 E003 20.5542384 0.001734973 2.187788e-01 3.489391e-01 11 78658055 78658816 762 - 1.251 1.384 0.465
ENSG00000149256 E004 7.6662494 0.002264176 3.337828e-01 4.775308e-01 11 78661449 78661591 143 - 0.852 1.000 0.557
ENSG00000149256 E005 27.7452238 0.003758034 7.240009e-01 8.176568e-01 11 78668937 78670551 1615 - 1.416 1.484 0.234
ENSG00000149256 E006 5.2736774 0.003399489 8.908635e-02 1.737332e-01 11 78672033 78672329 297 - 0.871 0.682 -0.753
ENSG00000149256 E007 5.9304383 0.007490878 2.211879e-01 3.518484e-01 11 78676152 78676387 236 - 0.888 0.768 -0.470
ENSG00000149256 E008 5.4991855 0.003162414 9.188827e-01 9.527633e-01 11 78688054 78688226 173 - 0.792 0.816 0.092
ENSG00000149256 E009 17.5143814 0.001245929 7.875355e-01 8.639141e-01 11 78701526 78702403 878 - 1.251 1.271 0.071
ENSG00000149256 E010 4.4494048 0.003774719 3.709811e-01 5.153946e-01 11 78708361 78708515 155 - 0.770 0.682 -0.361
ENSG00000149256 E011 3.2557463 0.050954187 7.252070e-01 8.185427e-01 11 78712482 78712714 233 - 0.640 0.614 -0.112
ENSG00000149256 E012 0.0000000       11 78720370 78720390 21 -      
ENSG00000149256 E013 4.2008765 0.003920335 5.936835e-01 7.160373e-01 11 78722668 78722917 250 - 0.723 0.682 -0.168
ENSG00000149256 E014 3.6055403 0.004589738 2.226328e-01 3.535412e-01 11 78726079 78726222 144 - 0.723 0.577 -0.627
ENSG00000149256 E015 4.2082805 0.003961556 3.848825e-02 8.826179e-02 11 78729376 78729643 268 - 0.833 0.576 -1.070
ENSG00000149256 E016 4.5981825 0.006246938 1.057864e-03 4.159421e-03 11 78732316 78732577 262 - 0.921 0.488 -1.823
ENSG00000149256 E017 2.4378200 0.006366660 4.804814e-02 1.057161e-01 11 78738451 78738570 120 - 0.669 0.377 -1.407
ENSG00000149256 E018 4.0837213 0.005316819 1.398910e-02 3.820209e-02 11 78756805 78757021 217 - 0.852 0.534 -1.337
ENSG00000149256 E019 3.6806589 0.004450691 8.931415e-04 3.590133e-03 11 78770992 78771138 147 - 0.852 0.377 -2.143
ENSG00000149256 E020 0.0000000       11 78778602 78778628 27 -      
ENSG00000149256 E021 4.0817453 0.010593267 7.509446e-03 2.253869e-02 11 78786898 78787083 186 - 0.852 0.489 -1.556
ENSG00000149256 E022 5.0029290 0.005721801 5.495072e-03 1.727384e-02 11 78805292 78805492 201 - 0.921 0.576 -1.406
ENSG00000149256 E023 4.1791237 0.004105864 3.935302e-03 1.296035e-02 11 78812122 78812316 195 - 0.871 0.488 -1.629
ENSG00000149256 E024 1.8111343 0.007834459 1.895731e-02 4.923849e-02 11 78814294 78814395 102 - 0.608 0.228 -2.144
ENSG00000149256 E025 1.5706715 0.080091475 5.915146e-01 7.142791e-01 11 78854104 78854314 211 - 0.452 0.377 -0.406
ENSG00000149256 E026 2.2413644 0.006585604 6.265985e-01 7.425280e-01 11 78855964 78856178 215 - 0.537 0.488 -0.237
ENSG00000149256 E027 2.4399930 0.006943955 5.648197e-01 6.920367e-01 11 78862962 78863132 171 - 0.453 0.577 0.595
ENSG00000149256 E028 1.8090554 0.007946647 7.967638e-01 8.703043e-01 11 78889785 78889865 81 - 0.453 0.436 -0.084
ENSG00000149256 E029 2.0627685 0.007243862 1.786721e-01 2.994826e-01 11 78889866 78889932 67 - 0.574 0.378 -0.991
ENSG00000149256 E030 2.5840223 0.006159600 3.448970e-01 4.889896e-01 11 78889933 78890020 88 - 0.608 0.488 -0.558
ENSG00000149256 E031 1.9563045 0.007482191 5.967722e-01 7.186553e-01 11 78891238 78891336 99 - 0.497 0.436 -0.307
ENSG00000149256 E032 2.2979328 0.008694268 2.038410e-02 5.229406e-02 11 78903268 78903523 256 - 0.669 0.309 -1.822
ENSG00000149256 E033 0.0000000       11 78903806 78903886 81 -      
ENSG00000149256 E034 0.0000000       11 78924456 78924746 291 -      
ENSG00000149256 E035 0.2998086 0.029980622 9.867881e-01   11 78962143 78962219 77 - 0.116 0.129 0.175
ENSG00000149256 E036 0.0000000       11 79014571 79014750 180 -      
ENSG00000149256 E037 0.0000000       11 79021575 79021793 219 -      
ENSG00000149256 E038 0.1482932 0.042905224 4.764941e-01   11 79064599 79064737 139 - 0.000 0.129 10.636
ENSG00000149256 E039 3.0990351 0.005174917 1.198634e-01 2.197874e-01 11 79064738 79065007 270 - 0.697 0.488 -0.936
ENSG00000149256 E040 0.1451727 0.043440783 4.989261e-01   11 79067903 79068456 554 - 0.116 0.000 -10.945
ENSG00000149256 E041 2.4156819 0.029575257 4.900568e-01 6.274108e-01 11 79069722 79069941 220 - 0.574 0.489 -0.403
ENSG00000149256 E042 1.3879229 0.183139864 1.801354e-01 3.013397e-01 11 79069942 79070009 68 - 0.496 0.229 -1.618
ENSG00000149256 E043 0.0000000       11 79076373 79076393 21 -      
ENSG00000149256 E044 0.9482522 0.052882457 4.461058e-01 5.876373e-01 11 79148710 79148729 20 - 0.347 0.229 -0.819
ENSG00000149256 E045 1.0934249 0.128444275 3.218241e-01 4.650851e-01 11 79148730 79148800 71 - 0.402 0.229 -1.136
ENSG00000149256 E046 0.2903454 0.348077081 2.896591e-01   11 79148801 79148806 6 - 0.207 0.000 -11.126
ENSG00000149256 E047 1.7649465 0.028171364 3.613931e-01 5.057757e-01 11 79215808 79215909 102 - 0.347 0.533 0.981
ENSG00000149256 E048 0.5180316 0.031758072 8.105357e-02 1.611925e-01 11 79220980 79221123 144 - 0.000 0.309 12.165
ENSG00000149256 E049 0.0000000       11 79269586 79269673 88 -      
ENSG00000149256 E050 2.2152238 0.008754852 4.434833e-02 9.902011e-02 11 79297488 79297543 56 - 0.283 0.649 1.915
ENSG00000149256 E051 0.0000000       11 79438962 79439200 239 -      
ENSG00000149256 E052 2.6688276 0.009333437 6.582161e-01 7.674132e-01 11 79440509 79441030 522 - 0.574 0.535 -0.183