ENSG00000149231

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000538597 ENSG00000149231 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC82 protein_coding protein_coding 6.326164 1.973455 10.74641 0.6172292 0.9537245 2.439109 0.6899690 0.00000000 1.5744690 0.00000000 0.9308130 7.307856 0.06087083 0.00000000 0.1331333 0.13313333 0.407567389 0.0003864131 FALSE FALSE
ENST00000545264 ENSG00000149231 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC82 protein_coding retained_intron 6.326164 1.973455 10.74641 0.6172292 0.9537245 2.439109 0.2448541 0.00000000 0.5619679 0.00000000 0.0704125 5.837862 0.03920000 0.00000000 0.0521000 0.05210000 0.001726163 0.0003864131   FALSE
ENST00000646818 ENSG00000149231 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC82 protein_coding protein_coding 6.326164 1.973455 10.74641 0.6172292 0.9537245 2.439109 1.9302972 0.78809911 3.2830235 0.15823785 0.2692407 2.044773 0.35692500 0.49476667 0.3060333 -0.18873333 0.617566759 0.0003864131 FALSE TRUE
ENST00000681238 ENSG00000149231 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC82 protein_coding processed_transcript 6.326164 1.973455 10.74641 0.6172292 0.9537245 2.439109 0.1461562 0.43007641 0.0000000 0.43007641 0.0000000 -5.459682 0.04112083 0.13443333 0.0000000 -0.13443333 0.470111698 0.0003864131 FALSE TRUE
MSTRG.6209.28 ENSG00000149231 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC82 protein_coding   6.326164 1.973455 10.74641 0.6172292 0.9537245 2.439109 0.5824599 0.21634676 1.7488303 0.21634676 0.2141797 2.958010 0.05983333 0.06763333 0.1617000 0.09406667 0.339071388 0.0003864131 FALSE TRUE
MSTRG.6209.32 ENSG00000149231 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC82 protein_coding   6.326164 1.973455 10.74641 0.6172292 0.9537245 2.439109 0.7163201 0.01653918 1.3652007 0.01653918 0.2462516 5.695374 0.08114583 0.01340000 0.1273667 0.11396667 0.001465506 0.0003864131 FALSE TRUE
MSTRG.6209.33 ENSG00000149231 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC82 protein_coding   6.326164 1.973455 10.74641 0.6172292 0.9537245 2.439109 0.8024854 0.00000000 0.4618312 0.00000000 0.4618312 5.560199 0.09721667 0.00000000 0.0510000 0.05100000 1.000000000 0.0003864131 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000149231 E001 0.3289534 0.0321241973 2.673308e-01   11 96349241 96352152 2912 - 0.061 0.232 2.231
ENSG00000149231 E002 0.2955422 0.0296936814 2.684707e-01   11 96352153 96352768 616 - 0.061 0.231 2.227
ENSG00000149231 E003 0.3299976 0.0265737373 1.531418e-02   11 96352769 96352772 4 - 0.000 0.382 14.059
ENSG00000149231 E004 0.4782907 0.0254945242 2.583457e-03 9.014739e-03 11 96352773 96352776 4 - 0.000 0.493 14.597
ENSG00000149231 E005 0.6298062 0.0216134486 1.355410e-02 3.720454e-02 11 96352777 96352778 2 - 0.061 0.493 3.811
ENSG00000149231 E006 1.0027668 0.0139901290 9.212415e-03 2.681598e-02 11 96352779 96352780 2 - 0.114 0.582 3.229
ENSG00000149231 E007 1.1479395 0.0110499422 2.134128e-02 5.430691e-02 11 96352781 96352786 6 - 0.162 0.582 2.644
ENSG00000149231 E008 1.2951885 0.0102659678 4.094661e-02 9.278185e-02 11 96352787 96352788 2 - 0.204 0.582 2.229
ENSG00000149231 E009 1.4434817 0.0091721088 1.208239e-02 3.373273e-02 11 96352789 96352804 16 - 0.204 0.655 2.550
ENSG00000149231 E010 25.0134780 0.0250585548 2.784708e-05 1.668684e-04 11 96352805 96353249 445 - 1.197 1.638 1.526
ENSG00000149231 E011 13.6379653 0.0075463751 6.344272e-03 1.951902e-02 11 96353250 96353446 197 - 1.007 1.300 1.049
ENSG00000149231 E012 3.4623567 0.0048229932 1.256028e-02 3.487467e-02 11 96353447 96353447 1 - 0.470 0.866 1.699
ENSG00000149231 E013 14.6271968 0.0012401771 9.476822e-07 7.900007e-06 11 96353448 96353538 91 - 0.960 1.421 1.645
ENSG00000149231 E014 12.1495092 0.0014759749 4.881813e-07 4.325275e-06 11 96353539 96353565 27 - 0.864 1.372 1.838
ENSG00000149231 E015 19.6880254 0.0010776866 9.930491e-06 6.605231e-05 11 96353566 96353645 80 - 1.110 1.486 1.320
ENSG00000149231 E016 23.8064612 0.0047019582 7.500709e-02 1.515428e-01 11 96353646 96353714 69 - 1.258 1.423 0.573
ENSG00000149231 E017 0.6696487 0.0198245264 7.100356e-01 8.072672e-01 11 96353715 96353812 98 - 0.162 0.232 0.647
ENSG00000149231 E018 5.4314076 0.0038820600 4.249053e-03 1.383919e-02 11 96353813 96358248 4436 - 0.603 1.007 1.610
ENSG00000149231 E019 0.6569633 0.4331090770 6.540000e-01 7.643186e-01 11 96358249 96358614 366 - 0.161 0.237 0.694
ENSG00000149231 E020 0.2903454 0.3300978769 1.000000e+00   11 96358615 96358619 5 - 0.114 0.000 -11.215
ENSG00000149231 E021 0.1451727 0.0431573228 1.000000e+00   11 96358620 96358661 42 - 0.061 0.000 -10.827
ENSG00000149231 E022 36.1672110 0.0085572827 2.062457e-01 3.340169e-01 11 96358993 96359097 105 - 1.448 1.563 0.394
ENSG00000149231 E023 25.0289353 0.0008050898 9.626458e-01 9.803983e-01 11 96359098 96359178 81 - 1.319 1.331 0.044
ENSG00000149231 E024 3.6373466 0.0044611937 1.847304e-01 3.071280e-01 11 96359179 96359640 462 - 0.634 0.382 -1.230
ENSG00000149231 E025 0.1515154 0.0424947035 1.000000e+00   11 96363128 96363131 4 - 0.061 0.000 -10.830
ENSG00000149231 E026 3.8682576 0.0078181273 3.039035e-02 7.272793e-02 11 96363132 96363856 725 - 0.677 0.232 -2.415
ENSG00000149231 E027 2.6677875 0.0057352355 4.295866e-01 5.722943e-01 11 96363857 96364286 430 - 0.532 0.382 -0.771
ENSG00000149231 E028 0.4470576 0.0216817691 4.971491e-01 6.336983e-01 11 96364287 96364648 362 - 0.114 0.231 1.228
ENSG00000149231 E029 1.7757486 0.0077039612 5.877730e-02 1.245379e-01 11 96364649 96364979 331 - 0.448 0.000 -13.975
ENSG00000149231 E030 34.0183056 0.0007144416 1.948559e-01 3.198225e-01 11 96364980 96365126 147 - 1.424 1.524 0.345
ENSG00000149231 E031 20.9921419 0.0009212815 6.273978e-01 7.432009e-01 11 96365127 96365150 24 - 1.255 1.218 -0.130
ENSG00000149231 E032 34.8080412 0.0006058130 8.917818e-01 9.348980e-01 11 96371013 96371137 125 - 1.457 1.476 0.064
ENSG00000149231 E033 0.0000000       11 96371691 96371772 82 -      
ENSG00000149231 E034 27.8800565 0.0007735514 2.697787e-01 4.083344e-01 11 96373375 96373457 83 - 1.385 1.302 -0.291
ENSG00000149231 E035 15.8893573 0.0011647264 2.231889e-01 3.541987e-01 11 96373458 96373467 10 - 1.162 1.036 -0.454
ENSG00000149231 E036 0.1472490 0.0444613074 1.000000e+00   11 96373468 96373543 76 - 0.061 0.000 -10.822
ENSG00000149231 E037 0.2987644 0.0274312289 1.000000e+00   11 96380539 96380547 9 - 0.114 0.000 -11.808
ENSG00000149231 E038 14.6336614 0.0014248935 5.061692e-03 1.609876e-02 11 96380548 96383268 2721 - 1.038 1.317 0.992
ENSG00000149231 E039 54.0917334 0.0004223452 8.088522e-02 1.609235e-01 11 96383269 96383473 205 - 1.665 1.568 -0.331
ENSG00000149231 E040 0.5503986 0.0206146925 6.275289e-02 1.312890e-01 11 96383474 96383960 487 - 0.061 0.382 3.232
ENSG00000149231 E041 0.0000000       11 96383961 96383961 1 -      
ENSG00000149231 E042 84.4826371 0.0016018312 6.650686e-03 2.031788e-02 11 96383962 96384293 332 - 1.863 1.731 -0.445
ENSG00000149231 E043 20.0046981 0.0074962566 1.506575e-01 2.625675e-01 11 96384294 96384362 69 - 1.262 1.113 -0.531
ENSG00000149231 E044 89.3309457 0.0004559887 1.042526e-04 5.416543e-04 11 96384363 96384761 399 - 1.895 1.714 -0.611
ENSG00000149231 E045 13.1933486 0.0153996357 1.806330e-03 6.619156e-03 11 96384762 96385936 1175 - 1.129 0.656 -1.822
ENSG00000149231 E046 2.4627871 0.0410792072 5.831213e-01 7.073196e-01 11 96385937 96385965 29 - 0.492 0.383 -0.571
ENSG00000149231 E047 3.2065183 0.1023461819 8.306882e-01 8.937962e-01 11 96385966 96386020 55 - 0.532 0.589 0.262
ENSG00000149231 E048 4.0266528 0.0040382959 3.761555e-01 5.205219e-01 11 96386021 96386253 233 - 0.649 0.494 -0.708
ENSG00000149231 E049 22.9060190 0.0055361841 3.277658e-02 7.735961e-02 11 96386254 96386293 40 - 1.325 1.114 -0.747
ENSG00000149231 E050 7.1294093 0.0040322400 5.284004e-04 2.265662e-03 11 96386294 96387139 846 - 0.907 0.232 -3.325
ENSG00000149231 E051 4.0469552 0.0329898821 3.494440e-02 8.154756e-02 11 96387140 96387529 390 - 0.691 0.232 -2.472
ENSG00000149231 E052 22.5242250 0.0008863188 5.652839e-02 1.206457e-01 11 96387530 96387613 84 - 1.312 1.136 -0.622
ENSG00000149231 E053 1.6883258 0.4312735250 7.243663e-01 8.179105e-01 11 96387614 96387653 40 - 0.401 0.233 -1.101
ENSG00000149231 E054 9.7041072 0.0025051651 2.460221e-01 3.812839e-01 11 96387654 96388382 729 - 0.974 0.822 -0.578
ENSG00000149231 E055 5.3617010 0.0029443230 4.660368e-03 1.498638e-02 11 96388383 96388694 312 - 0.797 0.232 -2.899
ENSG00000149231 E056 3.1377489 0.0049330121 7.218574e-02 1.469759e-01 11 96388695 96388829 135 - 0.603 0.232 -2.092
ENSG00000149231 E057 6.4106677 0.0025882386 9.192193e-03 2.676575e-02 11 96388830 96389364 535 - 0.855 0.382 -2.128
ENSG00000149231 E058 7.7975454 0.0022521185 9.558432e-02 1.837683e-01 11 96389365 96389523 159 - 0.906 0.655 -1.003
ENSG00000149231 E059 5.9406943 0.0030896941 2.237131e-03 7.957781e-03 11 96389524 96389843 320 - 0.836 0.232 -3.056
ENSG00000149231 E060 9.1149854 0.0042416421 9.371078e-02 1.809191e-01 11 96389844 96389956 113 - 0.960 0.719 -0.940