ENSG00000149187

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310513 ENSG00000149187 HEK293_OSMI2_2hA HEK293_TMG_2hB CELF1 protein_coding protein_coding 36.09581 34.61407 34.14591 4.328936 0.1258671 -0.01963987 15.014551 18.193844 10.795037 2.1884920 1.0268908 -0.75253910 0.4161667 0.5266333 0.3163000 -0.210333333 0.0001402197 3.465992e-05 FALSE TRUE
ENST00000395290 ENSG00000149187 HEK293_OSMI2_2hA HEK293_TMG_2hB CELF1 protein_coding protein_coding 36.09581 34.61407 34.14591 4.328936 0.1258671 -0.01963987 7.384368 6.609398 6.397198 1.1777902 0.4893793 -0.04700657 0.2005333 0.1891000 0.1874667 -0.001633333 1.0000000000 3.465992e-05 FALSE TRUE
ENST00000687097 ENSG00000149187 HEK293_OSMI2_2hA HEK293_TMG_2hB CELF1 protein_coding protein_coding 36.09581 34.61407 34.14591 4.328936 0.1258671 -0.01963987 7.499747 5.703491 8.125863 0.1991631 0.3733482 0.50992276 0.2085333 0.1697667 0.2379000 0.068133333 0.1612891729 3.465992e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000149187 E001 0.5451131 0.6911040642 2.990081e-01 4.404938e-01 11 47465933 47465936 4 - 0.000 0.313 10.994
ENSG00000149187 E002 7.9217786 0.0022091535 5.063034e-08 5.452346e-07 11 47465937 47465943 7 - 0.402 1.183 3.227
ENSG00000149187 E003 784.9946947 0.0069704737 1.759604e-28 2.595233e-26 11 47465944 47466545 602 - 2.551 3.078 1.755
ENSG00000149187 E004 1773.8387075 0.0011842404 5.764904e-36 1.496087e-33 11 47466546 47468283 1738 - 3.094 3.360 0.884
ENSG00000149187 E005 187.9886378 0.0001890477 7.456043e-06 5.099368e-05 11 47468284 47468392 109 - 2.171 2.365 0.647
ENSG00000149187 E006 453.1700891 0.0024353433 5.155212e-02 1.119088e-01 11 47468393 47468813 421 - 2.591 2.716 0.418
ENSG00000149187 E007 240.4552564 0.0014075062 9.326830e-01 9.616084e-01 11 47468814 47468891 78 - 2.346 2.423 0.256
ENSG00000149187 E008 589.9797547 0.0012716360 8.450867e-01 9.036266e-01 11 47468892 47470293 1402 - 2.738 2.805 0.222
ENSG00000149187 E009 12.6658002 0.0013898009 1.336571e-01 2.392266e-01 11 47470294 47470315 22 - 1.019 1.230 0.761
ENSG00000149187 E010 8.4463630 0.0019802673 7.849844e-02 1.570823e-01 11 47470316 47470317 2 - 0.832 1.096 0.987
ENSG00000149187 E011 9.3696350 0.0020676668 5.748325e-02 1.223159e-01 11 47470318 47470328 11 - 0.869 1.142 1.007
ENSG00000149187 E012 77.6198631 0.0063218123 1.070229e-01 2.011406e-01 11 47470329 47470418 90 - 1.808 1.976 0.564
ENSG00000149187 E013 138.6893875 0.0050791383 1.775699e-01 2.980851e-01 11 47470419 47470555 137 - 2.074 2.214 0.468
ENSG00000149187 E014 229.9641862 0.0019658756 4.732754e-01 6.122560e-01 11 47470556 47470889 334 - 2.316 2.416 0.335
ENSG00000149187 E015 336.4796827 0.0002112686 5.574675e-07 4.888246e-06 11 47470890 47471701 812 - 2.544 2.521 -0.078
ENSG00000149187 E016 158.7903778 0.0070644738 3.869878e-05 2.238039e-04 11 47471702 47471997 296 - 2.270 2.131 -0.464
ENSG00000149187 E017 88.4841455 0.0052334299 2.268265e-04 1.078287e-03 11 47471998 47472102 105 - 2.010 1.892 -0.397
ENSG00000149187 E018 50.2327752 0.0068131675 1.026345e-02 2.941420e-02 11 47472103 47472190 88 - 1.756 1.664 -0.313
ENSG00000149187 E019 242.8272020 0.0016184698 1.942387e-05 1.208789e-04 11 47472191 47472330 140 - 2.417 2.367 -0.167
ENSG00000149187 E020 117.2673151 0.0002926101 1.100621e-05 7.242310e-05 11 47472331 47472357 27 - 2.113 2.046 -0.225
ENSG00000149187 E021 196.5839564 0.0003439768 3.413253e-09 4.584407e-08 11 47473088 47473231 144 - 2.340 2.263 -0.258
ENSG00000149187 E022 143.4267654 0.0026451916 2.501679e-06 1.905882e-05 11 47475336 47475455 120 - 2.215 2.106 -0.364
ENSG00000149187 E023 110.9428371 0.0005341462 2.990875e-08 3.367280e-07 11 47475456 47475521 66 - 2.108 1.991 -0.392
ENSG00000149187 E024 147.8768367 0.0002618703 4.311922e-12 9.529640e-11 11 47476846 47476956 111 - 2.238 2.110 -0.427
ENSG00000149187 E025 35.2215156 0.0053634014 1.271426e-02 3.523985e-02 11 47476957 47476959 3 - 1.608 1.513 -0.326
ENSG00000149187 E026 2.0702586 0.0066967407 4.283594e-03 1.393707e-02 11 47476960 47477060 101 - 0.668 0.229 -2.394
ENSG00000149187 E027 0.6590396 0.0188266996 2.982760e-01 4.397183e-01 11 47477296 47477296 1 - 0.282 0.130 -1.390
ENSG00000149187 E028 144.7109881 0.0003165125 2.376892e-11 4.659992e-10 11 47477297 47477425 129 - 2.226 2.101 -0.417
ENSG00000149187 E029 3.2245143 0.0681211178 5.648933e-02 1.205775e-01 11 47477426 47477683 258 - 0.746 0.441 -1.379
ENSG00000149187 E030 108.4014193 0.0002576462 1.181740e-08 1.437598e-07 11 47478877 47478940 64 - 2.100 1.982 -0.395
ENSG00000149187 E031 47.6574153 0.0087329658 1.464097e-03 5.520107e-03 11 47478941 47478952 12 - 1.758 1.612 -0.496
ENSG00000149187 E032 3.0959161 0.0072945216 5.075798e-03 1.613766e-02 11 47482442 47482694 253 - 0.769 0.379 -1.807
ENSG00000149187 E033 154.5805162 0.0004545711 7.956257e-12 1.682430e-10 11 47482695 47482856 162 - 2.257 2.130 -0.425
ENSG00000149187 E034 131.5051439 0.0002787375 7.087039e-08 7.405506e-07 11 47483453 47483532 80 - 2.172 2.081 -0.305
ENSG00000149187 E035 180.0722525 0.0002381429 1.543346e-15 5.691693e-14 11 47484389 47484520 132 - 2.326 2.188 -0.461
ENSG00000149187 E036 78.2900477 0.0005949478 3.018150e-04 1.386872e-03 11 47484521 47484523 3 - 1.936 1.863 -0.244
ENSG00000149187 E037 103.3417740 0.0003155944 6.642599e-08 6.984628e-07 11 47486750 47486773 24 - 2.075 1.961 -0.382
ENSG00000149187 E038 101.2025973 0.0007361083 2.154577e-09 3.000869e-08 11 47486774 47486798 25 - 2.079 1.932 -0.494
ENSG00000149187 E039 0.4804688 0.0222462113 5.480982e-01 6.779946e-01 11 47486799 47486799 1 - 0.207 0.130 -0.808
ENSG00000149187 E040 101.0781667 0.0016018941 4.112206e-10 6.544398e-09 11 47487159 47487183 25 - 2.091 1.914 -0.595
ENSG00000149187 E041 76.1888363 0.0012041863 1.425054e-09 2.052709e-08 11 47487184 47487191 8 - 1.974 1.784 -0.638
ENSG00000149187 E042 104.0600262 0.0015538664 1.528526e-08 1.820423e-07 11 47487192 47487241 50 - 2.092 1.943 -0.502
ENSG00000149187 E043 69.5310552 0.0065916523 5.156202e-04 2.217793e-03 11 47488837 47488844 8 - 1.913 1.784 -0.435
ENSG00000149187 E044 152.0992281 0.0094108236 3.091441e-06 2.305946e-05 11 47488845 47488971 127 - 2.273 2.083 -0.637
ENSG00000149187 E045 72.8767540 0.0054520420 2.035637e-10 3.407363e-09 11 47488972 47488982 11 - 1.991 1.706 -0.959
ENSG00000149187 E046 92.5703848 0.0063602815 1.257213e-10 2.182890e-09 11 47488983 47489024 42 - 2.092 1.811 -0.944
ENSG00000149187 E047 0.6621601 0.0172671820 9.666338e-01 9.830731e-01 11 47489025 47489025 1 - 0.207 0.229 0.193
ENSG00000149187 E048 0.3030308 0.3702977236 2.843323e-01   11 47493283 47493320 38 - 0.207 0.000 -13.189
ENSG00000149187 E049 1.3683405 0.0100149091 9.558954e-01 9.763388e-01 11 47494331 47494443 113 - 0.346 0.379 0.194
ENSG00000149187 E050 0.1515154 0.0428508699 4.805226e-01   11 47494444 47494521 78 - 0.115 0.000 -13.211
ENSG00000149187 E051 35.3572875 0.0389974660 6.503498e-03 1.993122e-02 11 47499453 47499604 152 - 1.666 1.423 -0.832
ENSG00000149187 E052 0.4741261 0.0222318675 5.487010e-01 6.785321e-01 11 47499605 47499763 159 - 0.207 0.130 -0.807
ENSG00000149187 E053 25.8471255 0.0324983311 3.570641e-05 2.082722e-04 11 47500861 47500905 45 - 1.588 1.194 -1.367
ENSG00000149187 E054 17.8519470 0.0293483783 2.682600e-04 1.250549e-03 11 47500906 47500932 27 - 1.424 1.070 -1.247
ENSG00000149187 E055 1.7190664 0.1681898377 2.046763e-01 3.319851e-01 11 47502967 47503056 90 - 0.535 0.312 -1.211
ENSG00000149187 E056 10.3221248 0.0557007285 1.543239e-02 4.147450e-02 11 47506858 47506897 40 - 1.184 0.882 -1.108
ENSG00000149187 E057 0.0000000       11 47523248 47523599 352 -      
ENSG00000149187 E058 0.0000000       11 47523600 47523988 389 -      
ENSG00000149187 E059 0.0000000       11 47524524 47524781 258 -      
ENSG00000149187 E060 3.5921022 0.0048237070 1.210400e-01 2.214240e-01 11 47536620 47536730 111 - 0.746 0.578 -0.716
ENSG00000149187 E061 64.9857386 0.0148111743 9.387655e-10 1.399233e-08 11 47552992 47553112 121 - 1.979 1.580 -1.349
ENSG00000149187 E062 15.4078825 0.0011690029 1.037907e-14 3.405999e-13 11 47553113 47553153 41 - 1.439 0.769 -2.443
ENSG00000149187 E063 0.3289534 0.0274424043 1.000000e+00   11 47564351 47564469 119 - 0.115 0.130 0.193
ENSG00000149187 E064 1.5048693 0.5688081871 2.086881e-01 3.369280e-01 11 47564842 47564885 44 - 0.572 0.130 -2.963
ENSG00000149187 E065 5.6379309 0.0028869102 1.477006e-01 2.585654e-01 11 47565274 47565569 296 - 0.886 0.768 -0.461