ENSG00000149179

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000278460 ENSG00000149179 HEK293_OSMI2_2hA HEK293_TMG_2hB C11orf49 protein_coding protein_coding 30.28955 47.55219 18.39289 0.8629467 0.6814902 -1.369883 13.346362 21.222999 7.888351 1.9505286 0.1848626 -1.4266848 0.43903333 0.44733333 0.42950000 -0.017833333 0.92766964 0.003892379 FALSE  
ENST00000395460 ENSG00000149179 HEK293_OSMI2_2hA HEK293_TMG_2hB C11orf49 protein_coding protein_coding 30.28955 47.55219 18.39289 0.8629467 0.6814902 -1.369883 2.852074 3.751965 1.274476 0.3041023 0.2086432 -1.5503063 0.09304583 0.07890000 0.07023333 -0.008666667 0.82288502 0.003892379 FALSE  
ENST00000525279 ENSG00000149179 HEK293_OSMI2_2hA HEK293_TMG_2hB C11orf49 protein_coding nonsense_mediated_decay 30.28955 47.55219 18.39289 0.8629467 0.6814902 -1.369883 1.859679 2.474162 1.284694 0.2225006 0.5629375 -0.9401482 0.06193750 0.05213333 0.06786667 0.015733333 0.89849585 0.003892379    
ENST00000525895 ENSG00000149179 HEK293_OSMI2_2hA HEK293_TMG_2hB C11orf49 protein_coding nonsense_mediated_decay 30.28955 47.55219 18.39289 0.8629467 0.6814902 -1.369883 4.507687 7.664923 1.397913 1.3471707 0.1387718 -2.4465936 0.13664167 0.16100000 0.07566667 -0.085333333 0.01791325 0.003892379 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000149179 E001 0.0000000       11 46936689 46936696 8 +      
ENSG00000149179 E002 1.1738620 0.0111607565 8.567387e-01 9.114353e-01 11 46936697 46936729 33 + 0.322 0.293 -0.196
ENSG00000149179 E003 10.4285769 0.0017235892 1.897955e-02 4.928949e-02 11 46936730 46936744 15 + 1.169 0.929 -0.877
ENSG00000149179 E004 22.7183624 0.0008408423 6.985520e-02 1.431368e-01 11 46936745 46936747 3 + 1.402 1.267 -0.470
ENSG00000149179 E005 26.6934495 0.0007496482 4.568935e-02 1.014618e-01 11 46936748 46936753 6 + 1.472 1.334 -0.477
ENSG00000149179 E006 30.8376454 0.0008172455 6.122523e-03 1.892931e-02 11 46936754 46936759 6 + 1.559 1.382 -0.611
ENSG00000149179 E007 31.0193498 0.0007727406 6.997088e-03 2.121569e-02 11 46936760 46936760 1 + 1.559 1.385 -0.599
ENSG00000149179 E008 45.7834365 0.0005156050 5.979504e-03 1.855375e-02 11 46936761 46936767 7 + 1.704 1.556 -0.502
ENSG00000149179 E009 64.0170978 0.0003821721 1.954874e-03 7.086450e-03 11 46936768 46936777 10 + 1.841 1.699 -0.477
ENSG00000149179 E010 68.8110401 0.0003584396 7.217166e-03 2.178882e-02 11 46936778 46936778 1 + 1.854 1.736 -0.399
ENSG00000149179 E011 71.6403895 0.0003594851 1.172392e-02 3.287408e-02 11 46936779 46936779 1 + 1.864 1.756 -0.366
ENSG00000149179 E012 162.6037518 0.0002721572 4.233958e-03 1.379643e-02 11 46936780 46936851 72 + 2.195 2.114 -0.272
ENSG00000149179 E013 1.5123648 0.0241495073 6.135601e-02 1.289160e-01 11 46948026 46948164 139 + 0.000 0.405 13.410
ENSG00000149179 E014 165.7823264 0.0011588628 1.829819e-02 4.778266e-02 11 46987208 46987310 103 + 2.197 2.124 -0.243
ENSG00000149179 E015 0.1472490 0.0425649605 1.609745e-01   11 46987311 46987873 563 + 0.191 0.000 -12.907
ENSG00000149179 E016 1.5187246 0.0107650957 2.329316e-02 5.836136e-02 11 46991543 46991647 105 + 0.634 0.247 -2.105
ENSG00000149179 E017 0.0000000       11 47004365 47004456 92 +      
ENSG00000149179 E018 0.3634088 0.3461113627 7.942297e-01   11 47023339 47023394 56 + 0.000 0.142 10.546
ENSG00000149179 E019 0.1472490 0.0425649605 1.609745e-01   11 47051923 47052207 285 + 0.191 0.000 -12.907
ENSG00000149179 E020 195.0525674 0.0001979682 4.904994e-02 1.074672e-01 11 47052388 47052453 66 + 2.251 2.203 -0.161
ENSG00000149179 E021 137.0178033 0.0002475939 3.026282e-02 7.248221e-02 11 47052454 47052460 7 + 2.113 2.048 -0.219
ENSG00000149179 E022 194.1936137 0.0001971200 6.927943e-01 7.939352e-01 11 47052461 47052518 58 + 2.216 2.213 -0.011
ENSG00000149179 E023 0.1482932 0.0413455022 1.000000e+00   11 47052519 47053002 484 + 0.000 0.076 10.300
ENSG00000149179 E024 0.8469850 0.0144251138 7.810455e-01 8.593203e-01 11 47103702 47103811 110 + 0.191 0.248 0.482
ENSG00000149179 E025 0.6172225 0.4060081871 1.512104e-01 2.633277e-01 11 47109054 47109318 265 + 0.422 0.077 -3.088
ENSG00000149179 E026 5.4760283 0.0130177691 8.112088e-02 1.612942e-01 11 47137316 47137560 245 + 0.912 0.669 -0.965
ENSG00000149179 E027 168.8499467 0.0002062940 9.167142e-03 2.670143e-02 11 47137645 47137695 51 + 2.079 2.172 0.310
ENSG00000149179 E028 158.0189521 0.0002220463 4.360035e-03 1.414764e-02 11 47137696 47137729 34 + 2.039 2.144 0.350
ENSG00000149179 E029 7.1491839 0.0031160537 4.372610e-01 5.792472e-01 11 47137730 47138037 308 + 0.912 0.818 -0.360
ENSG00000149179 E030 0.4741261 0.0221442565 1.388971e-01 2.465809e-01 11 47154395 47154471 77 + 0.322 0.076 -2.517
ENSG00000149179 E031 0.6599951 0.0178832792 2.683648e-01 4.068184e-01 11 47154944 47154984 41 + 0.000 0.247 12.518
ENSG00000149179 E032 0.7331471 0.0172671820 2.662509e-01 4.044250e-01 11 47155156 47155175 20 + 0.000 0.248 12.528
ENSG00000149179 E033 184.6553758 0.0001958022 3.207366e-03 1.087688e-02 11 47155176 47155261 86 + 2.112 2.211 0.334
ENSG00000149179 E034 1.8561832 0.0463310033 1.821443e-01 3.038923e-01 11 47155596 47155952 357 + 0.575 0.334 -1.253
ENSG00000149179 E035 285.4042996 0.0002059584 3.129651e-02 7.447760e-02 11 47157023 47157218 196 + 2.331 2.392 0.203
ENSG00000149179 E036 239.6850191 0.0001842572 4.305476e-01 5.731850e-01 11 47157813 47157922 110 + 2.314 2.301 -0.042
ENSG00000149179 E037 1.1404508 0.0117426002 8.549487e-01 9.102897e-01 11 47157923 47157979 57 + 0.322 0.292 -0.197
ENSG00000149179 E038 9.6752756 0.0275765622 8.515047e-01 9.079269e-01 11 47159633 47159811 179 + 0.940 0.972 0.122
ENSG00000149179 E039 11.3486030 0.0017033728 5.032581e-02 1.097447e-01 11 47160105 47161126 1022 + 0.813 1.064 0.942
ENSG00000149179 E040 180.8575370 0.0001941146 7.589592e-01 8.434280e-01 11 47161127 47161190 64 + 2.169 2.186 0.058
ENSG00000149179 E041 45.6890334 0.0029835321 8.838480e-01 9.297292e-01 11 47161191 47161445 255 + 1.597 1.597 -0.001
ENSG00000149179 E042 24.6065637 0.0008263289 1.925781e-01 3.169956e-01 11 47161446 47161463 18 + 1.244 1.360 0.408
ENSG00000149179 E043 585.7725263 0.0015828443 4.737305e-06 3.390944e-05 11 47161464 47162247 784 + 2.599 2.714 0.381
ENSG00000149179 E044 9.0745518 0.0034573951 3.867624e-01 5.309414e-01 11 47164093 47164385 293 + 0.849 0.967 0.447