ENSG00000149136

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000278412 ENSG00000149136 HEK293_OSMI2_2hA HEK293_TMG_2hB SSRP1 protein_coding protein_coding 392.3231 575.6477 287.603 15.04891 3.865743 -1.001082 340.76022 478.7619 268.76858 23.043178 3.052016 -0.8329203 0.87997917 0.8308333 0.93480000 0.1039667 0.01409901 1.034292e-12 FALSE TRUE
ENST00000635721 ENSG00000149136 HEK293_OSMI2_2hA HEK293_TMG_2hB SSRP1 protein_coding protein_coding 392.3231 575.6477 287.603 15.04891 3.865743 -1.001082 42.42718 83.3342 11.84564 6.865425 4.318853 -2.8135088 0.09697083 0.1453000 0.04093333 -0.1043667 0.04443754 1.034292e-12 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000149136 E001 2.9795168 0.0184267179 7.850105e-03 2.340613e-02 11 57325986 57325986 1 - 0.166 0.685 3.038
ENSG00000149136 E002 4.4575280 0.0037373964 5.399667e-02 1.162591e-01 11 57325987 57325987 1 - 0.457 0.778 1.421
ENSG00000149136 E003 56.9397777 0.0043386049 5.645553e-19 3.202195e-17 11 57325988 57325999 12 - 1.148 1.839 2.383
ENSG00000149136 E004 327.2829785 0.0074454268 4.588636e-06 3.294937e-05 11 57326000 57326028 29 - 2.290 2.532 0.807
ENSG00000149136 E005 6623.9067387 0.0027666860 3.296931e-11 6.304570e-10 11 57326029 57326478 450 - 3.645 3.822 0.588
ENSG00000149136 E006 4838.9876293 0.0005037170 1.010743e-29 1.663616e-27 11 57326703 57326871 169 - 3.532 3.679 0.489
ENSG00000149136 E007 2155.9952332 0.0011274740 1.166038e-11 2.400592e-10 11 57326872 57326889 18 - 3.190 3.326 0.451
ENSG00000149136 E008 28.6733698 0.0052864202 2.557805e-03 8.935432e-03 11 57326890 57327425 536 - 1.567 1.355 -0.731
ENSG00000149136 E009 3872.4906119 0.0009648653 3.454554e-10 5.563201e-09 11 57327426 57327511 86 - 3.463 3.574 0.369
ENSG00000149136 E010 2144.2783043 0.0007898773 2.348457e-03 8.302229e-03 11 57327512 57327514 3 - 3.245 3.305 0.196
ENSG00000149136 E011 4956.6218707 0.0009343568 1.810142e-05 1.134210e-04 11 57327712 57327882 171 - 3.597 3.672 0.251
ENSG00000149136 E012 10.9805863 0.0122676230 3.705686e-01 5.149914e-01 11 57328221 57328296 76 - 1.103 1.013 -0.328
ENSG00000149136 E013 1815.3366444 0.0003337284 3.989847e-05 2.300327e-04 11 57328297 57328302 6 - 3.170 3.234 0.212
ENSG00000149136 E014 4184.5546501 0.0007240187 6.945140e-05 3.773910e-04 11 57328303 57328426 124 - 3.530 3.597 0.222
ENSG00000149136 E015 24.6660336 0.0215011977 5.070035e-07 4.480585e-06 11 57328427 57328643 217 - 1.647 1.166 -1.668
ENSG00000149136 E016 87.5706760 0.0039719416 1.159517e-36 3.211507e-34 11 57328644 57330092 1449 - 2.239 1.633 -2.037
ENSG00000149136 E017 3089.9356454 0.0008705590 2.097714e-02 5.354139e-02 11 57330093 57330138 46 - 3.413 3.461 0.159
ENSG00000149136 E018 5116.0192331 0.0004463550 6.403768e-01 7.536263e-01 11 57330291 57330429 139 - 3.654 3.671 0.054
ENSG00000149136 E019 16.5680690 0.0292736584 1.543509e-03 5.776633e-03 11 57330430 57330732 303 - 1.419 1.063 -1.256
ENSG00000149136 E020 8.7227948 0.0267133145 1.824097e-03 6.676902e-03 11 57330733 57330741 9 - 1.189 0.794 -1.469
ENSG00000149136 E021 20.1436918 0.0009519266 1.306756e-04 6.617509e-04 11 57330742 57330854 113 - 1.462 1.179 -0.990
ENSG00000149136 E022 3762.9783260 0.0000703388 3.844773e-03 1.270638e-02 11 57330855 57330927 73 - 3.540 3.531 -0.031
ENSG00000149136 E023 5014.0637619 0.0002397760 2.225825e-04 1.060233e-03 11 57331668 57331889 222 - 3.673 3.651 -0.074
ENSG00000149136 E024 3619.2995361 0.0005754784 1.681487e-02 4.452542e-02 11 57332152 57332280 129 - 3.530 3.509 -0.068
ENSG00000149136 E025 2345.8212460 0.0011824785 4.600069e-04 2.006514e-03 11 57332383 57332444 62 - 3.365 3.311 -0.179
ENSG00000149136 E026 2170.7754838 0.0017399569 6.525181e-05 3.571421e-04 11 57332445 57332486 42 - 3.347 3.270 -0.256
ENSG00000149136 E027 3636.9675138 0.0013194344 4.166570e-06 3.016794e-05 11 57332625 57332834 210 - 3.569 3.495 -0.246
ENSG00000149136 E028 1298.5104202 0.0032391257 2.599302e-03 9.062850e-03 11 57332835 57332855 21 - 3.126 3.046 -0.264
ENSG00000149136 E029 24.7494971 0.0112182473 4.813463e-10 7.556315e-09 11 57332856 57332958 103 - 1.665 1.146 -1.802
ENSG00000149136 E030 3254.4012207 0.0020334385 6.903935e-03 2.097554e-02 11 57332959 57333144 186 - 3.505 3.454 -0.169
ENSG00000149136 E031 1405.3358198 0.0041024667 1.775975e-01 2.981155e-01 11 57333145 57333149 5 - 3.129 3.094 -0.114
ENSG00000149136 E032 44.7076901 0.0065338292 6.256630e-26 7.440676e-24 11 57333150 57333434 285 - 1.979 1.297 -2.324
ENSG00000149136 E033 1440.5749563 0.0004154173 9.413370e-18 4.644101e-16 11 57333435 57333437 3 - 3.190 3.083 -0.359
ENSG00000149136 E034 2768.2130830 0.0019816859 1.547893e-04 7.682773e-04 11 57333438 57333540 103 - 3.451 3.376 -0.250
ENSG00000149136 E035 3370.4835728 0.0014023885 1.628690e-10 2.772241e-09 11 57334463 57334648 186 - 3.560 3.450 -0.367
ENSG00000149136 E036 1864.0326819 0.0009073693 1.792489e-27 2.427317e-25 11 57335068 57335160 93 - 3.343 3.171 -0.573
ENSG00000149136 E037 1235.8329529 0.0027979961 7.545055e-12 1.602273e-10 11 57335161 57335240 80 - 3.169 2.989 -0.600
ENSG00000149136 E038 84.2074508 0.0046436239 1.070161e-08 1.312310e-07 11 57335241 57335281 41 - 2.067 1.786 -0.944
ENSG00000149136 E039 57.5686890 0.0145566038 9.687406e-06 6.462122e-05 11 57335282 57335722 441 - 1.924 1.602 -1.091
ENSG00000149136 E040 1.1835302 0.1037010798 4.062459e-03 1.331685e-02 11 57335723 57335725 3 - 0.630 0.088 -3.853
ENSG00000149136 E041 0.8868421 0.0381300978 1.241304e-02 3.453176e-02 11 57335726 57335729 4 - 0.523 0.089 -3.362
ENSG00000149136 E042 496.3852995 0.0046021232 3.342155e-07 3.062004e-06 11 57335730 57336008 279 - 2.773 2.594 -0.599