ENSG00000149115

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358252 ENSG00000149115 HEK293_OSMI2_2hA HEK293_TMG_2hB TNKS1BP1 protein_coding protein_coding 22.84115 34.30801 13.3898 1.71956 0.4116865 -1.356755 13.142692 16.407830 10.4824014 1.4315181 0.18637487 -0.6459185 0.6228375 0.47763333 0.78346667 0.3058333 1.966844e-10 1.966844e-10 FALSE TRUE
ENST00000427750 ENSG00000149115 HEK293_OSMI2_2hA HEK293_TMG_2hB TNKS1BP1 protein_coding retained_intron 22.84115 34.30801 13.3898 1.71956 0.4116865 -1.356755 1.918488 2.488583 0.7734706 0.2046242 0.06277128 -1.6731591 0.0814875 0.07253333 0.05803333 -0.0145000 5.240294e-01 1.966844e-10 FALSE TRUE
MSTRG.5503.6 ENSG00000149115 HEK293_OSMI2_2hA HEK293_TMG_2hB TNKS1BP1 protein_coding   22.84115 34.30801 13.3898 1.71956 0.4116865 -1.356755 6.752285 13.415166 1.8657667 0.8020830 0.28758029 -2.8393877 0.2540375 0.39310000 0.13830000 -0.2548000 5.280889e-07 1.966844e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000149115 E001 1.8338572 0.0089009703 4.151202e-01 5.585381e-01 11 57299638 57299641 4 - 0.305 0.458 0.881
ENSG00000149115 E002 2.9033315 0.0053135336 9.199979e-02 1.782334e-01 11 57299642 57299643 2 - 0.305 0.615 1.618
ENSG00000149115 E003 17.4951116 0.0015257197 5.452498e-01 6.756358e-01 11 57299644 57299675 32 - 1.168 1.226 0.205
ENSG00000149115 E004 218.2969940 0.0054799531 1.037241e-02 2.967774e-02 11 57299676 57299961 286 - 2.186 2.309 0.410
ENSG00000149115 E005 211.0330405 0.0095425941 1.229851e-02 3.424988e-02 11 57299962 57300081 120 - 2.152 2.299 0.492
ENSG00000149115 E006 185.7376824 0.0078664454 9.937770e-04 3.937098e-03 11 57300528 57300600 73 - 2.068 2.251 0.613
ENSG00000149115 E007 4.1493901 0.0042504834 9.847298e-01 9.945118e-01 11 57300601 57300679 79 - 0.659 0.657 -0.006
ENSG00000149115 E008 281.2806815 0.0020410848 3.888903e-06 2.836347e-05 11 57300884 57301041 158 - 2.268 2.424 0.519
ENSG00000149115 E009 252.3915304 0.0002089867 1.425204e-05 9.133985e-05 11 57301807 57301943 137 - 2.250 2.367 0.388
ENSG00000149115 E010 265.7308417 0.0014120261 1.090364e-02 3.093002e-02 11 57302074 57302224 151 - 2.300 2.380 0.268
ENSG00000149115 E011 322.3195908 0.0002244469 2.968424e-07 2.749787e-06 11 57302459 57302825 367 - 2.353 2.475 0.408
ENSG00000149115 E012 34.0246587 0.0006276450 9.222438e-01 9.549501e-01 11 57302826 57303479 654 - 1.477 1.485 0.030
ENSG00000149115 E013 398.8014635 0.0001993248 5.302568e-04 2.272647e-03 11 57308395 57308890 496 - 2.484 2.557 0.245
ENSG00000149115 E014 764.6305299 0.0001446729 2.944942e-01 4.355781e-01 11 57308891 57309831 941 - 2.808 2.825 0.057
ENSG00000149115 E015 240.0034420 0.0002307808 3.976186e-02 9.058377e-02 11 57309832 57309988 157 - 2.355 2.304 -0.167
ENSG00000149115 E016 392.0295360 0.0032729803 4.863970e-03 1.555214e-02 11 57309989 57310556 568 - 2.593 2.508 -0.281
ENSG00000149115 E017 0.7373885 0.4356344979 5.135325e-01 6.483435e-01 11 57311238 57311484 247 - 0.304 0.158 -1.213
ENSG00000149115 E018 7.5730925 0.1005214513 7.124356e-01 8.091770e-01 11 57311485 57311497 13 - 0.818 0.886 0.264
ENSG00000149115 E019 258.4973117 0.0002183218 2.568301e-06 1.952162e-05 11 57312534 57312935 402 - 2.430 2.319 -0.369
ENSG00000149115 E020 265.1492121 0.0013852884 9.629043e-07 8.015261e-06 11 57312936 57313508 573 - 2.458 2.322 -0.454
ENSG00000149115 E021 175.9383603 0.0045225073 2.327766e-02 5.832638e-02 11 57313509 57313889 381 - 2.251 2.158 -0.310
ENSG00000149115 E022 73.2725082 0.0072635311 1.712746e-02 4.522231e-02 11 57317818 57317887 70 - 1.908 1.769 -0.469
ENSG00000149115 E023 0.5514428 0.0196943652 3.322919e-01 4.759277e-01 11 57320065 57320078 14 - 0.000 0.211 10.545
ENSG00000149115 E024 167.5184476 0.0020400319 6.024852e-07 5.246465e-06 11 57320079 57320376 298 - 2.285 2.111 -0.582
ENSG00000149115 E025 169.7430626 0.0002187064 1.194080e-12 2.894625e-11 11 57320377 57320712 336 - 2.309 2.108 -0.674
ENSG00000149115 E026 82.1241979 0.0017669221 3.765227e-05 2.184586e-04 11 57321792 57321950 159 - 1.983 1.799 -0.619
ENSG00000149115 E027 0.5848540 0.0453875788 3.357058e-01 4.795056e-01 11 57321951 57322197 247 - 0.000 0.212 10.208
ENSG00000149115 E028 0.5117019 0.0274373579 3.342253e-01 4.779725e-01 11 57322237 57322335 99 - 0.000 0.211 10.410
ENSG00000149115 E029 38.8406997 0.0161934238 1.117723e-02 3.159164e-02 11 57324840 57324952 113 - 1.675 1.471 -0.695