ENSG00000148950

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000526776 ENSG00000148950 HEK293_OSMI2_2hA HEK293_TMG_2hB IMMP1L protein_coding protein_coding 70.16163 103.379 39.45855 1.540923 2.492606 -1.389306 9.492727 15.058372 2.991759 1.373844 0.7042482 -2.3276433 0.1263583 0.1453667 0.07553333 -0.06983333 6.733043e-02 5.506117e-11   FALSE
ENST00000532287 ENSG00000148950 HEK293_OSMI2_2hA HEK293_TMG_2hB IMMP1L protein_coding protein_coding 70.16163 103.379 39.45855 1.540923 2.492606 -1.389306 7.927177 7.931209 7.320426 1.698375 0.6354893 -0.1154617 0.1320208 0.0768000 0.18786667 0.11106667 2.158563e-02 5.506117e-11 FALSE TRUE
ENST00000533642 ENSG00000148950 HEK293_OSMI2_2hA HEK293_TMG_2hB IMMP1L protein_coding protein_coding 70.16163 103.379 39.45855 1.540923 2.492606 -1.389306 42.349263 69.582930 17.367411 1.043988 2.1804174 -2.0017276 0.5665792 0.6734000 0.43790000 -0.23550000 9.155656e-05 5.506117e-11   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000148950 E001 2.382179 0.0072200973 3.364108e-01 4.802605e-01 11 31432401 31432401 1 - 0.384 0.539 0.788
ENSG00000148950 E002 56.346446 0.0063035881 9.847638e-05 5.147634e-04 11 31432402 31432430 29 - 1.534 1.763 0.779
ENSG00000148950 E003 105.038690 0.0005271919 1.939270e-13 5.294550e-12 11 31432431 31432492 62 - 1.763 2.042 0.940
ENSG00000148950 E004 221.732417 0.0004977139 6.387036e-28 8.976297e-26 11 31432493 31432568 76 - 2.079 2.367 0.961
ENSG00000148950 E005 343.883543 0.0002916965 8.761472e-40 2.985314e-37 11 31433460 31433570 111 - 2.294 2.553 0.862
ENSG00000148950 E006 3.253468 0.0062575228 2.808470e-01 4.207208e-01 11 31433571 31433755 185 - 0.722 0.538 -0.798
ENSG00000148950 E007 1.073845 0.0120496441 4.504597e-03 1.455564e-02 11 31437076 31437154 79 - 0.585 0.088 -3.672
ENSG00000148950 E008 18.559465 0.0096692093 8.385251e-29 1.272885e-26 11 31447983 31448828 846 - 1.726 0.614 -4.066
ENSG00000148950 E009 16.782066 0.0011294072 3.147174e-14 9.624891e-13 11 31448829 31449029 201 - 1.563 0.922 -2.272
ENSG00000148950 E010 13.531615 0.0014059613 8.035278e-11 1.440851e-09 11 31449030 31449091 62 - 1.462 0.860 -2.163
ENSG00000148950 E011 6.984558 0.0192495592 2.481095e-12 5.707784e-11 11 31452198 31452544 347 - 1.311 0.326 -4.121
ENSG00000148950 E012 5.842984 0.0096585402 7.670056e-10 1.161991e-08 11 31452545 31452717 173 - 1.209 0.369 -3.501
ENSG00000148950 E013 22.962553 0.0230196674 2.367615e-10 3.914281e-09 11 31452718 31453092 375 - 1.697 1.019 -2.368
ENSG00000148950 E014 51.981010 0.0021489648 8.398436e-04 3.401151e-03 11 31456260 31456292 33 - 1.819 1.622 -0.668
ENSG00000148950 E015 50.891602 0.0010187242 2.656355e-04 1.239778e-03 11 31456293 31456312 20 - 1.816 1.609 -0.701
ENSG00000148950 E016 70.186202 0.0003752729 1.122860e-10 1.965528e-09 11 31456313 31456386 74 - 2.001 1.709 -0.981
ENSG00000148950 E017 68.810404 0.0062744381 1.892317e-10 3.183781e-09 11 31460626 31460714 89 - 2.036 1.663 -1.256
ENSG00000148950 E018 136.624067 0.0043417926 1.733455e-05 1.090515e-04 11 31463172 31463305 134 - 2.232 2.032 -0.671
ENSG00000148950 E019 24.664976 0.0087005264 2.559028e-03 8.939046e-03 11 31469740 31469757 18 - 1.546 1.278 -0.924
ENSG00000148950 E020 31.798510 0.0094495669 1.506990e-03 5.658738e-03 11 31469758 31469797 40 - 1.649 1.388 -0.896
ENSG00000148950 E021 20.253898 0.0038766319 9.480839e-06 6.336625e-05 11 31473724 31473786 63 - 1.522 1.150 -1.295
ENSG00000148950 E022 2.248729 0.0063920257 2.223475e-05 1.363956e-04 11 31477115 31477500 386 - 0.855 0.160 -3.787
ENSG00000148950 E023 3.835395 0.0044955141 2.236008e-06 1.721272e-05 11 31477501 31477759 259 - 1.021 0.326 -3.087
ENSG00000148950 E024 14.006880 0.0663653395 6.423936e-01 7.551801e-01 11 31488128 31488196 69 - 1.220 1.094 -0.452
ENSG00000148950 E025 14.403302 0.0230049223 2.452433e-02 6.089920e-02 11 31488197 31488241 45 - 1.320 1.038 -1.004
ENSG00000148950 E026 1.140553 0.0113009763 2.009917e-01 3.274113e-01 11 31509453 31509518 66 - 0.462 0.223 -1.501
ENSG00000148950 E027 255.708463 0.0002909861 5.272794e-08 5.656691e-07 11 31509519 31509645 127 - 2.288 2.393 0.350