ENSG00000148925

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000278174 ENSG00000148925 HEK293_OSMI2_2hA HEK293_TMG_2hB BTBD10 protein_coding protein_coding 9.940121 5.305183 14.74537 0.6455832 0.5597932 1.473049 6.929619 4.6927632 9.438192 0.5449677 0.1053410 1.006530 0.7230958 0.8855667 0.6421333 -0.2434333 6.980135e-07 6.980135e-07 FALSE TRUE
ENST00000528120 ENSG00000148925 HEK293_OSMI2_2hA HEK293_TMG_2hB BTBD10 protein_coding protein_coding 9.940121 5.305183 14.74537 0.6455832 0.5597932 1.473049 2.509007 0.5694522 4.130525 0.1112728 0.7789077 2.837052 0.2216250 0.1061667 0.2772000 0.1710333 8.858886e-03 6.980135e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000148925 E001 0.7406253 0.0153978616 1.193124e-01 2.189572e-01 11 13384518 13384656 139 - 0.312 0.000 -11.335
ENSG00000148925 E002 1.8067887 0.0079365768 5.100306e-04 2.197193e-03 11 13388008 13388023 16 - 0.153 0.742 3.427
ENSG00000148925 E003 172.5760236 0.0030658465 3.539399e-14 1.073361e-12 11 13388024 13388681 658 - 2.104 2.383 0.934
ENSG00000148925 E004 34.8465427 0.0006713508 4.377866e-04 1.919802e-03 11 13388682 13388682 1 - 1.443 1.670 0.778
ENSG00000148925 E005 43.5445213 0.0006833475 2.122529e-05 1.308135e-04 11 13388683 13388701 19 - 1.532 1.777 0.834
ENSG00000148925 E006 129.1797327 0.0003442278 8.440667e-08 8.692428e-07 11 13388702 13389141 440 - 2.025 2.209 0.616
ENSG00000148925 E007 50.0136059 0.0112688585 1.665625e-02 4.418382e-02 11 13403168 13403278 111 - 1.610 1.791 0.615
ENSG00000148925 E008 0.5964967 0.0203146318 8.317673e-01 8.945759e-01 11 13405328 13405548 221 - 0.212 0.177 -0.328
ENSG00000148925 E009 0.9620705 0.0129875033 4.500773e-01 5.912477e-01 11 13405549 13405658 110 - 0.312 0.177 -1.062
ENSG00000148925 E010 61.4716688 0.0117192251 4.056131e-01 5.492966e-01 11 13405659 13405765 107 - 1.746 1.812 0.223
ENSG00000148925 E011 51.9061606 0.0065454945 5.828792e-01 7.071179e-01 11 13405766 13405856 91 - 1.705 1.681 -0.080
ENSG00000148925 E012 59.6224534 0.0004971814 2.048085e-02 5.250388e-02 11 13413530 13413650 121 - 1.788 1.693 -0.321
ENSG00000148925 E013 60.3090733 0.0004136759 2.424867e-05 1.475664e-04 11 13417158 13417246 89 - 1.820 1.626 -0.655
ENSG00000148925 E014 34.1233062 0.0006386795 3.232162e-04 1.473738e-03 11 13417247 13417260 14 - 1.587 1.364 -0.766
ENSG00000148925 E015 42.2937977 0.0005489397 6.628012e-06 4.589390e-05 11 13419460 13419492 33 - 1.684 1.426 -0.882
ENSG00000148925 E016 108.0334052 0.0003132962 1.910968e-06 1.492895e-05 11 13419493 13419745 253 - 2.060 1.903 -0.526
ENSG00000148925 E017 64.1362204 0.0004006413 3.121712e-03 1.062412e-02 11 13421642 13421741 100 - 1.828 1.706 -0.411
ENSG00000148925 E018 29.0359996 0.0006919165 1.541680e-01 2.673355e-01 11 13421742 13421746 5 - 1.481 1.401 -0.275
ENSG00000148925 E019 57.5864808 0.0004354303 4.800770e-04 2.083839e-03 11 13421747 13421815 69 - 1.794 1.636 -0.534
ENSG00000148925 E020 40.3817716 0.0005509414 2.203112e-04 1.050788e-03 11 13421816 13421838 23 - 1.657 1.450 -0.708
ENSG00000148925 E021 0.0000000       11 13439884 13440098 215 -      
ENSG00000148925 E022 0.0000000       11 13440099 13440279 181 -      
ENSG00000148925 E023 36.4572232 0.0006152692 2.171971e-03 7.756039e-03 11 13445024 13445164 141 - 1.603 1.426 -0.608
ENSG00000148925 E024 16.3430400 0.0017360887 3.343604e-01 4.781008e-01 11 13445165 13445181 17 - 1.246 1.178 -0.239
ENSG00000148925 E025 1.0329452 0.0117529599 9.104817e-01 9.470704e-01 11 13459666 13459736 71 - 0.312 0.302 -0.065
ENSG00000148925 E026 0.8900644 0.0575468937 8.755463e-02 1.714273e-01 11 13462622 13462797 176 - 0.355 0.000 -11.597
ENSG00000148925 E027 33.3852774 0.0013906144 2.748731e-01 4.140999e-01 11 13463092 13463099 8 - 1.537 1.486 -0.174
ENSG00000148925 E028 47.5496979 0.0006194509 3.991120e-02 9.087046e-02 11 13463100 13463297 198 - 1.697 1.605 -0.315