ENSG00000148843

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369797 ENSG00000148843 HEK293_OSMI2_2hA HEK293_TMG_2hB PDCD11 protein_coding protein_coding 80.92565 98.21285 56.94004 4.420178 0.8734388 -0.7863619 49.502456 45.681301 41.5973989 7.442661 0.6719567 -0.1350794 0.63317500 0.4649000 0.73096667 0.26606667 7.676946e-03 2.841122e-70 FALSE TRUE
ENST00000478543 ENSG00000148843 HEK293_OSMI2_2hA HEK293_TMG_2hB PDCD11 protein_coding retained_intron 80.92565 98.21285 56.94004 4.420178 0.8734388 -0.7863619 7.103449 15.016654 1.9269168 3.954755 0.2835015 -2.9556899 0.07867917 0.1530333 0.03373333 -0.11930000 1.335260e-03 2.841122e-70 FALSE TRUE
ENST00000649849 ENSG00000148843 HEK293_OSMI2_2hA HEK293_TMG_2hB PDCD11 protein_coding protein_coding 80.92565 98.21285 56.94004 4.420178 0.8734388 -0.7863619 4.857700 0.000000 8.1945466 0.000000 0.9872921 9.6802798 0.07651250 0.0000000 0.14353333 0.14353333 3.595873e-50 2.841122e-70 FALSE TRUE
MSTRG.4586.11 ENSG00000148843 HEK293_OSMI2_2hA HEK293_TMG_2hB PDCD11 protein_coding   80.92565 98.21285 56.94004 4.420178 0.8734388 -0.7863619 4.269367 8.681986 0.8119237 1.462738 0.2851623 -3.4026095 0.04580833 0.0887000 0.01433333 -0.07436667 1.294423e-04 2.841122e-70 FALSE TRUE
MSTRG.4586.15 ENSG00000148843 HEK293_OSMI2_2hA HEK293_TMG_2hB PDCD11 protein_coding   80.92565 98.21285 56.94004 4.420178 0.8734388 -0.7863619 11.640730 27.051483 0.0000000 2.360447 0.0000000 -11.4020252 0.11794167 0.2753000 0.00000000 -0.27530000 2.841122e-70 2.841122e-70 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000148843 E001 0.5975289 0.0246289384 1.612663e-02 4.301442e-02 10 103396622 103396625 4 + 0.404 0.000 -11.032
ENSG00000148843 E002 1.5865792 0.0819168589 9.815570e-02 1.877170e-01 10 103396626 103396634 9 + 0.567 0.262 -1.697
ENSG00000148843 E003 11.7304447 0.0120493247 9.003378e-03 2.628829e-02 10 103396635 103396649 15 + 1.244 0.979 -0.955
ENSG00000148843 E004 25.5927052 0.0007730816 5.726669e-06 4.022022e-05 10 103396650 103396660 11 + 1.574 1.277 -1.026
ENSG00000148843 E005 167.3232639 0.0096269739 1.249631e-08 1.513820e-07 10 103396661 103396730 70 + 2.374 2.074 -1.004
ENSG00000148843 E006 250.7040631 0.0064557779 1.893009e-11 3.767068e-10 10 103398416 103398528 113 + 2.545 2.254 -0.970
ENSG00000148843 E007 1.9532977 0.1112701839 1.634363e-01 2.796267e-01 10 103399647 103399733 87 + 0.610 0.325 -1.463
ENSG00000148843 E008 10.1621406 0.0042774508 4.199917e-04 1.850978e-03 10 103399734 103399830 97 + 1.224 0.866 -1.313
ENSG00000148843 E009 314.6260901 0.0067382700 3.056712e-08 3.434871e-07 10 103400397 103400528 132 + 2.616 2.383 -0.778
ENSG00000148843 E010 319.9661151 0.0056361633 3.041519e-08 3.420030e-07 10 103403118 103403226 109 + 2.615 2.399 -0.721
ENSG00000148843 E011 277.3034832 0.0111357775 4.016508e-05 2.314219e-04 10 103403227 103403285 59 + 2.550 2.340 -0.700
ENSG00000148843 E012 432.5483071 0.0048966396 1.484373e-10 2.544427e-09 10 103405022 103405183 162 + 2.753 2.523 -0.764
ENSG00000148843 E013 1.8434116 0.0074617692 2.378245e-01 3.716286e-01 10 103405184 103405372 189 + 0.567 0.376 -0.965
ENSG00000148843 E014 389.0272355 0.0051064066 3.732063e-13 9.789923e-12 10 103405985 103406108 124 + 2.727 2.455 -0.903
ENSG00000148843 E015 472.1441376 0.0024670122 3.491013e-18 1.797179e-16 10 103406609 103406781 173 + 2.796 2.554 -0.803
ENSG00000148843 E016 186.2893426 0.0002303915 1.709179e-13 4.706378e-12 10 103406782 103406790 9 + 2.364 2.178 -0.619
ENSG00000148843 E017 344.8197320 0.0025342984 2.736422e-09 3.744903e-08 10 103409699 103409806 108 + 2.624 2.450 -0.579
ENSG00000148843 E018 455.3560933 0.0047212916 6.700007e-06 4.634498e-05 10 103413116 103413322 207 + 2.736 2.580 -0.520
ENSG00000148843 E019 183.4610327 0.0044062640 1.361397e-04 6.863759e-04 10 103413966 103413970 5 + 2.338 2.189 -0.495
ENSG00000148843 E020 375.1316152 0.0040539440 5.895048e-07 5.144406e-06 10 103413971 103414090 120 + 2.658 2.490 -0.558
ENSG00000148843 E021 310.9588579 0.0021011684 4.140331e-10 6.584179e-09 10 103414270 103414330 61 + 2.581 2.405 -0.587
ENSG00000148843 E022 420.8174422 0.0015620190 5.227489e-12 1.139436e-10 10 103415005 103415151 147 + 2.708 2.541 -0.556
ENSG00000148843 E023 566.1691105 0.0020854577 7.071286e-07 6.065534e-06 10 103416491 103416742 252 + 2.811 2.690 -0.400
ENSG00000148843 E024 448.1304292 0.0027587557 1.901973e-03 6.920843e-03 10 103417792 103417932 141 + 2.688 2.605 -0.274
ENSG00000148843 E025 563.1329883 0.0006834809 1.897407e-06 1.483770e-05 10 103418440 103418634 195 + 2.786 2.704 -0.274
ENSG00000148843 E026 506.0753859 0.0017461095 1.095070e-06 9.013487e-06 10 103419538 103419708 171 + 2.759 2.643 -0.388
ENSG00000148843 E027 556.4982022 0.0014568131 2.272730e-05 1.390659e-04 10 103421348 103421567 220 + 2.787 2.695 -0.305
ENSG00000148843 E028 4.1340897 0.0051154321 4.353546e-01 5.775976e-01 10 103422725 103422987 263 + 0.610 0.734 0.523
ENSG00000148843 E029 424.3923883 0.0029636022 2.914281e-02 7.027593e-02 10 103422988 103423137 150 + 2.651 2.590 -0.200
ENSG00000148843 E030 384.6954061 0.0018067366 5.234694e-04 2.247574e-03 10 103423543 103423658 116 + 2.623 2.538 -0.282
ENSG00000148843 E031 1194.3383298 0.0007513957 2.051239e-04 9.859468e-04 10 103424984 103425525 542 + 3.094 3.044 -0.166
ENSG00000148843 E032 390.3594571 0.0004681040 8.091528e-02 1.609659e-01 10 103427329 103427391 63 + 2.595 2.570 -0.085
ENSG00000148843 E033 462.4870065 0.0001746448 6.917619e-01 7.931790e-01 10 103432129 103432234 106 + 2.640 2.657 0.058
ENSG00000148843 E034 321.3784876 0.0003004747 7.529563e-02 1.519977e-01 10 103433948 103433992 45 + 2.464 2.513 0.164
ENSG00000148843 E035 284.0343551 0.0013537763 1.780979e-03 6.539034e-03 10 103433993 103434037 45 + 2.377 2.476 0.331
ENSG00000148843 E036 428.2407851 0.0004626655 1.550495e-02 4.164057e-02 10 103434248 103434350 103 + 2.580 2.639 0.199
ENSG00000148843 E037 13.2632856 0.0023256845 2.161996e-03 7.726683e-03 10 103434351 103434702 352 + 1.297 1.027 -0.965
ENSG00000148843 E038 413.3357626 0.0002371802 1.174754e-02 3.293140e-02 10 103434798 103434896 99 + 2.565 2.624 0.196
ENSG00000148843 E039 425.5328362 0.0012617661 4.857546e-01 6.235753e-01 10 103434897 103434975 79 + 2.600 2.627 0.091
ENSG00000148843 E040 451.5974168 0.0002347070 2.370686e-01 3.707931e-01 10 103438015 103438071 57 + 2.622 2.654 0.108
ENSG00000148843 E041 629.1983144 0.0002719170 5.691865e-02 1.213189e-01 10 103438686 103438808 123 + 2.760 2.801 0.138
ENSG00000148843 E042 632.0904288 0.0002893416 7.147893e-03 2.160792e-02 10 103439746 103439868 123 + 2.752 2.806 0.181
ENSG00000148843 E043 556.3478764 0.0016737544 3.572265e-01 5.016269e-01 10 103440290 103440375 86 + 2.711 2.742 0.105
ENSG00000148843 E044 713.7958548 0.0001289976 2.128353e-06 1.645487e-05 10 103440376 103440581 206 + 2.789 2.869 0.264
ENSG00000148843 E045 512.2649708 0.0019069981 1.783746e-13 4.897755e-12 10 103440734 103440850 117 + 2.554 2.763 0.697
ENSG00000148843 E046 736.8742184 0.0015351156 9.787244e-13 2.407380e-11 10 103441826 103441975 150 + 2.735 2.912 0.589
ENSG00000148843 E047 64.3528644 0.0082037088 3.345464e-02 7.868452e-02 10 103442210 103442212 3 + 1.707 1.854 0.498
ENSG00000148843 E048 1037.0530432 0.0010922769 7.236485e-21 5.144204e-19 10 103442213 103442460 248 + 2.871 3.065 0.642
ENSG00000148843 E049 872.0254938 0.0012101830 1.968592e-21 1.482289e-19 10 103443165 103443333 169 + 2.784 2.993 0.697
ENSG00000148843 E050 729.7248283 0.0014568563 1.130006e-24 1.197964e-22 10 103443915 103444068 154 + 2.677 2.926 0.828
ENSG00000148843 E051 33.1691595 0.0039091568 2.353924e-02 5.886114e-02 10 103444313 103444516 204 + 1.408 1.576 0.576
ENSG00000148843 E052 899.2299050 0.0039627404 9.182486e-11 1.630972e-09 10 103444517 103444682 166 + 2.788 3.011 0.743
ENSG00000148843 E053 2154.6028265 0.0068211255 9.642545e-11 1.705650e-09 10 103445378 103446294 917 + 3.139 3.399 0.865