ENSG00000148814

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000344079 ENSG00000148814 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC27 protein_coding protein_coding 5.119897 5.20903 4.070716 0.4416802 0.2784469 -0.3549594 0.7543367 1.1756306 0.1727706 0.10493980 0.09112015 -2.69754899 0.1410958 0.22940000 0.04336667 -0.18603333 0.04476917 0.04476917 FALSE TRUE
ENST00000450442 ENSG00000148814 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC27 protein_coding processed_transcript 5.119897 5.20903 4.070716 0.4416802 0.2784469 -0.3549594 0.5690316 0.0000000 0.5312982 0.00000000 0.42859359 5.75835180 0.1044917 0.00000000 0.11956667 0.11956667 0.21677455 0.04476917 FALSE FALSE
ENST00000472387 ENSG00000148814 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC27 protein_coding processed_transcript 5.119897 5.20903 4.070716 0.4416802 0.2784469 -0.3549594 0.1402912 0.0000000 0.4032499 0.00000000 0.40324986 5.36894244 0.0295875 0.00000000 0.10176667 0.10176667 0.81054399 0.04476917 FALSE FALSE
ENST00000472556 ENSG00000148814 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC27 protein_coding processed_transcript 5.119897 5.20903 4.070716 0.4416802 0.2784469 -0.3549594 1.5360702 1.8957055 0.9818135 0.27616653 0.27222944 -0.94218447 0.2966292 0.36190000 0.24380000 -0.11810000 0.49882305 0.04476917 FALSE TRUE
ENST00000489204 ENSG00000148814 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC27 protein_coding processed_transcript 5.119897 5.20903 4.070716 0.4416802 0.2784469 -0.3549594 0.2557667 0.2166626 0.2209695 0.08390769 0.06356074 0.02715602 0.0524875 0.03956667 0.05283333 0.01326667 0.80024135 0.04476917   FALSE
ENST00000625755 ENSG00000148814 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC27 protein_coding protein_coding 5.119897 5.20903 4.070716 0.4416802 0.2784469 -0.3549594 1.1432744 1.3123256 1.0760564 0.15162760 0.13349651 -0.28397835 0.2331500 0.25486667 0.26850000 0.01363333 0.96898631 0.04476917 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000148814 E001 3.7871403 0.0043239806 0.9391123849 0.965765366 10 132332128 132332151 24 + 0.654 0.642 -0.048
ENSG00000148814 E002 3.9343894 0.0040765109 0.7258514197 0.819028952 10 132332152 132332153 2 + 0.694 0.642 -0.218
ENSG00000148814 E003 3.9343894 0.0040765109 0.7258514197 0.819028952 10 132332154 132332154 1 + 0.694 0.642 -0.218
ENSG00000148814 E004 10.7213608 0.0064283949 0.2609758590 0.398570640 10 132332155 132332192 38 + 1.108 0.988 -0.438
ENSG00000148814 E005 14.6673043 0.0013768301 0.1793015083 0.300236285 10 132332193 132332225 33 + 1.236 1.117 -0.422
ENSG00000148814 E006 18.0052115 0.0011192971 0.1629993961 0.279053187 10 132332226 132332256 31 + 1.316 1.204 -0.394
ENSG00000148814 E007 8.6214526 0.0233776295 0.0186037038 0.048461566 10 132332279 132332536 258 + 0.694 1.030 1.304
ENSG00000148814 E008 41.1382746 0.0006175801 0.9596905738 0.978686010 10 132333477 132333734 258 + 1.587 1.591 0.012
ENSG00000148814 E009 0.2214452 0.0400252372 0.8396265896   10 132335108 132335241 134 + 0.000 0.094 9.109
ENSG00000148814 E010 0.0000000       10 132336764 132336793 30 +      
ENSG00000148814 E011 0.5169874 0.0217681645 0.9616658679 0.979855280 10 132336794 132336828 35 + 0.158 0.171 0.143
ENSG00000148814 E012 0.3634088 0.3356464598 0.5057123355   10 132337138 132337421 284 + 0.000 0.172 9.756
ENSG00000148814 E013 18.4834982 0.0013824689 0.9064732584 0.944578741 10 132337565 132337665 101 + 1.257 1.248 -0.033
ENSG00000148814 E014 12.7659629 0.0023993301 0.4180999458 0.561391010 10 132337666 132337695 30 + 1.044 1.125 0.293
ENSG00000148814 E015 13.2285640 0.0059602444 0.9713953769 0.986131628 10 132342213 132342271 59 + 1.122 1.118 -0.018
ENSG00000148814 E016 23.8996803 0.0116026294 0.5713530501 0.697650168 10 132344498 132344650 153 + 1.399 1.348 -0.176
ENSG00000148814 E017 1.5404930 0.0107090021 0.8905869030 0.934125896 10 132344651 132344867 217 + 0.364 0.389 0.144
ENSG00000148814 E018 30.3190782 0.0026394639 0.5446272547 0.675071968 10 132347984 132348191 208 + 1.494 1.455 -0.134
ENSG00000148814 E019 35.0566060 0.0007004112 0.8169832535 0.884227792 10 132348192 132348356 165 + 1.518 1.533 0.051
ENSG00000148814 E020 11.7439489 0.0253576698 0.8441883584 0.902991376 10 132348963 132349057 95 + 1.061 1.089 0.099
ENSG00000148814 E021 10.0657359 0.0633260828 0.3540423777 0.498319177 10 132350400 132351606 1207 + 1.109 0.963 -0.534
ENSG00000148814 E022 28.4563322 0.0040216133 0.1087652577 0.203715896 10 132351607 132351753 147 + 1.360 1.479 0.412
ENSG00000148814 E023 1.3253775 0.0099248277 0.9078950688 0.945542835 10 132352882 132352905 24 + 0.364 0.344 -0.120
ENSG00000148814 E024 6.9942416 0.0027363721 0.0007554824 0.003099194 10 132352906 132353396 491 + 0.504 0.987 1.990
ENSG00000148814 E025 16.0323315 0.0208847119 0.5673014607 0.694130153 10 132355790 132355886 97 + 1.163 1.226 0.222
ENSG00000148814 E026 18.5316847 0.0026322751 0.4659127702 0.605502966 10 132361457 132361575 119 + 1.224 1.287 0.219
ENSG00000148814 E027 0.0000000       10 132361576 132361589 14 +      
ENSG00000148814 E028 15.3442608 0.0024587113 0.2817631345 0.421676467 10 132365424 132365470 47 + 1.123 1.222 0.356
ENSG00000148814 E029 10.2570364 0.0021692511 0.2069579766 0.334895603 10 132365471 132365480 10 + 0.927 1.066 0.514
ENSG00000148814 E030 14.0534666 0.0201579537 0.4763841572 0.615005175 10 132365481 132365550 70 + 1.093 1.180 0.313
ENSG00000148814 E031 0.9911135 0.0132262396 0.4749554554 0.613733715 10 132366299 132366434 136 + 0.364 0.237 -0.856
ENSG00000148814 E032 2.9109855 0.0324606723 0.1841098592 0.306382115 10 132366435 132366614 180 + 0.694 0.470 -1.015
ENSG00000148814 E033 1.7391111 0.0844177487 0.4214989883 0.564646326 10 132366615 132366677 63 + 0.504 0.347 -0.840
ENSG00000148814 E034 1.7089221 0.2550260310 0.2602081235 0.397683458 10 132366678 132366843 166 + 0.561 0.301 -1.402
ENSG00000148814 E035 4.5789573 0.0042382897 0.8709926503 0.921049532 10 132366846 132367001 156 + 0.731 0.709 -0.091
ENSG00000148814 E036 24.5080028 0.0017756493 0.0102710291 0.029433891 10 132375066 132381508 6443 + 1.494 1.318 -0.610