ENSG00000148773

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368653 ENSG00000148773 HEK293_OSMI2_2hA HEK293_TMG_2hB MKI67 protein_coding protein_coding 55.91277 57.51881 44.59982 5.909118 2.635357 -0.3669233 22.704518 24.537538 15.528783 2.622450 1.4711167 -0.6597048 0.4039750 0.42680000 0.3467333 -0.08006667 3.185864e-02 1.612293e-33 FALSE TRUE
ENST00000368654 ENSG00000148773 HEK293_OSMI2_2hA HEK293_TMG_2hB MKI67 protein_coding protein_coding 55.91277 57.51881 44.59982 5.909118 2.635357 -0.3669233 8.358052 4.239322 12.577623 2.483904 0.4730057 1.5667012 0.1601833 0.06646667 0.2836000 0.21713333 3.777783e-01 1.612293e-33 FALSE TRUE
ENST00000464771 ENSG00000148773 HEK293_OSMI2_2hA HEK293_TMG_2hB MKI67 protein_coding processed_transcript 55.91277 57.51881 44.59982 5.909118 2.635357 -0.3669233 14.695497 17.686461 6.604724 2.490781 1.0727276 -1.4197080 0.2401083 0.30520000 0.1463000 -0.15890000 2.293686e-04 1.612293e-33 FALSE TRUE
MSTRG.4810.5 ENSG00000148773 HEK293_OSMI2_2hA HEK293_TMG_2hB MKI67 protein_coding   55.91277 57.51881 44.59982 5.909118 2.635357 -0.3669233 3.677014 9.729944 0.000000 1.483362 0.0000000 -9.9277697 0.0605625 0.17533333 0.0000000 -0.17533333 1.312647e-21 1.612293e-33 FALSE TRUE
MSTRG.4810.6 ENSG00000148773 HEK293_OSMI2_2hA HEK293_TMG_2hB MKI67 protein_coding   55.91277 57.51881 44.59982 5.909118 2.635357 -0.3669233 4.006497 0.000000 6.897716 0.000000 0.6831484 9.4320650 0.0861750 0.00000000 0.1568000 0.15680000 1.612293e-33 1.612293e-33 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000148773 E001 594.8782928 0.0124574842 9.033804e-13 2.234531e-11 10 128096659 128097366 708 - 2.510 2.872 1.205
ENSG00000148773 E002 444.9900346 0.0045994367 2.352255e-12 5.432495e-11 10 128097367 128097909 543 - 2.493 2.711 0.727
ENSG00000148773 E003 1377.7932636 0.0052455716 8.832085e-19 4.915429e-17 10 128097910 128098730 821 - 2.947 3.214 0.888
ENSG00000148773 E004 435.8578932 0.0015358964 1.163848e-30 2.054870e-28 10 128098731 128098784 54 - 2.453 2.712 0.862
ENSG00000148773 E005 416.9798961 0.0023528334 2.496060e-26 3.058675e-24 10 128098785 128098820 36 - 2.422 2.698 0.920
ENSG00000148773 E006 267.1159426 0.0009642171 4.769197e-30 8.067053e-28 10 128098821 128098822 2 - 2.233 2.503 0.902
ENSG00000148773 E007 346.3682759 0.0018678239 1.746379e-27 2.371658e-25 10 128098823 128098852 30 - 2.342 2.618 0.918
ENSG00000148773 E008 319.5567091 0.0019315749 3.450784e-24 3.490340e-22 10 128098853 128098866 14 - 2.317 2.580 0.875
ENSG00000148773 E009 1109.5613569 0.0045532344 6.068710e-23 5.349925e-21 10 128098867 128099255 389 - 2.835 3.126 0.967
ENSG00000148773 E010 958.9884114 0.0063528817 3.902699e-17 1.762887e-15 10 128101258 128101483 226 - 2.770 3.063 0.975
ENSG00000148773 E011 623.1754867 0.0072020074 3.808504e-13 9.976627e-12 10 128101484 128101625 142 - 2.596 2.872 0.916
ENSG00000148773 E012 395.8312244 0.0044552790 1.018645e-12 2.498437e-11 10 128101626 128101701 76 - 2.436 2.661 0.748
ENSG00000148773 E013 2639.0455643 0.0003554452 3.191728e-30 5.481989e-28 10 128102579 128104131 1553 - 3.363 3.437 0.247
ENSG00000148773 E014 254.8669116 0.0001784612 7.036752e-01 8.023586e-01 10 128104132 128104183 52 - 2.416 2.379 -0.123
ENSG00000148773 E015 611.2318453 0.0040359502 6.963518e-01 7.967300e-01 10 128104184 128104497 314 - 2.807 2.752 -0.182
ENSG00000148773 E016 244.0537673 0.0035028005 5.949701e-01 7.171234e-01 10 128104498 128104549 52 - 2.412 2.350 -0.206
ENSG00000148773 E017 1381.8839983 0.0038741785 5.719749e-04 2.428919e-03 10 128104550 128105580 1031 - 3.210 3.069 -0.469
ENSG00000148773 E018 519.5226636 0.0043587066 2.168037e-05 1.333026e-04 10 128105581 128105860 280 - 2.810 2.622 -0.624
ENSG00000148773 E019 262.1010069 0.0035666650 1.794472e-06 1.410319e-05 10 128105861 128105946 86 - 2.526 2.312 -0.714
ENSG00000148773 E020 307.4895522 0.0020517390 2.021538e-12 4.717013e-11 10 128105947 128106105 159 - 2.613 2.360 -0.841
ENSG00000148773 E021 433.7518728 0.0073922649 5.550837e-08 5.921702e-07 10 128106106 128106471 366 - 2.775 2.496 -0.929
ENSG00000148773 E022 917.6136914 0.0114429623 9.429403e-09 1.168633e-07 10 128106472 128107459 988 - 3.122 2.793 -1.093
ENSG00000148773 E023 467.7093120 0.0183986619 1.492864e-05 9.533424e-05 10 128107460 128107929 470 - 2.826 2.507 -1.060
ENSG00000148773 E024 278.2760518 0.0193455315 8.146272e-05 4.348933e-04 10 128107930 128108188 259 - 2.594 2.290 -1.015
ENSG00000148773 E025 338.8022484 0.0238118180 1.866552e-06 1.461995e-05 10 128108189 128108502 314 - 2.716 2.324 -1.308
ENSG00000148773 E026 684.1673675 0.0300517360 2.555738e-08 2.917607e-07 10 128108503 128109423 921 - 3.055 2.568 -1.619
ENSG00000148773 E027 163.3824961 0.0531411146 8.844200e-05 4.676922e-04 10 128110378 128110533 156 - 2.424 1.968 -1.527
ENSG00000148773 E028 0.2966881 0.0275317970 1.621590e-01   10 128111520 128111644 125 - 0.241 0.000 -10.021
ENSG00000148773 E029 167.2168071 0.0157770614 1.711244e-12 4.034988e-11 10 128111645 128111816 172 - 2.453 1.940 -1.715
ENSG00000148773 E030 153.5328908 0.0103405436 8.221489e-20 5.106677e-18 10 128111927 128112045 119 - 2.435 1.862 -1.916
ENSG00000148773 E031 284.7848597 0.0259897065 1.045254e-12 2.557080e-11 10 128112133 128112445 313 - 2.714 2.102 -2.040
ENSG00000148773 E032 0.0000000       10 128112446 128112449 4 -      
ENSG00000148773 E033 185.3670124 0.0274833373 1.078337e-10 1.893130e-09 10 128113427 128113602 176 - 2.519 1.939 -1.938
ENSG00000148773 E034 238.7986676 0.0197106413 2.625026e-17 1.212048e-15 10 128114928 128115509 582 - 2.649 1.996 -2.181
ENSG00000148773 E035 205.8243437 0.0089561622 2.355277e-34 5.542859e-32 10 128115510 128116007 498 - 2.597 1.891 -2.360
ENSG00000148773 E036 92.1614024 0.0023307876 7.354250e-40 2.528568e-37 10 128116491 128116536 46 - 2.235 1.588 -2.179
ENSG00000148773 E037 84.1365310 0.0058840446 1.345808e-23 1.273523e-21 10 128119253 128119319 67 - 2.184 1.586 -2.015
ENSG00000148773 E038 98.7918222 0.0011096654 5.158263e-45 2.412883e-42 10 128122881 128122996 116 - 2.257 1.642 -2.066
ENSG00000148773 E039 74.7224732 0.0494787012 3.562275e-07 3.244695e-06 10 128123091 128123169 79 - 2.137 1.527 -2.059
ENSG00000148773 E040 84.3652532 0.0759260673 3.819911e-06 2.791939e-05 10 128125576 128125756 181 - 2.198 1.553 -2.176
ENSG00000148773 E041 41.4678515 0.0459175182 7.261638e-09 9.179259e-08 10 128126099 128126154 56 - 1.914 1.189 -2.486
ENSG00000148773 E042 29.4604151 0.0603150050 1.002316e-06 8.313369e-06 10 128126155 128126192 38 - 1.762 1.075 -2.383
ENSG00000148773 E043 39.6514366 0.1032606185 3.575548e-05 2.085327e-04 10 128126193 128126423 231 - 1.885 1.200 -2.349