ENSG00000148737

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000466338 ENSG00000148737 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF7L2 protein_coding protein_coding 10.43676 12.9779 7.871798 0.5147819 0.6691 -0.7205717 0.3806257 0.7613525 0.0000000 0.7613525 0.00000000 -6.2693184 0.03147500 0.05573333 0.00000000 -0.05573333 8.855255e-01 1.570457e-26 FALSE FALSE
ENST00000480888 ENSG00000148737 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF7L2 protein_coding protein_coding 10.43676 12.9779 7.871798 0.5147819 0.6691 -0.7205717 2.8736899 7.3790134 0.0000000 0.7749880 0.00000000 -9.5292379 0.23001250 0.56856667 0.00000000 -0.56856667 1.570457e-26 1.570457e-26   FALSE
ENST00000536810 ENSG00000148737 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF7L2 protein_coding protein_coding 10.43676 12.9779 7.871798 0.5147819 0.6691 -0.7205717 1.0384269 0.4147465 0.9371790 0.1246915 0.12088315 1.1570352 0.10949167 0.03200000 0.11840000 0.08640000 2.344953e-03 1.570457e-26 FALSE TRUE
ENST00000538897 ENSG00000148737 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF7L2 protein_coding protein_coding 10.43676 12.9779 7.871798 0.5147819 0.6691 -0.7205717 0.8669440 0.8474113 1.1022094 0.2622184 0.04648762 0.3753690 0.08937500 0.06713333 0.14286667 0.07573333 1.423934e-01 1.570457e-26 FALSE TRUE
ENST00000545257 ENSG00000148737 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF7L2 protein_coding protein_coding 10.43676 12.9779 7.871798 0.5147819 0.6691 -0.7205717 0.4559888 0.1378809 1.1694321 0.1378809 0.22541240 2.9955843 0.05020417 0.01036667 0.14896667 0.13860000 1.683445e-02 1.570457e-26 FALSE TRUE
ENST00000629706 ENSG00000148737 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF7L2 protein_coding protein_coding 10.43676 12.9779 7.871798 0.5147819 0.6691 -0.7205717 0.9285941 0.8819091 0.3262998 0.1449299 0.17514126 -1.4071487 0.08970417 0.06910000 0.03976667 -0.02933333 6.492413e-01 1.570457e-26 FALSE TRUE
ENST00000636309 ENSG00000148737 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF7L2 protein_coding processed_transcript 10.43676 12.9779 7.871798 0.5147819 0.6691 -0.7205717 0.3310436 0.0000000 0.7631242 0.0000000 0.76312416 6.2726282 0.03284167 0.00000000 0.08303333 0.08303333 7.693299e-01 1.570457e-26   FALSE
MSTRG.4657.1 ENSG00000148737 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF7L2 protein_coding   10.43676 12.9779 7.871798 0.5147819 0.6691 -0.7205717 1.2529002 1.5062413 1.9686820 0.1794717 0.20873500 0.3840405 0.12780833 0.11743333 0.25100000 0.13356667 5.086544e-03 1.570457e-26 FALSE TRUE
MSTRG.4657.15 ENSG00000148737 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF7L2 protein_coding   10.43676 12.9779 7.871798 0.5147819 0.6691 -0.7205717 0.6740599 0.0000000 0.5473633 0.0000000 0.31495508 5.8005461 0.07227917 0.00000000 0.07660000 0.07660000 1.575907e-01 1.570457e-26 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000148737 E001 0.5181333 0.0204087854 5.079237e-01 6.433589e-01 10 112946308 112946416 109 + 0.212 0.126 -0.904
ENSG00000148737 E002 0.1515154 0.0427016250 4.434333e-01   10 112950247 112950249 3 + 0.119 0.000 -11.229
ENSG00000148737 E003 10.9578041 0.0038548287 2.870372e-02 6.941248e-02 10 112950250 112950451 202 + 1.144 0.989 -0.561
ENSG00000148737 E004 10.7144847 0.0065372192 2.229498e-01 3.538963e-01 10 112950452 112950585 134 + 1.091 1.032 -0.216
ENSG00000148737 E005 6.6600154 0.0058982225 4.586385e-02 1.017873e-01 10 112950586 112950659 74 + 0.963 0.782 -0.699
ENSG00000148737 E006 3.9296771 0.0084121418 1.515802e-02 4.084579e-02 10 112950660 112950663 4 + 0.824 0.525 -1.269
ENSG00000148737 E007 12.3026768 0.0017352347 1.764652e-02 4.637435e-02 10 112950664 112950756 93 + 1.199 1.045 -0.554
ENSG00000148737 E008 8.8662572 0.0073416548 3.210276e-02 7.605636e-02 10 112950757 112950765 9 + 1.080 0.906 -0.643
ENSG00000148737 E009 25.3576228 0.0315015541 8.887954e-02 1.734031e-01 10 112950766 112950915 150 + 1.480 1.356 -0.429
ENSG00000148737 E010 17.7668908 0.0102172656 7.987876e-03 2.374806e-02 10 112950916 112950945 30 + 1.356 1.180 -0.619
ENSG00000148737 E011 27.1572204 0.0007930395 1.747657e-03 6.432899e-03 10 112951207 112951273 67 + 1.516 1.384 -0.456
ENSG00000148737 E012 46.6669755 0.0008154461 3.144436e-06 2.341604e-05 10 112951483 112951607 125 + 1.754 1.587 -0.566
ENSG00000148737 E013 5.8281560 0.0028237312 3.428559e-02 8.030590e-02 10 112964556 112964624 69 + 0.933 0.730 -0.791
ENSG00000148737 E014 48.5256223 0.0032241719 5.016503e-04 2.165967e-03 10 113040025 113040126 102 + 1.749 1.628 -0.410
ENSG00000148737 E015 1.3359615 0.0762891905 4.357349e-01 5.779263e-01 10 113089397 113089399 3 + 0.411 0.304 -0.635
ENSG00000148737 E016 4.1747505 0.0039682658 7.446241e-01 8.328848e-01 10 113089400 113089540 141 + 0.650 0.756 0.442
ENSG00000148737 E017 0.0000000       10 113125536 113125938 403 +      
ENSG00000148737 E018 0.0000000       10 113126022 113126102 81 +      
ENSG00000148737 E019 0.0000000       10 113126690 113126881 192 +      
ENSG00000148737 E020 0.0000000       10 113126957 113127053 97 +      
ENSG00000148737 E021 0.0000000       10 113129206 113129356 151 +      
ENSG00000148737 E022 0.0000000       10 113129357 113129372 16 +      
ENSG00000148737 E023 0.0000000       10 113129373 113129645 273 +      
ENSG00000148737 E024 0.0000000       10 113129646 113129814 169 +      
ENSG00000148737 E025 0.0000000       10 113129815 113129987 173 +      
ENSG00000148737 E026 0.0000000       10 113132022 113132101 80 +      
ENSG00000148737 E027 0.0000000       10 113132896 113133020 125 +      
ENSG00000148737 E028 0.0000000       10 113133240 113133289 50 +      
ENSG00000148737 E029 58.4186284 0.0050019822 9.819247e-02 1.877765e-01 10 113141184 113141316 133 + 1.778 1.760 -0.061
ENSG00000148737 E030 52.0578038 0.0005087640 4.554219e-04 1.988300e-03 10 113143923 113144013 91 + 1.771 1.676 -0.321
ENSG00000148737 E031 28.4965901 0.0030504418 2.393625e-03 8.440958e-03 10 113144014 113144025 12 + 1.536 1.401 -0.464
ENSG00000148737 E032 44.8906593 0.0006678218 1.389072e-03 5.270804e-03 10 113146011 113146071 61 + 1.711 1.620 -0.310
ENSG00000148737 E033 36.0232875 0.0012743888 1.453976e-03 5.486862e-03 10 113146072 113146097 26 + 1.629 1.517 -0.382
ENSG00000148737 E034 8.5885831 0.0019712468 1.424422e-01 2.513600e-01 10 113150983 113150997 15 + 1.032 0.941 -0.337
ENSG00000148737 E035 53.8735077 0.0035909496 1.527851e-03 5.727195e-03 10 113150998 113151082 85 + 1.791 1.693 -0.331
ENSG00000148737 E036 45.7626934 0.0033275584 9.653058e-05 5.057644e-04 10 113151083 113151123 41 + 1.744 1.594 -0.508
ENSG00000148737 E037 44.9037241 0.0016222545 2.258381e-04 1.074039e-03 10 113151725 113151770 46 + 1.721 1.595 -0.429
ENSG00000148737 E038 41.9947641 0.0059497607 1.022027e-02 2.930882e-02 10 113151771 113151830 60 + 1.678 1.587 -0.308
ENSG00000148737 E039 41.1661854 0.0006067663 4.508329e-03 1.456620e-02 10 113151831 113151884 54 + 1.663 1.583 -0.272
ENSG00000148737 E040 43.1271659 0.0005418142 6.424895e-02 1.337792e-01 10 113152333 113152413 81 + 1.657 1.634 -0.080
ENSG00000148737 E041 30.1134288 0.0007052907 1.461585e-01 2.564584e-01 10 113152414 113152440 27 + 1.499 1.481 -0.063
ENSG00000148737 E042 0.2214452 0.0384356873 5.338754e-01   10 113157773 113158020 248 + 0.000 0.126 10.505
ENSG00000148737 E043 36.3351680 0.0009332051 8.803465e-02 1.721376e-01 10 113158021 113158069 49 + 1.582 1.556 -0.088
ENSG00000148737 E044 13.1513575 0.0020363029 2.590555e-01 3.964176e-01 10 113158667 113158717 51 + 1.163 1.129 -0.122
ENSG00000148737 E045 10.8057098 0.0270331322 1.237146e-01 2.252422e-01 10 113159920 113159992 73 + 1.124 1.006 -0.429
ENSG00000148737 E046 3.6847705 0.1647481756 9.327240e-01 9.616179e-01 10 113160619 113160691 73 + 0.619 0.723 0.439
ENSG00000148737 E047 0.8942170 0.0139390473 5.533250e-03 1.737453e-02 10 113161231 113161578 348 + 0.461 0.000 -14.019
ENSG00000148737 E048 0.5954526 0.0172671820 2.882650e-02 6.965947e-02 10 113161579 113161603 25 + 0.354 0.000 -13.430
ENSG00000148737 E049 66.4655551 0.0044462339 5.119515e-01 6.468777e-01 10 113165555 113165855 301 + 1.802 1.841 0.133
ENSG00000148737 E050 500.5632457 0.0033133274 3.239547e-44 1.423950e-41 10 113165856 113167678 1823 + 2.437 2.846 1.361