ENSG00000148719

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338820 ENSG00000148719 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJB12 protein_coding protein_coding 38.24259 50.70334 30.95849 2.092466 0.4933015 -0.7115644 3.001099 5.032036 1.0760671 0.2984154 0.04725465 -2.21489330 0.07528333 0.09930000 0.03483333 -0.06446667 4.905419e-10 4.905419e-10 FALSE TRUE
ENST00000394903 ENSG00000148719 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJB12 protein_coding protein_coding 38.24259 50.70334 30.95849 2.092466 0.4933015 -0.7115644 2.042528 2.346854 0.5894436 2.3468544 0.58944358 -1.97516675 0.05045417 0.05006667 0.01850000 -0.03156667 1.000000e+00 4.905419e-10 FALSE TRUE
ENST00000444643 ENSG00000148719 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJB12 protein_coding protein_coding 38.24259 50.70334 30.95849 2.092466 0.4933015 -0.7115644 13.752798 20.428131 11.1933491 2.3245239 0.60481831 -0.86733319 0.35657083 0.40046667 0.36236667 -0.03810000 7.420560e-01 4.905419e-10 FALSE TRUE
ENST00000463786 ENSG00000148719 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJB12 protein_coding protein_coding 38.24259 50.70334 30.95849 2.092466 0.4933015 -0.7115644 7.196636 9.403165 5.0577363 0.2447722 0.30680218 -0.89333845 0.18528333 0.18606667 0.16340000 -0.02266667 5.598354e-01 4.905419e-10 FALSE TRUE
MSTRG.4143.4 ENSG00000148719 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJB12 protein_coding   38.24259 50.70334 30.95849 2.092466 0.4933015 -0.7115644 2.128077 2.014078 2.8422767 0.3128795 0.77783558 0.49484876 0.05875417 0.03996667 0.09180000 0.05183333 1.365356e-01 4.905419e-10 FALSE TRUE
MSTRG.4143.7 ENSG00000148719 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJB12 protein_coding   38.24259 50.70334 30.95849 2.092466 0.4933015 -0.7115644 6.947471 7.769407 7.2576409 1.0045527 0.51317887 -0.09817304 0.19042500 0.15216667 0.23423333 0.08206667 6.095682e-02 4.905419e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000148719 E001 5.8946800 0.0027336262 2.114300e-01 3.401767e-01 10 72332830 72332862 33 - 0.678 0.850 0.694
ENSG00000148719 E002 151.6633452 0.0067630133 2.415022e-04 1.139637e-03 10 72332863 72333031 169 - 1.997 2.188 0.639
ENSG00000148719 E003 919.3480314 0.0021171441 1.768844e-04 8.648916e-04 10 72333032 72334080 1049 - 2.858 2.942 0.278
ENSG00000148719 E004 106.3363500 0.0002792504 2.377259e-01 3.715082e-01 10 72334081 72334177 97 - 1.958 1.999 0.137
ENSG00000148719 E005 159.0105311 0.0002066772 1.780845e-01 2.987371e-01 10 72334178 72334330 153 - 2.132 2.169 0.127
ENSG00000148719 E006 212.0116399 0.0001746188 5.435740e-01 6.741546e-01 10 72334331 72334522 192 - 2.297 2.278 -0.065
ENSG00000148719 E007 227.5109826 0.0002298169 6.108129e-01 7.300875e-01 10 72334523 72334617 95 - 2.309 2.318 0.032
ENSG00000148719 E008 321.6576539 0.0002914624 5.151125e-13 1.323566e-11 10 72334618 72335556 939 - 2.340 2.506 0.551
ENSG00000148719 E009 111.0164159 0.0003913473 1.338664e-02 3.681477e-02 10 72335557 72335779 223 - 1.937 2.027 0.303
ENSG00000148719 E010 115.8752240 0.0002772286 2.182815e-01 3.483413e-01 10 72335780 72335785 6 - 1.994 2.035 0.137
ENSG00000148719 E011 165.6065812 0.0008385355 2.903103e-02 7.006970e-02 10 72335786 72335833 48 - 2.129 2.197 0.230
ENSG00000148719 E012 383.0572568 0.0001411186 2.839038e-01 4.240995e-01 10 72335834 72335931 98 - 2.527 2.545 0.059
ENSG00000148719 E013 502.6527802 0.0001137164 8.658460e-01 9.176098e-01 10 72336524 72336696 173 - 2.661 2.655 -0.021
ENSG00000148719 E014 14.2776833 0.0457872436 2.909744e-01 4.317872e-01 10 72336697 72336865 169 - 1.230 1.095 -0.482
ENSG00000148719 E015 363.1603963 0.0002962635 5.993265e-02 1.264950e-01 10 72338202 72338311 110 - 2.544 2.502 -0.142
ENSG00000148719 E016 314.1244407 0.0018543526 6.458408e-02 1.343501e-01 10 72340789 72340868 80 - 2.491 2.435 -0.187
ENSG00000148719 E017 455.1658944 0.0018850953 3.401479e-04 1.540963e-03 10 72340985 72341170 186 - 2.679 2.583 -0.320
ENSG00000148719 E018 392.0009404 0.0014233050 2.088836e-07 1.995279e-06 10 72343366 72343511 146 - 2.639 2.506 -0.443
ENSG00000148719 E019 408.4063586 0.0027559735 2.878394e-04 1.330527e-03 10 72344950 72345127 178 - 2.643 2.532 -0.371
ENSG00000148719 E020 0.6060617 0.9170072813 1.709750e-01 2.894447e-01 10 72350659 72350708 50 - 0.463 0.000 -12.376
ENSG00000148719 E021 7.2774617 0.1073360814 1.815964e-01 3.032455e-01 10 72353342 72354380 1039 - 0.677 0.928 0.992
ENSG00000148719 E022 280.6009378 0.0030757431 3.202136e-02 7.590245e-02 10 72354765 72355310 546 - 2.457 2.381 -0.253